Involvement of oxygen-derived free radicals in the pathogenesis of chronic inflammatory bowel disease

Research output: Contribution to journal › Review › Research › peer-review

Standard

Involvement of oxygen-derived free radicals in the pathogenesis of chronic inflammatory bowel disease. / Nielsen, O H; Ahnfelt-Rønne, I.

In: Wiener Klinische Wochenschrift, Vol. 69, No. 21-23, 15.12.1991, p. 995-1000.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Nielsen, OH & Ahnfelt-Rønne, I 1991, 'Involvement of oxygen-derived free radicals in the pathogenesis of chronic inflammatory bowel disease', Wiener Klinische Wochenschrift, vol. 69, no. 21-23, pp. 995-1000.

APA

Nielsen, O. H., & Ahnfelt-Rønne, I. (1991). Involvement of oxygen-derived free radicals in the pathogenesis of chronic inflammatory bowel disease. Wiener Klinische Wochenschrift, 69(21-23), 995-1000.

Vancouver

Nielsen OH, Ahnfelt-Rønne I. Involvement of oxygen-derived free radicals in the pathogenesis of chronic inflammatory bowel disease. Wiener Klinische Wochenschrift. 1991 Dec 15;69(21-23):995-1000.

Author

Nielsen, O H ; Ahnfelt-Rønne, I. / Involvement of oxygen-derived free radicals in the pathogenesis of chronic inflammatory bowel disease. In: Wiener Klinische Wochenschrift. 1991 ; Vol. 69, No. 21-23. pp. 995-1000.

Bibtex

@article{8e71f24ffa8a440a859823292eca8596,
title = "Involvement of oxygen-derived free radicals in the pathogenesis of chronic inflammatory bowel disease",
abstract = "Ulcerative colitis and Crohn's disease are chronic inflammatory bowel diseases. The most widely prescribed drug for treatment of these diseases, sulfasalazine, has been shown to inhibit the activity of free radicals, as the active moiety of sulfasalazine, 5-aminosalicylic acid, is a radical scavenger. This effect of 5-aminosalicylic acid may be of clinical relevance, as a recent study has shown that 5-aminosalicylic acid reacts with oxygen-derived free radicals formed in the intestine in this disease. Reaction with free radicals does not, however, occur in patients with rheumatoid arthritis treated with the same agent. Furthermore, a significant correlation exists between the activity in the intestine of free radicals, as measured by the rate of lipid peroxidation, and the disease activity.",
keywords = "Colitis, Ulcerative/drug therapy, Crohn Disease/drug therapy, Eicosanoids/physiology, Free Radicals, Glucocorticoids/therapeutic use, Humans, Intestinal Mucosa/drug effects, Lipid Peroxidation/drug effects, Oxygen/physiology, Sulfasalazine/therapeutic use",
author = "Nielsen, {O H} and I Ahnfelt-R{\o}nne",
year = "1991",
month = dec,
day = "15",
language = "English",
volume = "69",
pages = "995--1000",
journal = "Wiener Zeitschrift fur innere Medizin und ihre Grenzgebiete",
issn = "0043-5325",
publisher = "Springer Wien",
number = "21-23",

}

RIS

TY - JOUR

T1 - Involvement of oxygen-derived free radicals in the pathogenesis of chronic inflammatory bowel disease

AU - Nielsen, O H

AU - Ahnfelt-Rønne, I

PY - 1991/12/15

Y1 - 1991/12/15

N2 - Ulcerative colitis and Crohn's disease are chronic inflammatory bowel diseases. The most widely prescribed drug for treatment of these diseases, sulfasalazine, has been shown to inhibit the activity of free radicals, as the active moiety of sulfasalazine, 5-aminosalicylic acid, is a radical scavenger. This effect of 5-aminosalicylic acid may be of clinical relevance, as a recent study has shown that 5-aminosalicylic acid reacts with oxygen-derived free radicals formed in the intestine in this disease. Reaction with free radicals does not, however, occur in patients with rheumatoid arthritis treated with the same agent. Furthermore, a significant correlation exists between the activity in the intestine of free radicals, as measured by the rate of lipid peroxidation, and the disease activity.

AB - Ulcerative colitis and Crohn's disease are chronic inflammatory bowel diseases. The most widely prescribed drug for treatment of these diseases, sulfasalazine, has been shown to inhibit the activity of free radicals, as the active moiety of sulfasalazine, 5-aminosalicylic acid, is a radical scavenger. This effect of 5-aminosalicylic acid may be of clinical relevance, as a recent study has shown that 5-aminosalicylic acid reacts with oxygen-derived free radicals formed in the intestine in this disease. Reaction with free radicals does not, however, occur in patients with rheumatoid arthritis treated with the same agent. Furthermore, a significant correlation exists between the activity in the intestine of free radicals, as measured by the rate of lipid peroxidation, and the disease activity.

KW - Colitis, Ulcerative/drug therapy

KW - Crohn Disease/drug therapy

KW - Eicosanoids/physiology

KW - Free Radicals

KW - Glucocorticoids/therapeutic use

KW - Humans

KW - Intestinal Mucosa/drug effects

KW - Lipid Peroxidation/drug effects

KW - Oxygen/physiology

KW - Sulfasalazine/therapeutic use

M3 - Review

C2 - 1686790

VL - 69

SP - 995

EP - 1000

JO - Wiener Zeitschrift fur innere Medizin und ihre Grenzgebiete

JF - Wiener Zeitschrift fur innere Medizin und ihre Grenzgebiete

SN - 0043-5325

IS - 21-23

ER -

ID: 218727734