Left Ventricular Noncompaction in Childhood

Left Ventricular Noncompaction in Childhood: Echocardiographic Follow-Up and Prevalence in First-Degree Relatives

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Left Ventricular Noncompaction in Childhood : Echocardiographic Follow-Up and Prevalence in First-Degree Relatives. / Kock, Thilde O.; Børresen, Marie F.; Sillesen, Anne Sophie; Vøgg, Ruth O.B.; Norsk, Jakob B.; Pærregaard, Maria M.; Vejlstrup, Niels G.; Christensen, Alex H.; Iversen, Kasper K.; Bundgaard, Henning; Axelsson Raja, Anna.

In: JACC: Advances, Vol. 3, No. 3, 100829, 2024.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kock, TO, Børresen, MF, Sillesen, AS, Vøgg, ROB, Norsk, JB, Pærregaard, MM, Vejlstrup, NG, Christensen, AH, Iversen, KK, Bundgaard, H & Axelsson Raja, A 2024, 'Left Ventricular Noncompaction in Childhood: Echocardiographic Follow-Up and Prevalence in First-Degree Relatives', JACC: Advances, vol. 3, no. 3, 100829. https://doi.org/10.1016/j.jacadv.2024.100829

APA

Kock, T. O., Børresen, M. F., Sillesen, A. S., Vøgg, R. O. B., Norsk, J. B., Pærregaard, M. M., Vejlstrup, N. G., Christensen, A. H., Iversen, K. K., Bundgaard, H., & Axelsson Raja, A. (2024). Left Ventricular Noncompaction in Childhood: Echocardiographic Follow-Up and Prevalence in First-Degree Relatives. JACC: Advances, 3(3), [100829]. https://doi.org/10.1016/j.jacadv.2024.100829

Vancouver

Kock TO, Børresen MF, Sillesen AS, Vøgg ROB, Norsk JB, Pærregaard MM et al. Left Ventricular Noncompaction in Childhood: Echocardiographic Follow-Up and Prevalence in First-Degree Relatives. JACC: Advances. 2024;3(3). 100829. https://doi.org/10.1016/j.jacadv.2024.100829

Author

Kock, Thilde O. ; Børresen, Marie F. ; Sillesen, Anne Sophie ; Vøgg, Ruth O.B. ; Norsk, Jakob B. ; Pærregaard, Maria M. ; Vejlstrup, Niels G. ; Christensen, Alex H. ; Iversen, Kasper K. ; Bundgaard, Henning ; Axelsson Raja, Anna. / Left Ventricular Noncompaction in Childhood : Echocardiographic Follow-Up and Prevalence in First-Degree Relatives. In: JACC: Advances. 2024 ; Vol. 3, No. 3.

Bibtex

@article{339372f9320c4bb1bbaa8063b7878a88,

title = "Left Ventricular Noncompaction in Childhood: Echocardiographic Follow-Up and Prevalence in First-Degree Relatives",

abstract = "Background: Left ventricular noncompaction (LVNC) is characterized by excessive trabeculations of the left ventricular (LV) wall. Objectives: The authors aimed to examine changes in LV function and morphology in 2 to 4-year-old children with and without LVNC at birth and to describe the prevalence of LVNC in first-degree relatives. Methods: Echocardiograms in children with and without LVNC (matched 1:4) were performed at 2 to 4 years and in first-degree relatives. LVNC was blindly assessed and defined as a ratio of non-compact to compact myocardium of ≥2 in ≥1 LV segment. Trabeculations were expressed as a percentage of the number of segments with LVNC out of the total number of segments. Results: In total, 14 (median age 3 years, 71% male) of 16 children with LVNC at birth and 56 children without (median age 4 years, 71% male), 37 first-degree relatives of children with LVNC (median age 31 years, 46% male) and 146 first-degree relatives of children without (median age 33 years, 50% male) were included. In children with LVNC, trabeculation (8% vs 13%, P = 0.81) and LV ejection fraction (50% vs 49%, P = 0.91) were unchanged from birth to follow-up but LV ejection fraction was lower compared to children without LVNC (49% vs 60%, P < 0.001). In relatives of children with LVNC, 11 of 37 (30%) fulfilled LVNC criteria compared to no relatives to children without LVNC (P < 0.001). Conclusions: At 2 to 4 years, children with LVNC diagnosed at birth had reduced systolic function compared to children without but did not have progression of LV dysfunction or extent of trabeculations. In first-degree relatives to children with LVNC, 30% fulfilled criteria.",

keywords = "cardiomyopathy, child, echocardiography, myocardium, trabeculation",

author = "Kock, {Thilde O.} and B{\o}rresen, {Marie F.} and Sillesen, {Anne Sophie} and V{\o}gg, {Ruth O.B.} and Norsk, {Jakob B.} and P{\ae}rregaard, {Maria M.} and Vejlstrup, {Niels G.} and Christensen, {Alex H.} and Iversen, {Kasper K.} and Henning Bundgaard and {Axelsson Raja}, Anna",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors",

year = "2024",

doi = "10.1016/j.jacadv.2024.100829",

language = "English",

volume = "3",

journal = "JACC: Advances",

issn = "2772-963X",

publisher = "Elsevier",

number = "3",

}

RIS

TY - JOUR

T1 - Left Ventricular Noncompaction in Childhood

T2 - Echocardiographic Follow-Up and Prevalence in First-Degree Relatives

AU - Kock, Thilde O.

