Lack of gender-specific antibody recognition of products from domains of a var gene implicated in pregnancy-associated Plasmodium falciparum malaria
Research output: Contribution to journal › Journal article › Research › peer-review
Gender-specific and parity-dependent acquired antibody recognition is characteristic of variant surface antigens (VSA) expressed by chondroitin sulfate A (CSA)-adherent Plasmodium falciparum involved in pregnancy-associated malaria (PAM). However, antibody recognition of recombinant products of a specific VSA gene (2O2var1) implicated in PAM and transcribed by a CSA-adhering parasite line did not have these characteristics. Furthermore, we could not demonstrate preferential transcription of 2O2var1 in the CSA-adhering line versus the unselected, parental isolate. Our data call for circumspection regarding the molecular identity of the parasite ligand mediating adhesion to CSA in PAM.
Original language | English |
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Journal | Infection and Immunity |
Volume | 71 |
Issue number | 7 |
Pages (from-to) | 4193-6 |
Number of pages | 3 |
ISSN | 0019-9567 |
DOIs | |
Publication status | Published - 2003 |
Bibliographical note
Keywords: Animals; Antibodies, Protozoan; Chondroitin Sulfates; Female; Humans; Immunoglobulin G; Malaria, Falciparum; Male; Parity; Plasmodium falciparum; Pregnancy; Pregnancy Complications, Parasitic; Protozoan Proteins; Sex Factors
ID: 5831862