Latex allergy and filaggrin null mutations
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Latex allergy and filaggrin null mutations. / Carlsen, Berit C; Meldgaard, Michael; Hamann, Dathan; Hamann, Quinlan; Hamann, Carsten; Thyssen, Jacob P; Meyer, Daniel M; Gruninger, Stephen E; Hamann, Curt.
In: International Journal of Dentistry, Vol. 39, No. 2, 01.02.2011, p. 128-32.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Latex allergy and filaggrin null mutations
AU - Carlsen, Berit C
AU - Meldgaard, Michael
AU - Hamann, Dathan
AU - Hamann, Quinlan
AU - Hamann, Carsten
AU - Thyssen, Jacob P
AU - Meyer, Daniel M
AU - Gruninger, Stephen E
AU - Hamann, Curt
N1 - Copyright © 2010 Elsevier Ltd. All rights reserved.
PY - 2011/2/1
Y1 - 2011/2/1
N2 - Objectives Natural rubber latex (NRL) contains over 200 proteins of which 13 have been identified as allergens and the cause of type I latex allergy. Health care workers share a high occupational risk for developing latex allergy. Filaggrin null mutations increase the risk of type I sensitizations to aeroallergens and it is possible that filaggrin null mutations also increase the risk of latex allergy. The aim of this paper was to examine the association between filaggrin null mutations and type I latex allergy. Methods Twenty latex allergic and 24 non-latex allergic dentists and dental assistants, occupationally exposed to latex, were genotyped for filaggrin null mutations R501X and 2282del4. Latex allergy was determined by a positive reaction or a historical positive reaction to a skin prick test with NRL. Results 41 individuals were successfully genotyped. Three individuals were filaggrin mutation carriers. One (2.4%) was a 2282del4 heterozygote and two (4.9%) were R501X heterozygote. No homozygote or compound heterozygote carriers were detected. No association between filaggrin null mutations and type I latex allergy was found (p=0.24). Patients with type I latex allergy more often reported contact dermatitis. Conclusions This is the first study to examine a highly plausible association between filaggrin null mutations and type I latex allergy. The study subjects were occupationally exposed to latex but no association between latex allergy and filaggrin mutations were detected. Sensitization to latex in the cases in this study may not have occurred through direct skin contact but through the respiratory organs via latex proteins that are absorbed in glove powder and aerosolized
AB - Objectives Natural rubber latex (NRL) contains over 200 proteins of which 13 have been identified as allergens and the cause of type I latex allergy. Health care workers share a high occupational risk for developing latex allergy. Filaggrin null mutations increase the risk of type I sensitizations to aeroallergens and it is possible that filaggrin null mutations also increase the risk of latex allergy. The aim of this paper was to examine the association between filaggrin null mutations and type I latex allergy. Methods Twenty latex allergic and 24 non-latex allergic dentists and dental assistants, occupationally exposed to latex, were genotyped for filaggrin null mutations R501X and 2282del4. Latex allergy was determined by a positive reaction or a historical positive reaction to a skin prick test with NRL. Results 41 individuals were successfully genotyped. Three individuals were filaggrin mutation carriers. One (2.4%) was a 2282del4 heterozygote and two (4.9%) were R501X heterozygote. No homozygote or compound heterozygote carriers were detected. No association between filaggrin null mutations and type I latex allergy was found (p=0.24). Patients with type I latex allergy more often reported contact dermatitis. Conclusions This is the first study to examine a highly plausible association between filaggrin null mutations and type I latex allergy. The study subjects were occupationally exposed to latex but no association between latex allergy and filaggrin mutations were detected. Sensitization to latex in the cases in this study may not have occurred through direct skin contact but through the respiratory organs via latex proteins that are absorbed in glove powder and aerosolized
U2 - 10.1016/j.jdent.2010.11.001
DO - 10.1016/j.jdent.2010.11.001
M3 - Journal article
C2 - 21074596
VL - 39
SP - 128
EP - 132
JO - International Journal of Dentistry
JF - International Journal of Dentistry
SN - 1687-8728
IS - 2
ER -
ID: 34093877