Lactase Persistence, Milk Intake, and Adult Acne: A Mendelian Randomization Study of 20,416 Danish Adults

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Standard

Lactase Persistence, Milk Intake, and Adult Acne : A Mendelian Randomization Study of 20,416 Danish Adults. / Juhl, Christian R; Bergholdt, Helle K M; Miller, Iben M; Jemec, Gregor B E; Kanters, Jørgen K; Ellervik, Christina.

In: Nutrients, Vol. 10, No. 8, 1041, 08.08.2018.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Juhl, CR, Bergholdt, HKM, Miller, IM, Jemec, GBE, Kanters, JK & Ellervik, C 2018, 'Lactase Persistence, Milk Intake, and Adult Acne: A Mendelian Randomization Study of 20,416 Danish Adults', Nutrients, vol. 10, no. 8, 1041. https://doi.org/10.3390/nu10081041

APA

Juhl, C. R., Bergholdt, H. K. M., Miller, I. M., Jemec, G. B. E., Kanters, J. K., & Ellervik, C. (2018). Lactase Persistence, Milk Intake, and Adult Acne: A Mendelian Randomization Study of 20,416 Danish Adults. Nutrients, 10(8), [1041]. https://doi.org/10.3390/nu10081041

Vancouver

Juhl CR, Bergholdt HKM, Miller IM, Jemec GBE, Kanters JK, Ellervik C. Lactase Persistence, Milk Intake, and Adult Acne: A Mendelian Randomization Study of 20,416 Danish Adults. Nutrients. 2018 Aug 8;10(8). 1041. https://doi.org/10.3390/nu10081041

Author

Juhl, Christian R ; Bergholdt, Helle K M ; Miller, Iben M ; Jemec, Gregor B E ; Kanters, Jørgen K ; Ellervik, Christina. / Lactase Persistence, Milk Intake, and Adult Acne : A Mendelian Randomization Study of 20,416 Danish Adults. In: Nutrients. 2018 ; Vol. 10, No. 8.

Bibtex

@article{a735faf6280547189171fcc56faa7b69,
title = "Lactase Persistence, Milk Intake, and Adult Acne: A Mendelian Randomization Study of 20,416 Danish Adults",
abstract = "Whether there is a causal relationship between milk intake and acne is unknown. We tested the hypothesis that genetically determined milk intake is associated with acne in adults using a Mendelian randomization design. LCT-13910 C/T (rs4988235) is associated with lactase persistence (TT/TC) in Northern Europeans. We investigated the association between milk intake, LCT-13910 C/T (rs4988235), and acne in 20,416 adults (age-range: 20⁻96) from The Danish General Suburban Population Study (GESUS). The adjusted observational odds ratio for acne in any milk intake vs. no milk intake was 0.93(95% confidence interval: 0.48⁻1.78) in females and 0.49(0.22⁻1.08) in males aged 20⁻39 years, and 1.15(95% confidence interval: 0.66⁻1.99) in females and 1.02(0.61⁻1.72) in males above 40 years. The unadjusted odds ratio for acne in TT+TC vs. CC was 0.84(0.43⁻1.62) in the age group 20⁻39 years, and 0.99(0.52⁻1.88) above 40 years. We did not find any observational or genetic association between milk intake and acne in our population of adults.",
keywords = "Acne, Acne vulgaris, Adults, Dairy, Diet, Mendelian randomization, Milk",
author = "Juhl, {Christian R} and Bergholdt, {Helle K M} and Miller, {Iben M} and Jemec, {Gregor B E} and Kanters, {J{\o}rgen K} and Christina Ellervik",
year = "2018",
month = aug,
day = "8",
doi = "10.3390/nu10081041",
language = "English",
volume = "10",
journal = "Nutrients",
issn = "2072-6643",
publisher = "M D P I AG",
number = "8",

}

RIS

TY - JOUR

T1 - Lactase Persistence, Milk Intake, and Adult Acne

T2 - A Mendelian Randomization Study of 20,416 Danish Adults

AU - Juhl, Christian R

AU - Bergholdt, Helle K M

AU - Miller, Iben M

AU - Jemec, Gregor B E

AU - Kanters, Jørgen K

AU - Ellervik, Christina

PY - 2018/8/8

Y1 - 2018/8/8

N2 - Whether there is a causal relationship between milk intake and acne is unknown. We tested the hypothesis that genetically determined milk intake is associated with acne in adults using a Mendelian randomization design. LCT-13910 C/T (rs4988235) is associated with lactase persistence (TT/TC) in Northern Europeans. We investigated the association between milk intake, LCT-13910 C/T (rs4988235), and acne in 20,416 adults (age-range: 20⁻96) from The Danish General Suburban Population Study (GESUS). The adjusted observational odds ratio for acne in any milk intake vs. no milk intake was 0.93(95% confidence interval: 0.48⁻1.78) in females and 0.49(0.22⁻1.08) in males aged 20⁻39 years, and 1.15(95% confidence interval: 0.66⁻1.99) in females and 1.02(0.61⁻1.72) in males above 40 years. The unadjusted odds ratio for acne in TT+TC vs. CC was 0.84(0.43⁻1.62) in the age group 20⁻39 years, and 0.99(0.52⁻1.88) above 40 years. We did not find any observational or genetic association between milk intake and acne in our population of adults.

AB - Whether there is a causal relationship between milk intake and acne is unknown. We tested the hypothesis that genetically determined milk intake is associated with acne in adults using a Mendelian randomization design. LCT-13910 C/T (rs4988235) is associated with lactase persistence (TT/TC) in Northern Europeans. We investigated the association between milk intake, LCT-13910 C/T (rs4988235), and acne in 20,416 adults (age-range: 20⁻96) from The Danish General Suburban Population Study (GESUS). The adjusted observational odds ratio for acne in any milk intake vs. no milk intake was 0.93(95% confidence interval: 0.48⁻1.78) in females and 0.49(0.22⁻1.08) in males aged 20⁻39 years, and 1.15(95% confidence interval: 0.66⁻1.99) in females and 1.02(0.61⁻1.72) in males above 40 years. The unadjusted odds ratio for acne in TT+TC vs. CC was 0.84(0.43⁻1.62) in the age group 20⁻39 years, and 0.99(0.52⁻1.88) above 40 years. We did not find any observational or genetic association between milk intake and acne in our population of adults.

KW - Acne

KW - Acne vulgaris

KW - Adults

KW - Dairy

KW - Diet

KW - Mendelian randomization

KW - Milk

UR - http://www.scopus.com/inward/record.url?scp=85051390176&partnerID=8YFLogxK

U2 - 10.3390/nu10081041

DO - 10.3390/nu10081041

M3 - Journal article

C2 - 30096803

VL - 10

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 8

M1 - 1041

ER -

ID: 204296354