Interleukin-26 (IL-26) is a novel anti-microbial peptide produced by T cells in response to staphylococcal enterotoxin
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Interleukin-26 (IL-26) is a novel anti-microbial peptide produced by T cells in response to staphylococcal enterotoxin. / Woetmann, Anders; Alhede, Morten; Dabelsteen, Sally; Bjarnsholt, Thomas; Rybtke, Morten; Nastasi, Claudia; Krejsgaard, Thorbjørn; Andersen, Mads Hald; Bonefeld, Charlotte M; Geisler, Carsten; Givskov, Michael; Odum, Niels.
In: OncoTarget, Vol. 9, No. 28, 2018, p. 19481-19489.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Interleukin-26 (IL-26) is a novel anti-microbial peptide produced by T cells in response to staphylococcal enterotoxin
AU - Woetmann, Anders
AU - Alhede, Morten
AU - Dabelsteen, Sally
AU - Bjarnsholt, Thomas
AU - Rybtke, Morten
AU - Nastasi, Claudia
AU - Krejsgaard, Thorbjørn
AU - Andersen, Mads Hald
AU - Bonefeld, Charlotte M
AU - Geisler, Carsten
AU - Givskov, Michael
AU - Odum, Niels
PY - 2018
Y1 - 2018
N2 - Anti-microbial peptides are produced at outer and inner surfaces by epithelia and innate immune cells in response to bacterial infection. Staphylococcus aureus is an enterotoxin producing, Gram-positive pathogen, which is a major cause of soft tissue infections and life-threatening bacteremia and sepsis. Here we show that (i) skin T cells in chronic wounds infected with S. aureus express interleukin-26 (IL-26) in situ, (ii) staphylococcal enterotoxins (SE) trigger IL-26 expression in T cell lines and primary skin T cells, and (iii) IL-26 triggers death and inhibits biofilm formation and growth of S. aureus. Thus, we provide novel evidence that IL-26 is an anti-microbial peptide produced by T cells in response to SE. Accordingly, we propose that IL-26 producing T cells take part in the innate immune response to SE producing S. aureus and thus play a novel role in the primary innate immune defense in addition to their classical role in adaptive immunity.
AB - Anti-microbial peptides are produced at outer and inner surfaces by epithelia and innate immune cells in response to bacterial infection. Staphylococcus aureus is an enterotoxin producing, Gram-positive pathogen, which is a major cause of soft tissue infections and life-threatening bacteremia and sepsis. Here we show that (i) skin T cells in chronic wounds infected with S. aureus express interleukin-26 (IL-26) in situ, (ii) staphylococcal enterotoxins (SE) trigger IL-26 expression in T cell lines and primary skin T cells, and (iii) IL-26 triggers death and inhibits biofilm formation and growth of S. aureus. Thus, we provide novel evidence that IL-26 is an anti-microbial peptide produced by T cells in response to SE. Accordingly, we propose that IL-26 producing T cells take part in the innate immune response to SE producing S. aureus and thus play a novel role in the primary innate immune defense in addition to their classical role in adaptive immunity.
KW - Antimicrobial peptide
KW - Chronic wounds
KW - IL-26
KW - Immune response
KW - Immunity
KW - Immunology: Immunology and Microbiology Section
KW - Staphylococcus aureus enterotoxins
KW - Superantigens staphylococcus pseudomonas
U2 - 10.18632/oncotarget.24603
DO - 10.18632/oncotarget.24603
M3 - Journal article
C2 - 29731960
VL - 9
SP - 19481
EP - 19489
JO - Oncotarget
JF - Oncotarget
SN - 1949-2553
IS - 28
ER -
ID: 197098257