Linear motif atlas for phosphorylation-dependent signaling

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Linear motif atlas for phosphorylation-dependent signaling. / Miller, Martin Lee; Jensen, Lars Juhl; Diella, Francesca; Jørgensen, Claus; Tinti, Michele; Li, Lei; Hsiung, Marilyn; Parker, Sirlester A; Bordeaux, Jennifer; Sicheritz-Ponten, Thomas; Olhovsky, Marina; Pasculescu, Adrian; Alexander, Jes; Knapp, Stefan; Blom, Nikolaj; Bork, Peer; Li, Shawn; Cesareni, Gianni; Pawson, Tony; Turk, Benjamin E; Yaffe, Michael B; Brunak, Søren; Linding, Rune.

In: Science Signaling, Vol. 1, No. 35, 2008, p. ra2.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Miller, ML, Jensen, LJ, Diella, F, Jørgensen, C, Tinti, M, Li, L, Hsiung, M, Parker, SA, Bordeaux, J, Sicheritz-Ponten, T, Olhovsky, M, Pasculescu, A, Alexander, J, Knapp, S, Blom, N, Bork, P, Li, S, Cesareni, G, Pawson, T, Turk, BE, Yaffe, MB, Brunak, S & Linding, R 2008, 'Linear motif atlas for phosphorylation-dependent signaling', Science Signaling, vol. 1, no. 35, pp. ra2. https://doi.org/10.1126/scisignal.1159433

APA

Miller, M. L., Jensen, L. J., Diella, F., Jørgensen, C., Tinti, M., Li, L., Hsiung, M., Parker, S. A., Bordeaux, J., Sicheritz-Ponten, T., Olhovsky, M., Pasculescu, A., Alexander, J., Knapp, S., Blom, N., Bork, P., Li, S., Cesareni, G., Pawson, T., ... Linding, R. (2008). Linear motif atlas for phosphorylation-dependent signaling. Science Signaling, 1(35), ra2. https://doi.org/10.1126/scisignal.1159433

Vancouver

Miller ML, Jensen LJ, Diella F, Jørgensen C, Tinti M, Li L et al. Linear motif atlas for phosphorylation-dependent signaling. Science Signaling. 2008;1(35):ra2. https://doi.org/10.1126/scisignal.1159433

Author

Miller, Martin Lee ; Jensen, Lars Juhl ; Diella, Francesca ; Jørgensen, Claus ; Tinti, Michele ; Li, Lei ; Hsiung, Marilyn ; Parker, Sirlester A ; Bordeaux, Jennifer ; Sicheritz-Ponten, Thomas ; Olhovsky, Marina ; Pasculescu, Adrian ; Alexander, Jes ; Knapp, Stefan ; Blom, Nikolaj ; Bork, Peer ; Li, Shawn ; Cesareni, Gianni ; Pawson, Tony ; Turk, Benjamin E ; Yaffe, Michael B ; Brunak, Søren ; Linding, Rune. / Linear motif atlas for phosphorylation-dependent signaling. In: Science Signaling. 2008 ; Vol. 1, No. 35. pp. ra2.

Bibtex

@article{ba5b028f9d55476395f4f614b43b6628,
title = "Linear motif atlas for phosphorylation-dependent signaling",
abstract = "Systematic and quantitative analysis of protein phosphorylation is revealing dynamic regulatory networks underlying cellular responses to environmental cues. However, matching these sites to the kinases that phosphorylate them and the phosphorylation-dependent binding domains that may subsequently bind to them remains a challenge. NetPhorest is an atlas of consensus sequence motifs that covers 179 kinases and 104 phosphorylation-dependent binding domains [Src homology 2 (SH2), phosphotyrosine binding (PTB), BRCA1 C-terminal (BRCT), WW, and 14-3-3]. The atlas reveals new aspects of signaling systems, including the observation that tyrosine kinases mutated in cancer have lower specificity than their non-oncogenic relatives. The resource is maintained by an automated pipeline, which uses phylogenetic trees to structure the currently available in vivo and in vitro data to derive probabilistic sequence models of linear motifs. The atlas is available as a community resource (http://netphorest.info).",
keywords = "14-3-3 Proteins, Amino Acid Motifs, Animals, BRCA1 Protein, Consensus Sequence, Databases, Protein, Humans, Phosphorylation, Phosphotransferases, Phosphotyrosine, Protein Binding, Signal Transduction, src Homology Domains",
author = "Miller, {Martin Lee} and Jensen, {Lars Juhl} and Francesca Diella and Claus J{\o}rgensen and Michele Tinti and Lei Li and Marilyn Hsiung and Parker, {Sirlester A} and Jennifer Bordeaux and Thomas Sicheritz-Ponten and Marina Olhovsky and Adrian Pasculescu and Jes Alexander and Stefan Knapp and Nikolaj Blom and Peer Bork and Shawn Li and Gianni Cesareni and Tony Pawson and Turk, {Benjamin E} and Yaffe, {Michael B} and S{\o}ren Brunak and Rune Linding",
year = "2008",
doi = "10.1126/scisignal.1159433",
language = "English",
volume = "1",
pages = "ra2",
journal = "Science Signaling",
issn = "1945-0877",
publisher = "American Association for the Advancement of Science",
number = "35",

