Inflammatorisk tarmsygdom--spiller mikroorganismer en rolle?

Research output: Contribution to journalJournal articleResearchpeer-review

This review focuses on the potential pathogenic role of microorganisms in relation to inflammatory bowel diseases, i.e. Crohn's disease and ulcerative colitis. Pathogenic microorganism such as Mycobacterium paratuberculosis, measles and mumps viruses, Epstein-Barr virus, and Listeria monocytogenes are discussed, as well as involvement of the normal intestinal flora. Furthermore, the influence of microorganisms in experimental animal colitis models is discussed. The available results are inconclusive, but there seems to be basis for proposing the hypothesis that the inflammation in inflammatory bowel disease reflects an immune imbalance with loss of tolerance for normally harmless antigens in the mucosal microflora.
Udgivelsesdato: 2002-Dec-9
Original languageDanish
JournalUgeskrift for læger
Volume164
Issue number50
Pages (from-to)5947-50
Number of pages3
ISSN0041-5782
Publication statusPublished - 2002

Bibliographical note

Keywords: Animals; Colitis, Ulcerative; Crohn Disease; Epstein-Barr Virus Infections; Humans; Intestinal Mucosa; Listeria Infections; Listeria monocytogenes; Measles; Mumps; Mycobacterium avium subsp. paratuberculosis; Paratuberculosis

ID: 9747230