AU - Børresen, Marie F.

AU - Sillesen, Anne Sophie

AU - Vøgg, Ruth O.B.

AU - Norsk, Jakob B.

AU - Pærregaard, Maria M.

AU - Vejlstrup, Niels G.

AU - Christensen, Alex H.

AU - Iversen, Kasper K.

AU - Bundgaard, Henning

AU - Axelsson Raja, Anna

PY - 2024

Y1 - 2024

N2 - Background: Left ventricular noncompaction (LVNC) is characterized by excessive trabeculations of the left ventricular (LV) wall. Objectives: The authors aimed to examine changes in LV function and morphology in 2 to 4-year-old children with and without LVNC at birth and to describe the prevalence of LVNC in first-degree relatives. Methods: Echocardiograms in children with and without LVNC (matched 1:4) were performed at 2 to 4 years and in first-degree relatives. LVNC was blindly assessed and defined as a ratio of non-compact to compact myocardium of ≥2 in ≥1 LV segment. Trabeculations were expressed as a percentage of the number of segments with LVNC out of the total number of segments. Results: In total, 14 (median age 3 years, 71% male) of 16 children with LVNC at birth and 56 children without (median age 4 years, 71% male), 37 first-degree relatives of children with LVNC (median age 31 years, 46% male) and 146 first-degree relatives of children without (median age 33 years, 50% male) were included. In children with LVNC, trabeculation (8% vs 13%, P = 0.81) and LV ejection fraction (50% vs 49%, P = 0.91) were unchanged from birth to follow-up but LV ejection fraction was lower compared to children without LVNC (49% vs 60%, P < 0.001). In relatives of children with LVNC, 11 of 37 (30%) fulfilled LVNC criteria compared to no relatives to children without LVNC (P < 0.001). Conclusions: At 2 to 4 years, children with LVNC diagnosed at birth had reduced systolic function compared to children without but did not have progression of LV dysfunction or extent of trabeculations. In first-degree relatives to children with LVNC, 30% fulfilled criteria.

AB - Background: Left ventricular noncompaction (LVNC) is characterized by excessive trabeculations of the left ventricular (LV) wall. Objectives: The authors aimed to examine changes in LV function and morphology in 2 to 4-year-old children with and without LVNC at birth and to describe the prevalence of LVNC in first-degree relatives. Methods: Echocardiograms in children with and without LVNC (matched 1:4) were performed at 2 to 4 years and in first-degree relatives. LVNC was blindly assessed and defined as a ratio of non-compact to compact myocardium of ≥2 in ≥1 LV segment. Trabeculations were expressed as a percentage of the number of segments with LVNC out of the total number of segments. Results: In total, 14 (median age 3 years, 71% male) of 16 children with LVNC at birth and 56 children without (median age 4 years, 71% male), 37 first-degree relatives of children with LVNC (median age 31 years, 46% male) and 146 first-degree relatives of children without (median age 33 years, 50% male) were included. In children with LVNC, trabeculation (8% vs 13%, P = 0.81) and LV ejection fraction (50% vs 49%, P = 0.91) were unchanged from birth to follow-up but LV ejection fraction was lower compared to children without LVNC (49% vs 60%, P < 0.001). In relatives of children with LVNC, 11 of 37 (30%) fulfilled LVNC criteria compared to no relatives to children without LVNC (P < 0.001). Conclusions: At 2 to 4 years, children with LVNC diagnosed at birth had reduced systolic function compared to children without but did not have progression of LV dysfunction or extent of trabeculations. In first-degree relatives to children with LVNC, 30% fulfilled criteria.

KW - cardiomyopathy

KW - child

KW - echocardiography

KW - myocardium

KW - trabeculation

U2 - 10.1016/j.jacadv.2024.100829

DO - 10.1016/j.jacadv.2024.100829

M3 - Journal article

C2 - 38938835

AN - SCOPUS:85184783781

VL - 3

JO - JACC: Advances

JF - JACC: Advances

SN - 2772-963X

IS - 3

M1 - 100829

ER -

ID: 384570777