Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice

Research output: Contribution to journalJournal articlepeer-review

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Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice. / Lopez-Contreras, Andres J; Specks, Julia; Barlow, Jacqueline H; Ambrogio, Chiara; Madsen, Claus Desler; Vikingsson, Svante; Rodrigo-Perez, Sara; Green, Henrik; Rasmussen, Lene Juel; Murga, Matilde; Nussenzweig, André; Fernandez-Capetillo, Oscar.

In: Genes & Development, Vol. 29, No. 7, 01.04.2015, p. 690-5.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Lopez-Contreras, AJ, Specks, J, Barlow, JH, Ambrogio, C, Madsen, CD, Vikingsson, S, Rodrigo-Perez, S, Green, H, Rasmussen, LJ, Murga, M, Nussenzweig, A & Fernandez-Capetillo, O 2015, 'Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice', Genes & Development, vol. 29, no. 7, pp. 690-5. https://doi.org/10.1101/gad.256958.114

APA

Lopez-Contreras, A. J., Specks, J., Barlow, J. H., Ambrogio, C., Madsen, C. D., Vikingsson, S., Rodrigo-Perez, S., Green, H., Rasmussen, L. J., Murga, M., Nussenzweig, A., & Fernandez-Capetillo, O. (2015). Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice. Genes & Development, 29(7), 690-5. https://doi.org/10.1101/gad.256958.114

Vancouver

Lopez-Contreras AJ, Specks J, Barlow JH, Ambrogio C, Madsen CD, Vikingsson S et al. Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice. Genes & Development. 2015 Apr 1;29(7):690-5. https://doi.org/10.1101/gad.256958.114

Author

Lopez-Contreras, Andres J ; Specks, Julia ; Barlow, Jacqueline H ; Ambrogio, Chiara ; Madsen, Claus Desler ; Vikingsson, Svante ; Rodrigo-Perez, Sara ; Green, Henrik ; Rasmussen, Lene Juel ; Murga, Matilde ; Nussenzweig, André ; Fernandez-Capetillo, Oscar. / Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice. In: Genes & Development. 2015 ; Vol. 29, No. 7. pp. 690-5.

Bibtex

@article{26dfeafa78b04d3d9c6fa73eb063a314,
title = "Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice",
abstract = "In Saccharomyces cerevisiae, absence of the checkpoint kinase Mec1 (ATR) is viable upon mutations that increase the activity of the ribonucleotide reductase (RNR) complex. Whether this pathway is conserved in mammals remains unknown. Here we show that cells from mice carrying extra alleles of the RNR regulatory subunit RRM2 (Rrm2(TG)) present supraphysiological RNR activity and reduced chromosomal breakage at fragile sites. Moreover, increased Rrm2 gene dosage significantly extends the life span of ATR mutant mice. Our study reveals the first genetic condition in mammals that reduces fragile site expression and alleviates the severity of a progeroid disease by increasing RNR activity.",
author = "Lopez-Contreras, {Andres J} and Julia Specks and Barlow, {Jacqueline H} and Chiara Ambrogio and Madsen, {Claus Desler} and Svante Vikingsson and Sara Rodrigo-Perez and Henrik Green and Rasmussen, {Lene Juel} and Matilde Murga and Andr{\'e} Nussenzweig and Oscar Fernandez-Capetillo",
note = "{\textcopyright} 2015 Lopez-Contreras et al.; Published by Cold Spring Harbor Laboratory Press.",
year = "2015",
month = apr,
day = "1",
doi = "10.1101/gad.256958.114",
language = "English",
volume = "29",
pages = "690--5",
journal = "Genes & Development",
issn = "0890-9369",
publisher = "Cold Spring Harbor Laboratory Press",
number = "7",

}

RIS

TY - JOUR

T1 - Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice

AU - Lopez-Contreras, Andres J

AU - Specks, Julia

AU - Barlow, Jacqueline H

AU - Ambrogio, Chiara

AU - Madsen, Claus Desler

AU - Vikingsson, Svante

AU - Rodrigo-Perez, Sara

AU - Green, Henrik

AU - Rasmussen, Lene Juel

AU - Murga, Matilde

AU - Nussenzweig, André

AU - Fernandez-Capetillo, Oscar

N1 - © 2015 Lopez-Contreras et al.; Published by Cold Spring Harbor Laboratory Press.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - In Saccharomyces cerevisiae, absence of the checkpoint kinase Mec1 (ATR) is viable upon mutations that increase the activity of the ribonucleotide reductase (RNR) complex. Whether this pathway is conserved in mammals remains unknown. Here we show that cells from mice carrying extra alleles of the RNR regulatory subunit RRM2 (Rrm2(TG)) present supraphysiological RNR activity and reduced chromosomal breakage at fragile sites. Moreover, increased Rrm2 gene dosage significantly extends the life span of ATR mutant mice. Our study reveals the first genetic condition in mammals that reduces fragile site expression and alleviates the severity of a progeroid disease by increasing RNR activity.

AB - In Saccharomyces cerevisiae, absence of the checkpoint kinase Mec1 (ATR) is viable upon mutations that increase the activity of the ribonucleotide reductase (RNR) complex. Whether this pathway is conserved in mammals remains unknown. Here we show that cells from mice carrying extra alleles of the RNR regulatory subunit RRM2 (Rrm2(TG)) present supraphysiological RNR activity and reduced chromosomal breakage at fragile sites. Moreover, increased Rrm2 gene dosage significantly extends the life span of ATR mutant mice. Our study reveals the first genetic condition in mammals that reduces fragile site expression and alleviates the severity of a progeroid disease by increasing RNR activity.

U2 - 10.1101/gad.256958.114

DO - 10.1101/gad.256958.114

M3 - Journal article

C2 - 25838540

VL - 29

SP - 690

EP - 695

JO - Genes & Development

JF - Genes & Development

SN - 0890-9369

IS - 7

ER -

ID: 135739326