Kinetics of 5-aminosalicylic acid after jejunal instillation in man

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Kinetics of 5-aminosalicylic acid after jejunal instillation in man. / Haagen Nielsen, O; Bondesen, S.

In: British Journal of Clinical Pharmacology. Supplement, Vol. 16, No. 6, 12.1983, p. 738-40.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Haagen Nielsen, O & Bondesen, S 1983, 'Kinetics of 5-aminosalicylic acid after jejunal instillation in man', British Journal of Clinical Pharmacology. Supplement, vol. 16, no. 6, pp. 738-40. https://doi.org/10.1111/j.1365-2125.1983.tb02254.x

APA

Haagen Nielsen, O., & Bondesen, S. (1983). Kinetics of 5-aminosalicylic acid after jejunal instillation in man. British Journal of Clinical Pharmacology. Supplement, 16(6), 738-40. https://doi.org/10.1111/j.1365-2125.1983.tb02254.x

Vancouver

Haagen Nielsen O, Bondesen S. Kinetics of 5-aminosalicylic acid after jejunal instillation in man. British Journal of Clinical Pharmacology. Supplement. 1983 Dec;16(6):738-40. https://doi.org/10.1111/j.1365-2125.1983.tb02254.x

Author

Haagen Nielsen, O ; Bondesen, S. / Kinetics of 5-aminosalicylic acid after jejunal instillation in man. In: British Journal of Clinical Pharmacology. Supplement. 1983 ; Vol. 16, No. 6. pp. 738-40.

Bibtex

@article{522134f34c8b4a19ac59d5d72e92dce1,
title = "Kinetics of 5-aminosalicylic acid after jejunal instillation in man",
abstract = "The human pharmacokinetics of 5-aminosalicylic acid (5-ASA), the active moiety of salazosulphapyridine (SASP), is only known from studies in which rapid absorption has been deliberately avoided. The present investigation demonstrates that pure 5-ASA is absorbed extremely quickly when given as an instillation in the proximal part of the small bowel, and acetylation follows immediately. The metabolite is excreted very rapidly by the liver in small amounts, while the major part is eliminated renally.",
keywords = "Acetylation, Adult, Aminosalicylic Acids/administration & dosage, Female, Humans, Intestinal Absorption, Jejunum/metabolism, Kinetics, Male, Mesalamine",
author = "{Haagen Nielsen}, O and S Bondesen",
year = "1983",
month = "12",
doi = "10.1111/j.1365-2125.1983.tb02254.x",
language = "English",
volume = "16",
pages = "738--40",
journal = "British Journal of Clinical Pharmacology. Supplement",
issn = "0264-3774",
publisher = "Wiley-Blackwell",
number = "6",

}

RIS

TY - JOUR

T1 - Kinetics of 5-aminosalicylic acid after jejunal instillation in man

AU - Haagen Nielsen, O

AU - Bondesen, S

PY - 1983/12

Y1 - 1983/12

N2 - The human pharmacokinetics of 5-aminosalicylic acid (5-ASA), the active moiety of salazosulphapyridine (SASP), is only known from studies in which rapid absorption has been deliberately avoided. The present investigation demonstrates that pure 5-ASA is absorbed extremely quickly when given as an instillation in the proximal part of the small bowel, and acetylation follows immediately. The metabolite is excreted very rapidly by the liver in small amounts, while the major part is eliminated renally.

AB - The human pharmacokinetics of 5-aminosalicylic acid (5-ASA), the active moiety of salazosulphapyridine (SASP), is only known from studies in which rapid absorption has been deliberately avoided. The present investigation demonstrates that pure 5-ASA is absorbed extremely quickly when given as an instillation in the proximal part of the small bowel, and acetylation follows immediately. The metabolite is excreted very rapidly by the liver in small amounts, while the major part is eliminated renally.

KW - Acetylation

KW - Adult

KW - Aminosalicylic Acids/administration & dosage

KW - Female

KW - Humans

KW - Intestinal Absorption

KW - Jejunum/metabolism

KW - Kinetics

KW - Male

KW - Mesalamine

U2 - 10.1111/j.1365-2125.1983.tb02254.x

DO - 10.1111/j.1365-2125.1983.tb02254.x

M3 - Journal article

C2 - 6661362

VL - 16

SP - 738

EP - 740

JO - British Journal of Clinical Pharmacology. Supplement

JF - British Journal of Clinical Pharmacology. Supplement

SN - 0264-3774

IS - 6

ER -

ID: 219533969