Inhibitors of histone demethylases

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Inhibitors of histone demethylases. / Lohse, Brian; Kristensen, Jesper L; Kristensen, Line H; Agger, Karl; Helin, Kristian; Gajhede, Michael; Clausen, Rasmus P.

In: Bioorganic & Medicinal Chemistry, Vol. 19, No. 12, 01.02.2011, p. 3625-3636.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Lohse, B, Kristensen, JL, Kristensen, LH, Agger, K, Helin, K, Gajhede, M & Clausen, RP 2011, 'Inhibitors of histone demethylases', Bioorganic & Medicinal Chemistry, vol. 19, no. 12, pp. 3625-3636. https://doi.org/10.1016/j.bmc.2011.01.046

APA

Lohse, B., Kristensen, J. L., Kristensen, L. H., Agger, K., Helin, K., Gajhede, M., & Clausen, R. P. (2011). Inhibitors of histone demethylases. Bioorganic & Medicinal Chemistry, 19(12), 3625-3636. https://doi.org/10.1016/j.bmc.2011.01.046

Vancouver

Lohse B, Kristensen JL, Kristensen LH, Agger K, Helin K, Gajhede M et al. Inhibitors of histone demethylases. Bioorganic & Medicinal Chemistry. 2011 Feb 1;19(12):3625-3636. https://doi.org/10.1016/j.bmc.2011.01.046

Author

Lohse, Brian ; Kristensen, Jesper L ; Kristensen, Line H ; Agger, Karl ; Helin, Kristian ; Gajhede, Michael ; Clausen, Rasmus P. / Inhibitors of histone demethylases. In: Bioorganic & Medicinal Chemistry. 2011 ; Vol. 19, No. 12. pp. 3625-3636.

Bibtex

@article{d41b67311a6e4fe1b770f7850ddb7058,

title = "Inhibitors of histone demethylases",

abstract = "Methylated lysines are important epigenetic marks. The enzymes involved in demethylation have recently been discovered and found to be involved in cancer development and progression. Despite the relative recent discovery of these enzymes a number of inhibitors have already appeared. Most of the inhibitors are either previously reported inhibitors of related enzymes or compounds derived from these. Development in terms of selectivity and potency is still pertinent. Several reports on the development of functional assays have been published.",

author = "Brian Lohse and Kristensen, {Jesper L} and Kristensen, {Line H} and Karl Agger and Kristian Helin and Michael Gajhede and Clausen, {Rasmus P}",

year = "2011",

month = feb,

day = "1",

doi = "10.1016/j.bmc.2011.01.046",

language = "English",

volume = "19",

pages = "3625--3636",

journal = "Bioorganic & Medicinal Chemistry",

issn = "0968-0896",

publisher = "Pergamon Press",

number = "12",

}

RIS

TY - JOUR

T1 - Inhibitors of histone demethylases

AU - Lohse, Brian

AU - Kristensen, Jesper L

AU - Kristensen, Line H

AU - Agger, Karl

AU - Helin, Kristian

AU - Gajhede, Michael

AU - Clausen, Rasmus P

PY - 2011/2/1

Y1 - 2011/2/1

N2 - Methylated lysines are important epigenetic marks. The enzymes involved in demethylation have recently been discovered and found to be involved in cancer development and progression. Despite the relative recent discovery of these enzymes a number of inhibitors have already appeared. Most of the inhibitors are either previously reported inhibitors of related enzymes or compounds derived from these. Development in terms of selectivity and potency is still pertinent. Several reports on the development of functional assays have been published.

AB - Methylated lysines are important epigenetic marks. The enzymes involved in demethylation have recently been discovered and found to be involved in cancer development and progression. Despite the relative recent discovery of these enzymes a number of inhibitors have already appeared. Most of the inhibitors are either previously reported inhibitors of related enzymes or compounds derived from these. Development in terms of selectivity and potency is still pertinent. Several reports on the development of functional assays have been published.

U2 - 10.1016/j.bmc.2011.01.046

DO - 10.1016/j.bmc.2011.01.046

M3 - Review

C2 - 21596573

VL - 19

SP - 3625

EP - 3636

JO - Bioorganic & Medicinal Chemistry

JF - Bioorganic & Medicinal Chemistry

SN - 0968-0896

IS - 12

ER -

ID: 33531805