}

RIS

TY - JOUR

T1 - Linear motif atlas for phosphorylation-dependent signaling

AU - Miller, Martin Lee

AU - Jensen, Lars Juhl

AU - Diella, Francesca

AU - Jørgensen, Claus

AU - Tinti, Michele

AU - Li, Lei

AU - Hsiung, Marilyn

AU - Parker, Sirlester A

AU - Bordeaux, Jennifer

AU - Sicheritz-Ponten, Thomas

AU - Olhovsky, Marina

AU - Pasculescu, Adrian

AU - Alexander, Jes

AU - Knapp, Stefan

AU - Blom, Nikolaj

AU - Bork, Peer

AU - Li, Shawn

AU - Cesareni, Gianni

AU - Pawson, Tony

AU - Turk, Benjamin E

AU - Yaffe, Michael B

AU - Brunak, Søren

AU - Linding, Rune

PY - 2008

Y1 - 2008

N2 - Systematic and quantitative analysis of protein phosphorylation is revealing dynamic regulatory networks underlying cellular responses to environmental cues. However, matching these sites to the kinases that phosphorylate them and the phosphorylation-dependent binding domains that may subsequently bind to them remains a challenge. NetPhorest is an atlas of consensus sequence motifs that covers 179 kinases and 104 phosphorylation-dependent binding domains [Src homology 2 (SH2), phosphotyrosine binding (PTB), BRCA1 C-terminal (BRCT), WW, and 14-3-3]. The atlas reveals new aspects of signaling systems, including the observation that tyrosine kinases mutated in cancer have lower specificity than their non-oncogenic relatives. The resource is maintained by an automated pipeline, which uses phylogenetic trees to structure the currently available in vivo and in vitro data to derive probabilistic sequence models of linear motifs. The atlas is available as a community resource (http://netphorest.info).

AB - Systematic and quantitative analysis of protein phosphorylation is revealing dynamic regulatory networks underlying cellular responses to environmental cues. However, matching these sites to the kinases that phosphorylate them and the phosphorylation-dependent binding domains that may subsequently bind to them remains a challenge. NetPhorest is an atlas of consensus sequence motifs that covers 179 kinases and 104 phosphorylation-dependent binding domains [Src homology 2 (SH2), phosphotyrosine binding (PTB), BRCA1 C-terminal (BRCT), WW, and 14-3-3]. The atlas reveals new aspects of signaling systems, including the observation that tyrosine kinases mutated in cancer have lower specificity than their non-oncogenic relatives. The resource is maintained by an automated pipeline, which uses phylogenetic trees to structure the currently available in vivo and in vitro data to derive probabilistic sequence models of linear motifs. The atlas is available as a community resource (http://netphorest.info).

KW - 14-3-3 Proteins

KW - Amino Acid Motifs

KW - Animals

KW - BRCA1 Protein

KW - Consensus Sequence

KW - Databases, Protein

KW - Humans

KW - Phosphorylation

KW - Phosphotransferases

KW - Phosphotyrosine

KW - Protein Binding

KW - Signal Transduction

KW - src Homology Domains

U2 - 10.1126/scisignal.1159433

DO - 10.1126/scisignal.1159433

M3 - Journal article

C2 - 18765831

VL - 1

SP - ra2

JO - Science Signaling

JF - Science Signaling

SN - 1945-0877

IS - 35

ER -

ID: 40740054