Kinetics of reaction of peroxynitrite with selenium- and sulfur-containing compounds: Absolute rate constants and assessment of biological significance

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Kinetics of reaction of peroxynitrite with selenium- and sulfur-containing compounds : Absolute rate constants and assessment of biological significance. / Storkey, Corin; Pattison, David I.; Ignasiak, Marta T.; Schiesser, Carl H.; Davies, Michael J.

In: Free Radical Biology & Medicine, Vol. 89, 12.2015, p. 1049-1056.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Storkey, C, Pattison, DI, Ignasiak, MT, Schiesser, CH & Davies, MJ 2015, 'Kinetics of reaction of peroxynitrite with selenium- and sulfur-containing compounds: Absolute rate constants and assessment of biological significance', Free Radical Biology & Medicine, vol. 89, pp. 1049-1056. https://doi.org/10.1016/j.freeradbiomed.2015.10.424

APA

Storkey, C., Pattison, D. I., Ignasiak, M. T., Schiesser, C. H., & Davies, M. J. (2015). Kinetics of reaction of peroxynitrite with selenium- and sulfur-containing compounds: Absolute rate constants and assessment of biological significance. Free Radical Biology & Medicine, 89, 1049-1056. https://doi.org/10.1016/j.freeradbiomed.2015.10.424

Vancouver

Storkey C, Pattison DI, Ignasiak MT, Schiesser CH, Davies MJ. Kinetics of reaction of peroxynitrite with selenium- and sulfur-containing compounds: Absolute rate constants and assessment of biological significance. Free Radical Biology & Medicine. 2015 Dec;89:1049-1056. https://doi.org/10.1016/j.freeradbiomed.2015.10.424

Author

Storkey, Corin ; Pattison, David I. ; Ignasiak, Marta T. ; Schiesser, Carl H. ; Davies, Michael J. / Kinetics of reaction of peroxynitrite with selenium- and sulfur-containing compounds : Absolute rate constants and assessment of biological significance. In: Free Radical Biology & Medicine. 2015 ; Vol. 89. pp. 1049-1056.

Bibtex

@article{5616d273cd954862b89317ddb1689028,
title = "Kinetics of reaction of peroxynitrite with selenium- and sulfur-containing compounds: Absolute rate constants and assessment of biological significance",
abstract = "Peroxynitrite (the physiological mixture of ONOOH and its anion, ONOO-) is a powerful biologically-relevant oxidant capable of oxidizing and damaging a range of important targets including sulfides, thiols, lipids, proteins, carbohydrates and nucleic acids. Excessive production of peroxynitrite is associated with several human pathologies including cardiovascular disease, ischemic-reperfusion injury, circulatory shock, inflammation and neurodegeneration. This study demonstrates that low-molecular-mass selenols (RSeH), selenides (RSeR') and to a lesser extent diselenides (RSeSeR') react with peroxynitrite with high rate constants. Low molecular mass selenols react particularly rapidly with peroxynitrite, with second order rate constants k2 in the range 5.1×105-1.9×106 M-1 s-1, and 250-830 fold faster than the corresponding thiols (RSH) and many other endogenous biological targets. Reactions of peroxynitrite with selenides, including selenosugars are approximately 15-fold faster than their sulfur homologs with k2 approximately 2.5×103 M-1 s-1. The rate constants for diselenides and sulfides were slower with k2 0.72-1.3×103 M-1 s-1 and approximately 2.1×102 M-1 s-1 respectively. These studies demonstrate that both endogenous and exogenous selenium-containing compounds may modulate peroxynitrite-mediated damage at sites of acute and chronic inflammation, with this being of particular relevance at extracellular sites where the thiol pool is limited.",
author = "Corin Storkey and Pattison, {David I.} and Ignasiak, {Marta T.} and Schiesser, {Carl H.} and Davies, {Michael J.}",
note = "Copyright {\circledC} 2015 Elsevier Inc. All rights reserved.",
year = "2015",
month = "12",
doi = "10.1016/j.freeradbiomed.2015.10.424",
language = "English",
volume = "89",
pages = "1049--1056",
journal = "Free Radical Biology & Medicine",
issn = "0891-5849",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Kinetics of reaction of peroxynitrite with selenium- and sulfur-containing compounds

T2 - Absolute rate constants and assessment of biological significance

AU - Storkey, Corin

AU - Pattison, David I.

