Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism. / Jensen, Benjamin A.H.; Holm, Jacob B.; Larsen, Ida S.; von Burg, Nicole; Derer, Stefanie; Sonne, Si B.; Pærregaard, Simone I.; Damgaard, Mads V.; Indrelid, Stine A.; Rivollier, Aymeric; Agrinier, Anne Laure; Sulek, Karolina; Arnoldussen, Yke J.; Fjære, Even; Marette, André; Angell, Inga L.; Rudi, Knut; Treebak, Jonas T.; Madsen, Lise; Åkesson, Caroline Piercey; Agace, William; Sina, Christian; Kleiveland, Charlotte R.; Kristiansen, Karsten; Lea, Tor E.

In: Nature Communications, Vol. 12, 1093, 2021.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jensen, BAH, Holm, JB, Larsen, IS, von Burg, N, Derer, S, Sonne, SB, Pærregaard, SI, Damgaard, MV, Indrelid, SA, Rivollier, A, Agrinier, AL, Sulek, K, Arnoldussen, YJ, Fjære, E, Marette, A, Angell, IL, Rudi, K, Treebak, JT, Madsen, L, Åkesson, CP, Agace, W, Sina, C, Kleiveland, CR, Kristiansen, K & Lea, TE 2021, 'Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism', Nature Communications, vol. 12, 1093. https://doi.org/10.1038/s41467-021-21408-9

APA

Jensen, B. A. H., Holm, J. B., Larsen, I. S., von Burg, N., Derer, S., Sonne, S. B., Pærregaard, S. I., Damgaard, M. V., Indrelid, S. A., Rivollier, A., Agrinier, A. L., Sulek, K., Arnoldussen, Y. J., Fjære, E., Marette, A., Angell, I. L., Rudi, K., Treebak, J. T., Madsen, L., ... Lea, T. E. (2021). Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism. Nature Communications, 12, [1093]. https://doi.org/10.1038/s41467-021-21408-9

Vancouver

Jensen BAH, Holm JB, Larsen IS, von Burg N, Derer S, Sonne SB et al. Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism. Nature Communications. 2021;12. 1093. https://doi.org/10.1038/s41467-021-21408-9

Author

Jensen, Benjamin A.H. ; Holm, Jacob B. ; Larsen, Ida S. ; von Burg, Nicole ; Derer, Stefanie ; Sonne, Si B. ; Pærregaard, Simone I. ; Damgaard, Mads V. ; Indrelid, Stine A. ; Rivollier, Aymeric ; Agrinier, Anne Laure ; Sulek, Karolina ; Arnoldussen, Yke J. ; Fjære, Even ; Marette, André ; Angell, Inga L. ; Rudi, Knut ; Treebak, Jonas T. ; Madsen, Lise ; Åkesson, Caroline Piercey ; Agace, William ; Sina, Christian ; Kleiveland, Charlotte R. ; Kristiansen, Karsten ; Lea, Tor E. / Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism. In: Nature Communications. 2021 ; Vol. 12.

Bibtex

@article{7fac13e0ebee4ac99cf3f288c57bd90f,
title = "Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism",
abstract = "Interactions between host and gut microbial communities are modulated by diets and play pivotal roles in immunological homeostasis and health. We show that exchanging the protein source in a high fat, high sugar, westernized diet from casein to whole-cell lysates of the non-commensal bacterium Methylococcus capsulatus Bath is sufficient to reverse western diet-induced changes in the gut microbiota to a state resembling that of lean, low fat diet-fed mice, both under mild thermal stress (T22 °C) and at thermoneutrality (T30 °C). Concomitant with microbiota changes, mice fed the Methylococcus-based western diet exhibit improved glucose regulation, reduced body and liver fat, and diminished hepatic immune infiltration. Intake of the Methylococcu-based diet markedly boosts Parabacteroides abundances in a manner depending on adaptive immunity, and upregulates triple positive (Foxp3+RORγt+IL-17+) regulatory T cells in the small and large intestine. Collectively, these data point to the potential for leveraging the use of McB lysates to improve immunometabolic homeostasis.",
author = "Jensen, {Benjamin A.H.} and Holm, {Jacob B.} and Larsen, {Ida S.} and {von Burg}, Nicole and Stefanie Derer and Sonne, {Si B.} and P{\ae}rregaard, {Simone I.} and Damgaard, {Mads V.} and Indrelid, {Stine A.} and Aymeric Rivollier and Agrinier, {Anne Laure} and Karolina Sulek and Arnoldussen, {Yke J.} and Even Fj{\ae}re and Andr{\'e} Marette and Angell, {Inga L.} and Knut Rudi and Treebak, {Jonas T.} and Lise Madsen and {\AA}kesson, {Caroline Piercey} and William Agace and Christian Sina and Kleiveland, {Charlotte R.} and Karsten Kristiansen and Lea, {Tor E.}",
year = "2021",
doi = "10.1038/s41467-021-21408-9",
language = "English",
volume = "12",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism

