Influence of preparation pathway on the glass forming ability

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Influence of preparation pathway on the glass forming ability. / Blaabjerg, Lasse Ingerslev; Lindenberg, Eleanor; Rades, Thomas; Grohganz, Holger; Löbmann, Korbinian.

In: International Journal of Pharmaceutics, Vol. 521, No. 1-2, 21.04.2017, p. 232-238.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Blaabjerg, LI, Lindenberg, E, Rades, T, Grohganz, H & Löbmann, K 2017, 'Influence of preparation pathway on the glass forming ability', International Journal of Pharmaceutics, vol. 521, no. 1-2, pp. 232-238. https://doi.org/10.1016/j.ijpharm.2017.02.042

APA

Blaabjerg, L. I., Lindenberg, E., Rades, T., Grohganz, H., & Löbmann, K. (2017). Influence of preparation pathway on the glass forming ability. International Journal of Pharmaceutics, 521(1-2), 232-238. https://doi.org/10.1016/j.ijpharm.2017.02.042

Vancouver

Blaabjerg LI, Lindenberg E, Rades T, Grohganz H, Löbmann K. Influence of preparation pathway on the glass forming ability. International Journal of Pharmaceutics. 2017 Apr 21;521(1-2):232-238. https://doi.org/10.1016/j.ijpharm.2017.02.042

Author

Blaabjerg, Lasse Ingerslev ; Lindenberg, Eleanor ; Rades, Thomas ; Grohganz, Holger ; Löbmann, Korbinian. / Influence of preparation pathway on the glass forming ability. In: International Journal of Pharmaceutics. 2017 ; Vol. 521, No. 1-2. pp. 232-238.

Bibtex

@article{c3effc4dc35649148fc12f90979f953c,

title = "Influence of preparation pathway on the glass forming ability",

abstract = "The glass forming ability (GFA), i.e. the ease of amorphization of drugs, is mostly investigated using the critical cooling rate upon melt quenching to generate an amorphous product via the thermodynamic pathway. However, amorphous materials can also be prepared via the kinetic pathway by milling. In this case, the time required to generate an amorphous product is called the minimal milling time. This study investigates the correlation of the GFA between these two pathways. Eighteen compounds were chosen and their GFA was investigated by determining the critical cooling rate and the minimal milling time. It was observed that drugs, which turned amorphous upon cooling from the melt at slow cooling rates also had a low minimal milling time and vice versa. It was found that the GFA of the studied set of drugs was inherent and independent of the preparation method. It can be concluded that a drug with low critical cooling rate will also have a low minimal milling time and is thus a good glass former.",

keywords = "Journal Article",

author = "Blaabjerg, {Lasse Ingerslev} and Eleanor Lindenberg and Thomas Rades and Holger Grohganz and Korbinian L{\"o}bmann",

year = "2017",

month = apr,

day = "21",

doi = "10.1016/j.ijpharm.2017.02.042",

language = "English",

volume = "521",

pages = "232--238",

journal = "International Journal of Pharmaceutics",

issn = "0378-5173",

publisher = "Elsevier",

number = "1-2",

}

RIS

TY - JOUR

T1 - Influence of preparation pathway on the glass forming ability

AU - Blaabjerg, Lasse Ingerslev

AU - Lindenberg, Eleanor

AU - Rades, Thomas

AU - Grohganz, Holger

AU - Löbmann, Korbinian

PY - 2017/4/21

Y1 - 2017/4/21

N2 - The glass forming ability (GFA), i.e. the ease of amorphization of drugs, is mostly investigated using the critical cooling rate upon melt quenching to generate an amorphous product via the thermodynamic pathway. However, amorphous materials can also be prepared via the kinetic pathway by milling. In this case, the time required to generate an amorphous product is called the minimal milling time. This study investigates the correlation of the GFA between these two pathways. Eighteen compounds were chosen and their GFA was investigated by determining the critical cooling rate and the minimal milling time. It was observed that drugs, which turned amorphous upon cooling from the melt at slow cooling rates also had a low minimal milling time and vice versa. It was found that the GFA of the studied set of drugs was inherent and independent of the preparation method. It can be concluded that a drug with low critical cooling rate will also have a low minimal milling time and is thus a good glass former.

AB - The glass forming ability (GFA), i.e. the ease of amorphization of drugs, is mostly investigated using the critical cooling rate upon melt quenching to generate an amorphous product via the thermodynamic pathway. However, amorphous materials can also be prepared via the kinetic pathway by milling. In this case, the time required to generate an amorphous product is called the minimal milling time. This study investigates the correlation of the GFA between these two pathways. Eighteen compounds were chosen and their GFA was investigated by determining the critical cooling rate and the minimal milling time. It was observed that drugs, which turned amorphous upon cooling from the melt at slow cooling rates also had a low minimal milling time and vice versa. It was found that the GFA of the studied set of drugs was inherent and independent of the preparation method. It can be concluded that a drug with low critical cooling rate will also have a low minimal milling time and is thus a good glass former.

KW - Journal Article

U2 - 10.1016/j.ijpharm.2017.02.042

DO - 10.1016/j.ijpharm.2017.02.042

M3 - Journal article

C2 - 28232267

VL - 521

SP - 232

EP - 238

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1-2

ER -

ID: 173710085