AU - Ignasiak, Marta T.

AU - Schiesser, Carl H.

AU - Davies, Michael J.

N1 - Copyright © 2015 Elsevier Inc. All rights reserved.

PY - 2015/12

Y1 - 2015/12

N2 - Peroxynitrite (the physiological mixture of ONOOH and its anion, ONOO-) is a powerful biologically-relevant oxidant capable of oxidizing and damaging a range of important targets including sulfides, thiols, lipids, proteins, carbohydrates and nucleic acids. Excessive production of peroxynitrite is associated with several human pathologies including cardiovascular disease, ischemic-reperfusion injury, circulatory shock, inflammation and neurodegeneration. This study demonstrates that low-molecular-mass selenols (RSeH), selenides (RSeR') and to a lesser extent diselenides (RSeSeR') react with peroxynitrite with high rate constants. Low molecular mass selenols react particularly rapidly with peroxynitrite, with second order rate constants k2 in the range 5.1×105-1.9×106 M-1 s-1, and 250-830 fold faster than the corresponding thiols (RSH) and many other endogenous biological targets. Reactions of peroxynitrite with selenides, including selenosugars are approximately 15-fold faster than their sulfur homologs with k2 approximately 2.5×103 M-1 s-1. The rate constants for diselenides and sulfides were slower with k2 0.72-1.3×103 M-1 s-1 and approximately 2.1×102 M-1 s-1 respectively. These studies demonstrate that both endogenous and exogenous selenium-containing compounds may modulate peroxynitrite-mediated damage at sites of acute and chronic inflammation, with this being of particular relevance at extracellular sites where the thiol pool is limited.

AB - Peroxynitrite (the physiological mixture of ONOOH and its anion, ONOO-) is a powerful biologically-relevant oxidant capable of oxidizing and damaging a range of important targets including sulfides, thiols, lipids, proteins, carbohydrates and nucleic acids. Excessive production of peroxynitrite is associated with several human pathologies including cardiovascular disease, ischemic-reperfusion injury, circulatory shock, inflammation and neurodegeneration. This study demonstrates that low-molecular-mass selenols (RSeH), selenides (RSeR') and to a lesser extent diselenides (RSeSeR') react with peroxynitrite with high rate constants. Low molecular mass selenols react particularly rapidly with peroxynitrite, with second order rate constants k2 in the range 5.1×105-1.9×106 M-1 s-1, and 250-830 fold faster than the corresponding thiols (RSH) and many other endogenous biological targets. Reactions of peroxynitrite with selenides, including selenosugars are approximately 15-fold faster than their sulfur homologs with k2 approximately 2.5×103 M-1 s-1. The rate constants for diselenides and sulfides were slower with k2 0.72-1.3×103 M-1 s-1 and approximately 2.1×102 M-1 s-1 respectively. These studies demonstrate that both endogenous and exogenous selenium-containing compounds may modulate peroxynitrite-mediated damage at sites of acute and chronic inflammation, with this being of particular relevance at extracellular sites where the thiol pool is limited.

U2 - 10.1016/j.freeradbiomed.2015.10.424

DO - 10.1016/j.freeradbiomed.2015.10.424

M3 - Journal article

C2 - 26524402

VL - 89

SP - 1049

EP - 1056

JO - Free Radical Biology & Medicine

JF - Free Radical Biology & Medicine

SN - 0891-5849

ER -

ID: 152247052