AU - Jensen, Benjamin A.H.

AU - Holm, Jacob B.

AU - Larsen, Ida S.

AU - von Burg, Nicole

AU - Derer, Stefanie

AU - Sonne, Si B.

AU - Pærregaard, Simone I.

AU - Damgaard, Mads V.

AU - Indrelid, Stine A.

AU - Rivollier, Aymeric

AU - Agrinier, Anne Laure

AU - Sulek, Karolina

AU - Arnoldussen, Yke J.

AU - Fjære, Even

AU - Marette, André

AU - Angell, Inga L.

AU - Rudi, Knut

AU - Treebak, Jonas T.

AU - Madsen, Lise

AU - Åkesson, Caroline Piercey

AU - Agace, William

AU - Sina, Christian

AU - Kleiveland, Charlotte R.

AU - Kristiansen, Karsten

AU - Lea, Tor E.

PY - 2021

Y1 - 2021

N2 - Interactions between host and gut microbial communities are modulated by diets and play pivotal roles in immunological homeostasis and health. We show that exchanging the protein source in a high fat, high sugar, westernized diet from casein to whole-cell lysates of the non-commensal bacterium Methylococcus capsulatus Bath is sufficient to reverse western diet-induced changes in the gut microbiota to a state resembling that of lean, low fat diet-fed mice, both under mild thermal stress (T22 °C) and at thermoneutrality (T30 °C). Concomitant with microbiota changes, mice fed the Methylococcus-based western diet exhibit improved glucose regulation, reduced body and liver fat, and diminished hepatic immune infiltration. Intake of the Methylococcu-based diet markedly boosts Parabacteroides abundances in a manner depending on adaptive immunity, and upregulates triple positive (Foxp3+RORγt+IL-17+) regulatory T cells in the small and large intestine. Collectively, these data point to the potential for leveraging the use of McB lysates to improve immunometabolic homeostasis.

AB - Interactions between host and gut microbial communities are modulated by diets and play pivotal roles in immunological homeostasis and health. We show that exchanging the protein source in a high fat, high sugar, westernized diet from casein to whole-cell lysates of the non-commensal bacterium Methylococcus capsulatus Bath is sufficient to reverse western diet-induced changes in the gut microbiota to a state resembling that of lean, low fat diet-fed mice, both under mild thermal stress (T22 °C) and at thermoneutrality (T30 °C). Concomitant with microbiota changes, mice fed the Methylococcus-based western diet exhibit improved glucose regulation, reduced body and liver fat, and diminished hepatic immune infiltration. Intake of the Methylococcu-based diet markedly boosts Parabacteroides abundances in a manner depending on adaptive immunity, and upregulates triple positive (Foxp3+RORγt+IL-17+) regulatory T cells in the small and large intestine. Collectively, these data point to the potential for leveraging the use of McB lysates to improve immunometabolic homeostasis.

U2 - 10.1038/s41467-021-21408-9

DO - 10.1038/s41467-021-21408-9

M3 - Journal article

C2 - 33597537

AN - SCOPUS:85101092638

VL - 12

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 1093

ER -

ID: 258779081