Is There an Association Between Ambient Air Pollution and Bladder Cancer Incidence? Analysis of 15 European Cohorts
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Is There an Association Between Ambient Air Pollution and Bladder Cancer Incidence? Analysis of 15 European Cohorts. / Pedersen, Marie; Stafoggia, Massimo; Weinmayr, Gudrun; Andersen, Zorana J.; Galassi, Claudia; Sommar, Johan; Forsberg, Bertil; Olsson, David; Oftedal, Bente; Krog, Norun H.; Aamodt, Geir; Pyko, Andrei; Pershagen, Göran; Korek, Michal; De Faire, Ulf; Pedersen, Nancy L.; Östenson, Claes-göran; Fratiglioni, Laura; Sørensen, Mette; Eriksen, Kirsten T.; Tjønneland, Anne; Peeters, Petra H.; Bueno-de-mesquita, Bas; Vermeulen, Roel; Eeftens, Marloes; Plusquin, Michelle; Key, Timothy J.; Jaensch, Andrea; Nagel, Gabriele; Concin, Hans; Wang, Meng; Tsai, Ming-yi; Grioni, Sara; Marcon, Alessandro; Krogh, Vittorio; Ricceri, Fulvio; Sacerdote, Carlotta; Ranzi, Andrea; Cesaroni, Giulia; Forastiere, Francesco; Tamayo, Ibon; Amiano, Pilar; Dorronsoro, Miren; Stayner, Leslie T.; Kogevinas, Manolis; Nieuwenhuijsen, Mark J.; Sokhi, Ranjeet; De Hoogh, Kees; Beelen, Rob; Vineis, Paolo; Brunekreef, Bert; Hoek, Gerard; Raaschou-nielsen, Ole.
In: European Urology Focus, Vol. 4, No. 1, 2018, p. 113-120.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Is There an Association Between Ambient Air Pollution and Bladder Cancer Incidence?
T2 - Analysis of 15 European Cohorts
AU - Pedersen, Marie
AU - Stafoggia, Massimo
AU - Weinmayr, Gudrun
AU - Andersen, Zorana J.
AU - Galassi, Claudia
AU - Sommar, Johan
AU - Forsberg, Bertil
AU - Olsson, David
AU - Oftedal, Bente
AU - Krog, Norun H.
AU - Aamodt, Geir
AU - Pyko, Andrei
AU - Pershagen, Göran
AU - Korek, Michal
AU - De Faire, Ulf
AU - Pedersen, Nancy L.
AU - Östenson, Claes-göran
AU - Fratiglioni, Laura
AU - Sørensen, Mette
AU - Eriksen, Kirsten T.
AU - Tjønneland, Anne
AU - Peeters, Petra H.
AU - Bueno-de-mesquita, Bas
AU - Vermeulen, Roel
AU - Eeftens, Marloes
AU - Plusquin, Michelle
AU - Key, Timothy J.
AU - Jaensch, Andrea
AU - Nagel, Gabriele
AU - Concin, Hans
AU - Wang, Meng
AU - Tsai, Ming-yi
AU - Grioni, Sara
AU - Marcon, Alessandro
AU - Krogh, Vittorio
AU - Ricceri, Fulvio
AU - Sacerdote, Carlotta
AU - Ranzi, Andrea
AU - Cesaroni, Giulia
AU - Forastiere, Francesco
AU - Tamayo, Ibon
AU - Amiano, Pilar
AU - Dorronsoro, Miren
AU - Stayner, Leslie T.
AU - Kogevinas, Manolis
AU - Nieuwenhuijsen, Mark J.
