Interleukin-2 receptor alpha and beta chain expression by circulating alpha beta and gamma delta T cells in inflammatory bowel disease
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Interleukin-2 receptor alpha and beta chain expression by circulating alpha beta and gamma delta T cells in inflammatory bowel disease. / Kirman, I; Nielsen, O H; Kjaersgaard, E; Brynskov, J.
In: Digestive Diseases and Sciences, Vol. 40, No. 2, 02.1995, p. 291-5.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Interleukin-2 receptor alpha and beta chain expression by circulating alpha beta and gamma delta T cells in inflammatory bowel disease
AU - Kirman, I
AU - Nielsen, O H
AU - Kjaersgaard, E
AU - Brynskov, J
PY - 1995/2
Y1 - 1995/2
N2 - The pathogenetic role of activated alpha beta and gamma delta T cells in inflammatory bowel disease (IBD) is not well defined. To elucidate this, interleukin-2 receptor (IL-2R) alpha and IL-2R beta single chain expression and coexpression by peripheral blood TCR alpha beta + cells and TCR gamma delta + cells was studied in 21 patients with ulcerative colitis (UC), 25 with Crohn's disease (CD), and 15 controls. The percentages of IL-2R alpha + beta-, IL-2R alpha-beta +, and IL-2R alpha + beta + TCR alpha beta + cells were increased in IBD patients with moderate and severe disease activity, as compared to controls (P < 0.01). In contrast, the percentages of IL-2R alpha-beta + and IL-2R alpha + beta + TCR gamma delta + cells were increased in patients with inactive UC (P < 0.01), but not in CD. The results suggest that activated alpha beta T cells are involved in the development of IBD. The differences in gamma delta T cell IL-2R expression between inactive UC and CD may correspond to a yet undefined etiopathogenetic difference between these two diseases.
AB - The pathogenetic role of activated alpha beta and gamma delta T cells in inflammatory bowel disease (IBD) is not well defined. To elucidate this, interleukin-2 receptor (IL-2R) alpha and IL-2R beta single chain expression and coexpression by peripheral blood TCR alpha beta + cells and TCR gamma delta + cells was studied in 21 patients with ulcerative colitis (UC), 25 with Crohn's disease (CD), and 15 controls. The percentages of IL-2R alpha + beta-, IL-2R alpha-beta +, and IL-2R alpha + beta + TCR alpha beta + cells were increased in IBD patients with moderate and severe disease activity, as compared to controls (P < 0.01). In contrast, the percentages of IL-2R alpha-beta + and IL-2R alpha + beta + TCR gamma delta + cells were increased in patients with inactive UC (P < 0.01), but not in CD. The results suggest that activated alpha beta T cells are involved in the development of IBD. The differences in gamma delta T cell IL-2R expression between inactive UC and CD may correspond to a yet undefined etiopathogenetic difference between these two diseases.
KW - Adolescent
KW - Adult
KW - Colitis, Ulcerative/etiology
KW - Crohn Disease/etiology
KW - Female
KW - Humans
KW - Immunophenotyping
KW - Inflammatory Bowel Diseases/etiology
KW - Male
KW - Middle Aged
KW - Receptors, Antigen, T-Cell, alpha-beta/analysis
KW - Receptors, Antigen, T-Cell, gamma-delta/analysis
KW - Receptors, Interleukin-2/analysis
KW - T-Lymphocytes/immunology
M3 - Journal article
C2 - 7851192
VL - 40
SP - 291
EP - 295
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
SN - 0163-2116
IS - 2
ER -
ID: 218727259