KLIFS: an overhaul after the first 5 years of supporting kinase research

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

KLIFS : an overhaul after the first 5 years of supporting kinase research. / Kanev, Georgi K; de Graaf, Chris; Westerman, Bart A; de Esch, Iwan J P; Kooistra, Albert J.

In: Nucleic Acids Research, Vol. 49, No. D1, 2021, p. D562-D569.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kanev, GK, de Graaf, C, Westerman, BA, de Esch, IJP & Kooistra, AJ 2021, 'KLIFS: an overhaul after the first 5 years of supporting kinase research', Nucleic Acids Research, vol. 49, no. D1, pp. D562-D569. https://doi.org/10.1093/nar/gkaa895

APA

Kanev, G. K., de Graaf, C., Westerman, B. A., de Esch, I. J. P., & Kooistra, A. J. (2021). KLIFS: an overhaul after the first 5 years of supporting kinase research. Nucleic Acids Research, 49(D1), D562-D569. https://doi.org/10.1093/nar/gkaa895

Vancouver

Kanev GK, de Graaf C, Westerman BA, de Esch IJP, Kooistra AJ. KLIFS: an overhaul after the first 5 years of supporting kinase research. Nucleic Acids Research. 2021;49(D1):D562-D569. https://doi.org/10.1093/nar/gkaa895

Author

Kanev, Georgi K ; de Graaf, Chris ; Westerman, Bart A ; de Esch, Iwan J P ; Kooistra, Albert J. / KLIFS : an overhaul after the first 5 years of supporting kinase research. In: Nucleic Acids Research. 2021 ; Vol. 49, No. D1. pp. D562-D569.

Bibtex

@article{bc6166050b2040369483faf53b9022f3,
title = "KLIFS: an overhaul after the first 5 years of supporting kinase research",
abstract = "Kinases are a prime target of drug development efforts with >60 drug approvals in the past two decades. Due to the research into this protein family, a wealth of data has been accumulated that keeps on growing. KLIFS-Kinase-Ligand Interaction Fingerprints and Structures-is a structural database focusing on how kinase inhibitors interact with their targets. The aim of KLIFS is to support (structure-based) kinase research through the systematic collection, annotation, and processing of kinase structures. Now, 5 years after releasing the initial KLIFS website, the database has undergone a complete overhaul with a new website, new logo, and new functionalities. In this article, we start by looking back at how KLIFS has been used by the research community, followed by a description of the renewed KLIFS, and conclude with showcasing the functionalities of KLIFS. Major changes include the integration of approved drugs and inhibitors in clinical trials, extension of the coverage to atypical kinases, and a RESTful API for programmatic access. KLIFS is available at the new domain https://klifs.net.",
author = "Kanev, {Georgi K} and {de Graaf}, Chris and Westerman, {Bart A} and {de Esch}, {Iwan J P} and Kooistra, {Albert J}",
note = "{\textcopyright} The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.",
year = "2021",
doi = "10.1093/nar/gkaa895",
language = "English",
volume = "49",
pages = "D562--D569",
journal = "Nucleic Acids Research",
issn = "0305-1048",
publisher = "Oxford University Press",
number = "D1",

}

RIS

TY - JOUR

T1 - KLIFS

T2 - an overhaul after the first 5 years of supporting kinase research

AU - Kanev, Georgi K

AU - de Graaf, Chris

AU - Westerman, Bart A

AU - de Esch, Iwan J P

AU - Kooistra, Albert J

N1 - © The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

PY - 2021

Y1 - 2021

N2 - Kinases are a prime target of drug development efforts with >60 drug approvals in the past two decades. Due to the research into this protein family, a wealth of data has been accumulated that keeps on growing. KLIFS-Kinase-Ligand Interaction Fingerprints and Structures-is a structural database focusing on how kinase inhibitors interact with their targets. The aim of KLIFS is to support (structure-based) kinase research through the systematic collection, annotation, and processing of kinase structures. Now, 5 years after releasing the initial KLIFS website, the database has undergone a complete overhaul with a new website, new logo, and new functionalities. In this article, we start by looking back at how KLIFS has been used by the research community, followed by a description of the renewed KLIFS, and conclude with showcasing the functionalities of KLIFS. Major changes include the integration of approved drugs and inhibitors in clinical trials, extension of the coverage to atypical kinases, and a RESTful API for programmatic access. KLIFS is available at the new domain https://klifs.net.

AB - Kinases are a prime target of drug development efforts with >60 drug approvals in the past two decades. Due to the research into this protein family, a wealth of data has been accumulated that keeps on growing. KLIFS-Kinase-Ligand Interaction Fingerprints and Structures-is a structural database focusing on how kinase inhibitors interact with their targets. The aim of KLIFS is to support (structure-based) kinase research through the systematic collection, annotation, and processing of kinase structures. Now, 5 years after releasing the initial KLIFS website, the database has undergone a complete overhaul with a new website, new logo, and new functionalities. In this article, we start by looking back at how KLIFS has been used by the research community, followed by a description of the renewed KLIFS, and conclude with showcasing the functionalities of KLIFS. Major changes include the integration of approved drugs and inhibitors in clinical trials, extension of the coverage to atypical kinases, and a RESTful API for programmatic access. KLIFS is available at the new domain https://klifs.net.

U2 - 10.1093/nar/gkaa895

DO - 10.1093/nar/gkaa895

M3 - Journal article

C2 - 33084889

VL - 49

SP - D562-D569

JO - Nucleic Acids Research

JF - Nucleic Acids Research

SN - 0305-1048

IS - D1

ER -

ID: 255109621