AU - Sokhi, Ranjeet
AU - De Hoogh, Kees
AU - Beelen, Rob
AU - Vineis, Paolo
AU - Brunekreef, Bert
AU - Hoek, Gerard
AU - Raaschou-nielsen, Ole
PY - 2018
Y1 - 2018
N2 - Background: Ambient air pollution contains low concentrations of carcinogens implicated in the etiology of urinary bladder cancer (BC). Little is known about whether exposure to air pollution influences BC in the general population.Objective: To evaluate the association between long-term exposure to ambient airpollution and BC incidence.Design, setting, and participants: We obtained data from 15 population-based cohorts enrolled between 1985 and 2005 in eight European countries (N = 303 431; meanfollow-up 14.1 yr). We estimated exposure to nitrogen oxides (NO2 and NOx), particulate matter (PM) with diameter <10 mm (PM10), <2.5 mm (PM2.5), between 2.5 and 10 mm (PM2.5–10), PM2.5 absorbance (soot), elemental constituents of PM, organic carbon, and traffic density at baseline home addresses using standardized land-use regression models from the European Study of Cohorts for Air Pollution Effects project.Outcome measurements and statistical analysis: We used Cox proportional-hazards models with adjustment for potential confounders for cohort-specific analyses and meta-analyses to estimate summary hazard ratios (HRs) for BC incidence.Results and limitations: During follow-up, 943 incident BC cases were diagnosed. In the meta-analysis, none of the exposures were associated with BC risk. The summary HRs associated with a 10-mg/m3 increase in NO2 and 5-mg/m3 increase in PM2.5 were 0.98 (95% confidence interval [CI] 0.89–1.08) and 0.86 (95% CI 0.63–1.18), respectively.Limitations include the lack of information about lifetime exposure.Conclusions: There was no evidence of an association between exposure to outdoor air pollution levels at place of residence and risk of BC.Patient summary: We assessed the link between outdoor air pollution at place of residence and bladder cancer using the largest study population to date and extensive assessment of exposure and comprehensive data on personal risk factors such as smoking. We found no association between the levels of outdoor air pollution at placeof residence and bladder cancer risk.
AB - Background: Ambient air pollution contains low concentrations of carcinogens implicated in the etiology of urinary bladder cancer (BC). Little is known about whether exposure to air pollution influences BC in the general population.Objective: To evaluate the association between long-term exposure to ambient airpollution and BC incidence.Design, setting, and participants: We obtained data from 15 population-based cohorts enrolled between 1985 and 2005 in eight European countries (N = 303 431; meanfollow-up 14.1 yr). We estimated exposure to nitrogen oxides (NO2 and NOx), particulate matter (PM) with diameter <10 mm (PM10), <2.5 mm (PM2.5), between 2.5 and 10 mm (PM2.5–10), PM2.5 absorbance (soot), elemental constituents of PM, organic carbon, and traffic density at baseline home addresses using standardized land-use regression models from the European Study of Cohorts for Air Pollution Effects project.Outcome measurements and statistical analysis: We used Cox proportional-hazards models with adjustment for potential confounders for cohort-specific analyses and meta-analyses to estimate summary hazard ratios (HRs) for BC incidence.Results and limitations: During follow-up, 943 incident BC cases were diagnosed. In the meta-analysis, none of the exposures were associated with BC risk. The summary HRs associated with a 10-mg/m3 increase in NO2 and 5-mg/m3 increase in PM2.5 were 0.98 (95% confidence interval [CI] 0.89–1.08) and 0.86 (95% CI 0.63–1.18), respectively.Limitations include the lack of information about lifetime exposure.Conclusions: There was no evidence of an association between exposure to outdoor air pollution levels at place of residence and risk of BC.Patient summary: We assessed the link between outdoor air pollution at place of residence and bladder cancer using the largest study population to date and extensive assessment of exposure and comprehensive data on personal risk factors such as smoking. We found no association between the levels of outdoor air pollution at placeof residence and bladder cancer risk.
U2 - 10.1016/j.euf.2016.11.008
DO - 10.1016/j.euf.2016.11.008
M3 - Journal article
C2 - 28753823
VL - 4
SP - 113
EP - 120
JO - European Urology Focus
JF - European Urology Focus
SN - 2405-4569
IS - 1
ER -
ID: 173751001