TY - CONF

T1 - Ionophores in the Environment

AU - Bak, Søren Alex

AU - Hansen, Martin

AU - Björklund, Erland

AU - Halling-Sørensen, Bent

PY - 2010/5/24

Y1 - 2010/5/24

N2 - Questions have arisen about the effects of veterinary medicines and especially their metabolites have on organisms in the environment. A couple of recent investigations has further reported that metabolites of certain veterinary drugs such as antibacterial agents (i.e. tetracyclines) and antiparacitics (i.e. ionophores) posses an environmental effects of similar level as their parent compounds on i.e. the soil bacterial community (Halling-Sørensen et al.2002; Hansen et al. 2009). Ionophores are used extensively worldwide as prophylactic chemotherapeutics and growth promoters in livestock production. Ionophores are antibiotic drugs that form lipid soluble complexes with, primarily, alkali cations that inhibit or kill pathogenic parasites in livestock. Several reports have revealed that ionophores are emerging environmental contaminants in agricultural run-off waters, surface waters, sediments, and ground waters, due to their continuously increased and constant application as feed additives in modern livestock production. This presentation will focus on the development of new analytical method for determination of ionophores in liquid and solid matrices. The hyphenated method consist of pressurised liquid extraction with integrated clean-up followed by solid phase extraction and high-performance liquid chromatography tandem in space mass spectrometry (PLE-SPE-LC-MS/MS).Halling-Sørensen B, Sengelov G, Tjornelund J (2002) Arch Environ Contam Toxicol, 42: 3, p. 263-271. DOI: 10.1007/s00244-001-0017-2 Hansen M, Krogh KA, Brandt A, Christensen JH, Halling-Sorensen B (2009) Environmental Pollution 157: 2 p. 474-480. DOI:10.1016/j.envpol.2008.09.022

AB - Questions have arisen about the effects of veterinary medicines and especially their metabolites have on organisms in the environment. A couple of recent investigations has further reported that metabolites of certain veterinary drugs such as antibacterial agents (i.e. tetracyclines) and antiparacitics (i.e. ionophores) posses an environmental effects of similar level as their parent compounds on i.e. the soil bacterial community (Halling-Sørensen et al.2002; Hansen et al. 2009). Ionophores are used extensively worldwide as prophylactic chemotherapeutics and growth promoters in livestock production. Ionophores are antibiotic drugs that form lipid soluble complexes with, primarily, alkali cations that inhibit or kill pathogenic parasites in livestock. Several reports have revealed that ionophores are emerging environmental contaminants in agricultural run-off waters, surface waters, sediments, and ground waters, due to their continuously increased and constant application as feed additives in modern livestock production. This presentation will focus on the development of new analytical method for determination of ionophores in liquid and solid matrices. The hyphenated method consist of pressurised liquid extraction with integrated clean-up followed by solid phase extraction and high-performance liquid chromatography tandem in space mass spectrometry (PLE-SPE-LC-MS/MS).Halling-Sørensen B, Sengelov G, Tjornelund J (2002) Arch Environ Contam Toxicol, 42: 3, p. 263-271. DOI: 10.1007/s00244-001-0017-2 Hansen M, Krogh KA, Brandt A, Christensen JH, Halling-Sorensen B (2009) Environmental Pollution 157: 2 p. 474-480. DOI:10.1016/j.envpol.2008.09.022

KW - Former Faculty of Pharmaceutical Sciences

KW - Section of Toxicology and Environmental Chemistry

M3 - Poster

Y2 - 23 May 2010 through 27 May 2010

ER -