Kinetics of 5-aminosalicylic acid after jejunal instillation in man
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Kinetics of 5-aminosalicylic acid after jejunal instillation in man. / Haagen Nielsen, O; Bondesen, S.
In: British Journal of Clinical Pharmacology. Supplement, Vol. 16, No. 6, 12.1983, p. 738-40.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Kinetics of 5-aminosalicylic acid after jejunal instillation in man
AU - Haagen Nielsen, O
AU - Bondesen, S
PY - 1983/12
Y1 - 1983/12
N2 - The human pharmacokinetics of 5-aminosalicylic acid (5-ASA), the active moiety of salazosulphapyridine (SASP), is only known from studies in which rapid absorption has been deliberately avoided. The present investigation demonstrates that pure 5-ASA is absorbed extremely quickly when given as an instillation in the proximal part of the small bowel, and acetylation follows immediately. The metabolite is excreted very rapidly by the liver in small amounts, while the major part is eliminated renally.
AB - The human pharmacokinetics of 5-aminosalicylic acid (5-ASA), the active moiety of salazosulphapyridine (SASP), is only known from studies in which rapid absorption has been deliberately avoided. The present investigation demonstrates that pure 5-ASA is absorbed extremely quickly when given as an instillation in the proximal part of the small bowel, and acetylation follows immediately. The metabolite is excreted very rapidly by the liver in small amounts, while the major part is eliminated renally.
KW - Acetylation
KW - Adult
KW - Aminosalicylic Acids/administration & dosage
KW - Female
KW - Humans
KW - Intestinal Absorption
KW - Jejunum/metabolism
KW - Kinetics
KW - Male
KW - Mesalamine
U2 - 10.1111/j.1365-2125.1983.tb02254.x
DO - 10.1111/j.1365-2125.1983.tb02254.x
M3 - Journal article
C2 - 6661362
VL - 16
SP - 738
EP - 740
JO - British Journal of Clinical Pharmacology, Supplement
JF - British Journal of Clinical Pharmacology, Supplement
SN - 0264-3774
IS - 6
ER -
ID: 219533969