Lymphocyte transformation induced by nickel sulphate: an in vitro study of subjects with and without a positive nickel patch test

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Lymphocyte transformation induced by nickel sulphate: an in vitro study of subjects with and without a positive nickel patch test. / Svejgaard, E; Morling, N; Svejgaard, A; Veien, N K.

In: Acta Dermato Venereologica, Vol. 58, No. 3, 1978, p. 245-50.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Svejgaard, E, Morling, N, Svejgaard, A & Veien, NK 1978, 'Lymphocyte transformation induced by nickel sulphate: an in vitro study of subjects with and without a positive nickel patch test', Acta Dermato Venereologica, vol. 58, no. 3, pp. 245-50.

APA

Svejgaard, E., Morling, N., Svejgaard, A., & Veien, N. K. (1978). Lymphocyte transformation induced by nickel sulphate: an in vitro study of subjects with and without a positive nickel patch test. Acta Dermato Venereologica, 58(3), 245-50.

Vancouver

Svejgaard E, Morling N, Svejgaard A, Veien NK. Lymphocyte transformation induced by nickel sulphate: an in vitro study of subjects with and without a positive nickel patch test. Acta Dermato Venereologica. 1978;58(3):245-50.

Author

Svejgaard, E ; Morling, N ; Svejgaard, A ; Veien, N K. / Lymphocyte transformation induced by nickel sulphate: an in vitro study of subjects with and without a positive nickel patch test. In: Acta Dermato Venereologica. 1978 ; Vol. 58, No. 3. pp. 245-50.

Bibtex

@article{c8357100328c11df8ed1000ea68e967b,
title = "Lymphocyte transformation induced by nickel sulphate: an in vitro study of subjects with and without a positive nickel patch test",
abstract = "Lymphocytes from 8 patients with contact dermatitis and a positive nickel patch test, 7 patients with contact dermatitis due to other factors and with a negative nickel patch test, and 9 other subjects, 7 of whom suffered from other dermatological disorders, were tested with the lymphocyte transformation test (LTT), using nickel sulphate in various concentrations. All execpt one of the nickel allergics showed a significant response to nickel, whereas the controls showed borderline (3 patients) or no response (12 patients). These observations confirm previous findings indicating that nickel hypersensitivity can be diagnosed in vitro. This may be of importance in cases of acute contact dermatitis where patch testing is undesirable. Some individuals with a negative nickel patch test responded significantly though weakly to nickel in the LTT, indicating that apart from acting as a specific antigen (hapten?) nickel sulphate may also have weak non-specific mitogenic properties.",
author = "E Svejgaard and N Morling and A Svejgaard and Veien, {N K}",
note = "Keywords: Allergens; Dermatitis, Contact; Humans; Lymphocyte Activation; Nickel; Patch Tests; Skin Tests",
year = "1978",
language = "English",
volume = "58",
pages = "245--50",
journal = "Acta Dermato-Venereologica",
issn = "0001-5555",
publisher = "Society for the Publication of Acta Dermato - Venereologica",
number = "3",

}

RIS

TY - JOUR

T1 - Lymphocyte transformation induced by nickel sulphate: an in vitro study of subjects with and without a positive nickel patch test

AU - Svejgaard, E

AU - Morling, N

AU - Svejgaard, A

AU - Veien, N K

N1 - Keywords: Allergens; Dermatitis, Contact; Humans; Lymphocyte Activation; Nickel; Patch Tests; Skin Tests

PY - 1978

Y1 - 1978

N2 - Lymphocytes from 8 patients with contact dermatitis and a positive nickel patch test, 7 patients with contact dermatitis due to other factors and with a negative nickel patch test, and 9 other subjects, 7 of whom suffered from other dermatological disorders, were tested with the lymphocyte transformation test (LTT), using nickel sulphate in various concentrations. All execpt one of the nickel allergics showed a significant response to nickel, whereas the controls showed borderline (3 patients) or no response (12 patients). These observations confirm previous findings indicating that nickel hypersensitivity can be diagnosed in vitro. This may be of importance in cases of acute contact dermatitis where patch testing is undesirable. Some individuals with a negative nickel patch test responded significantly though weakly to nickel in the LTT, indicating that apart from acting as a specific antigen (hapten?) nickel sulphate may also have weak non-specific mitogenic properties.

AB - Lymphocytes from 8 patients with contact dermatitis and a positive nickel patch test, 7 patients with contact dermatitis due to other factors and with a negative nickel patch test, and 9 other subjects, 7 of whom suffered from other dermatological disorders, were tested with the lymphocyte transformation test (LTT), using nickel sulphate in various concentrations. All execpt one of the nickel allergics showed a significant response to nickel, whereas the controls showed borderline (3 patients) or no response (12 patients). These observations confirm previous findings indicating that nickel hypersensitivity can be diagnosed in vitro. This may be of importance in cases of acute contact dermatitis where patch testing is undesirable. Some individuals with a negative nickel patch test responded significantly though weakly to nickel in the LTT, indicating that apart from acting as a specific antigen (hapten?) nickel sulphate may also have weak non-specific mitogenic properties.

M3 - Journal article

C2 - 78640

VL - 58

SP - 245

EP - 250

JO - Acta Dermato-Venereologica

JF - Acta Dermato-Venereologica

SN - 0001-5555

IS - 3

ER -

ID: 18693829