Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging?

Research output: Contribution to journalJournal articlepeer-review

Standard

Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging? / Hansen, Thomas Lau; Rasmussen, Lene Juel; Madsen, Claus Desler; Frederiksen, Jane Bruun; Espersen, Maiken Lise Marcker; Singh, Keshav K.

In: Journal of Aging Research, Vol. 2012, 2012, p. 192503.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Hansen, TL, Rasmussen, LJ, Madsen, CD, Frederiksen, JB, Espersen, MLM & Singh, KK 2012, 'Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging?', Journal of Aging Research, vol. 2012, pp. 192503. https://doi.org/10.1155/2012/192503

APA

Hansen, T. L., Rasmussen, L. J., Madsen, C. D., Frederiksen, J. B., Espersen, M. L. M., & Singh, K. K. (2012). Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging? Journal of Aging Research, 2012, 192503. https://doi.org/10.1155/2012/192503

Vancouver

Hansen TL, Rasmussen LJ, Madsen CD, Frederiksen JB, Espersen MLM, Singh KK. Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging? Journal of Aging Research. 2012;2012:192503. https://doi.org/10.1155/2012/192503

Author

Hansen, Thomas Lau ; Rasmussen, Lene Juel ; Madsen, Claus Desler ; Frederiksen, Jane Bruun ; Espersen, Maiken Lise Marcker ; Singh, Keshav K. / Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging?. In: Journal of Aging Research. 2012 ; Vol. 2012. pp. 192503.

Bibtex

@article{1fbdf7d3fb1d4871bc677b902dc4064b,
title = "Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging?",
abstract = "Oxidative phosphorylation is an indispensable resource of ATP in tissues with high requirement of energy. If the ATP demand is not met, studies suggest that this will lead to senescence and cell death in the affected tissue. The term reserve respiratory capacity or spare respiratory capacity is used to describe the amount of extra ATP that can be produced by oxidative phosphorylation in case of a sudden increase in energy demand. Depletion of the reserve respiratory capacity has been related to a range of pathologies affecting high energy requiring tissues. During aging of an organism, and as a result of mitochondrial dysfunctions, the efficiency of oxidative phosphorylation declines. Based on examples from the energy requiring tissues such as brain, heart, and skeletal muscle, we propose that the age-related decline of oxidative phosphorylation decreases the reserve respiratory capacity of the affected tissue, sensitizes the cells to surges in ATP demand, and increases the risk of resulting pathologies.",
author = "Hansen, {Thomas Lau} and Rasmussen, {Lene Juel} and Madsen, {Claus Desler} and Frederiksen, {Jane Bruun} and Espersen, {Maiken Lise Marcker} and Singh, {Keshav K.}",
year = "2012",
doi = "10.1155/2012/192503",
language = "English",
volume = "2012",
pages = "192503",
journal = "Journal of Aging Research",
issn = "2090-2204",
publisher = "Hindawi Publishing Corporation",

}

RIS

TY - JOUR

T1 - Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging?

AU - Hansen, Thomas Lau

AU - Rasmussen, Lene Juel

AU - Madsen, Claus Desler

AU - Frederiksen, Jane Bruun

AU - Espersen, Maiken Lise Marcker

AU - Singh, Keshav K.

PY - 2012

Y1 - 2012

N2 - Oxidative phosphorylation is an indispensable resource of ATP in tissues with high requirement of energy. If the ATP demand is not met, studies suggest that this will lead to senescence and cell death in the affected tissue. The term reserve respiratory capacity or spare respiratory capacity is used to describe the amount of extra ATP that can be produced by oxidative phosphorylation in case of a sudden increase in energy demand. Depletion of the reserve respiratory capacity has been related to a range of pathologies affecting high energy requiring tissues. During aging of an organism, and as a result of mitochondrial dysfunctions, the efficiency of oxidative phosphorylation declines. Based on examples from the energy requiring tissues such as brain, heart, and skeletal muscle, we propose that the age-related decline of oxidative phosphorylation decreases the reserve respiratory capacity of the affected tissue, sensitizes the cells to surges in ATP demand, and increases the risk of resulting pathologies.

AB - Oxidative phosphorylation is an indispensable resource of ATP in tissues with high requirement of energy. If the ATP demand is not met, studies suggest that this will lead to senescence and cell death in the affected tissue. The term reserve respiratory capacity or spare respiratory capacity is used to describe the amount of extra ATP that can be produced by oxidative phosphorylation in case of a sudden increase in energy demand. Depletion of the reserve respiratory capacity has been related to a range of pathologies affecting high energy requiring tissues. During aging of an organism, and as a result of mitochondrial dysfunctions, the efficiency of oxidative phosphorylation declines. Based on examples from the energy requiring tissues such as brain, heart, and skeletal muscle, we propose that the age-related decline of oxidative phosphorylation decreases the reserve respiratory capacity of the affected tissue, sensitizes the cells to surges in ATP demand, and increases the risk of resulting pathologies.

U2 - 10.1155/2012/192503

DO - 10.1155/2012/192503

M3 - Journal article

C2 - 22720157

VL - 2012

SP - 192503

JO - Journal of Aging Research

JF - Journal of Aging Research

SN - 2090-2204

ER -

ID: 38379152