Interleukin-2 receptor alpha and beta chain expression by circulating alpha beta and gamma delta T cells in inflammatory bowel disease
Research output: Contribution to journal › Journal article › Research › peer-review
The pathogenetic role of activated alpha beta and gamma delta T cells in inflammatory bowel disease (IBD) is not well defined. To elucidate this, interleukin-2 receptor (IL-2R) alpha and IL-2R beta single chain expression and coexpression by peripheral blood TCR alpha beta + cells and TCR gamma delta + cells was studied in 21 patients with ulcerative colitis (UC), 25 with Crohn's disease (CD), and 15 controls. The percentages of IL-2R alpha + beta-, IL-2R alpha-beta +, and IL-2R alpha + beta + TCR alpha beta + cells were increased in IBD patients with moderate and severe disease activity, as compared to controls (P < 0.01). In contrast, the percentages of IL-2R alpha-beta + and IL-2R alpha + beta + TCR gamma delta + cells were increased in patients with inactive UC (P < 0.01), but not in CD. The results suggest that activated alpha beta T cells are involved in the development of IBD. The differences in gamma delta T cell IL-2R expression between inactive UC and CD may correspond to a yet undefined etiopathogenetic difference between these two diseases.
|Journal||Digestive Diseases and Sciences|
|Number of pages||5|
|Publication status||Published - Feb 1995|
- Adolescent, Adult, Colitis, Ulcerative/etiology, Crohn Disease/etiology, Female, Humans, Immunophenotyping, Inflammatory Bowel Diseases/etiology, Male, Middle Aged, Receptors, Antigen, T-Cell, alpha-beta/analysis, Receptors, Antigen, T-Cell, gamma-delta/analysis, Receptors, Interleukin-2/analysis, T-Lymphocytes/immunology