Increased risk of preterm delivery and pre-eclampsia in women with polycystic ovary syndrome and hyperandrogenaemia

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Increased risk of preterm delivery and pre-eclampsia in women with polycystic ovary syndrome and hyperandrogenaemia. / Naver, Klara Vinsand; Grinsted, J; Larsen, S O; Hedley, P L; Jørgensen, Finn Stener; Christiansen, Merete Skovdal; Nilas, L.

In: B J O G, Vol. 121, No. 5, 04.2014, p. 575-581.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Naver, KV, Grinsted, J, Larsen, SO, Hedley, PL, Jørgensen, FS, Christiansen, MS & Nilas, L 2014, 'Increased risk of preterm delivery and pre-eclampsia in women with polycystic ovary syndrome and hyperandrogenaemia', B J O G, vol. 121, no. 5, pp. 575-581. https://doi.org/10.1111/1471-0528.12558

APA

Naver, K. V., Grinsted, J., Larsen, S. O., Hedley, P. L., Jørgensen, F. S., Christiansen, M. S., & Nilas, L. (2014). Increased risk of preterm delivery and pre-eclampsia in women with polycystic ovary syndrome and hyperandrogenaemia. B J O G, 121(5), 575-581. https://doi.org/10.1111/1471-0528.12558

Vancouver

Naver KV, Grinsted J, Larsen SO, Hedley PL, Jørgensen FS, Christiansen MS et al. Increased risk of preterm delivery and pre-eclampsia in women with polycystic ovary syndrome and hyperandrogenaemia. B J O G. 2014 Apr;121(5):575-581. https://doi.org/10.1111/1471-0528.12558

Author

Naver, Klara Vinsand ; Grinsted, J ; Larsen, S O ; Hedley, P L ; Jørgensen, Finn Stener ; Christiansen, Merete Skovdal ; Nilas, L. / Increased risk of preterm delivery and pre-eclampsia in women with polycystic ovary syndrome and hyperandrogenaemia. In: B J O G. 2014 ; Vol. 121, No. 5. pp. 575-581.

Bibtex

@article{1c0e57835d7e4e699f012edc7d94852b,

title = "Increased risk of preterm delivery and pre-eclampsia in women with polycystic ovary syndrome and hyperandrogenaemia",

abstract = "OBJECTIVE: To study the risk of adverse pregnancy outcomes in women with polycystic ovary syndrome (PCOS), and to examine the role of hyperandrogenaemia.DESIGN: Cohort study.SETTING: Singleton pregnancies in women with PCOS identified at a private fertility clinic during 1997-2010 and a background population including all singleton deliveries at Hvidovre Hospital, Denmark, in 2005.POPULATION: A cohort of 459 women with PCOS and a background population of 5409 women.METHODS: Obstetric outcomes were extracted from national Danish registries and odds ratios (ORs) were calculated by multiple logistic regression analysis, adjusting for age, parity, and body mass index.MAIN OUTCOME MEASURES: Risk of pre-eclampsia, preterm delivery, and small for gestational age offspring in the entire PCOS population and in a subsample with hyperandrogenaemia.RESULTS: Women with PCOS had an increased risk of preterm delivery <37 weeks of gestation (OR 2.28; 95% confidence interval, 95% CI, 1.51-3.45; P < 0.0001). The elevated risk was confined to hyperandrogenic women with PCOS: preterm delivery before 37 weeks of gestation (OR 2.78; 95% CI 1.62-4.77; P < 0.0001), and was not seen in normoandrogenic women with PCOS (OR 1.35; 95% CI 0.54-3.39; P = 0.52). The overall risk of pre-eclampsia was not elevated (OR 1.69; 95% CI 0.99-2.88; P = 0.05) compared with the background population, but was significantly increased in the hyperandrogenic subsample (OR 2.41; 95% CI 1.26-4.58; P < 0.001). The risk of small for gestational age offspring was similar in all groups.CONCLUSION: Women with PCOS had an increased risk of preterm delivery compared with the background population. The increased risk was confined to hyperandrogenic women with PCOS who had a two-fold increased risk of preterm delivery and pre-eclampsia.",

keywords = "Adult, Body Mass Index, Case-Control Studies, Cohort Studies, Female, Humans, Hyperandrogenism, Infant, Newborn, Infant, Small for Gestational Age, Maternal Age, Parity, Polycystic Ovary Syndrome, Pre-Eclampsia, Pregnancy, Premature Birth, Regression Analysis",

author = "Naver, {Klara Vinsand} and J Grinsted and Larsen, {S O} and Hedley, {P L} and J{\o}rgensen, {Finn Stener} and Christiansen, {Merete Skovdal} and L Nilas",

note = "{\textcopyright} 2014 Royal College of Obstetricians and Gynaecologists.",

year = "2014",

month = apr,

doi = "10.1111/1471-0528.12558",

language = "English",

volume = "121",

pages = "575--581",

journal = "BJOG: An International Journal of Obstetrics and Gynaecology",

issn = "0140-7686",

publisher = "Wiley-Blackwell",

number = "5",

}

RIS

TY - JOUR

T1 - Increased risk of preterm delivery and pre-eclampsia in women with polycystic ovary syndrome and hyperandrogenaemia

AU - Naver, Klara Vinsand

AU - Grinsted, J

AU - Larsen, S O

AU - Hedley, P L

AU - Jørgensen, Finn Stener

AU - Christiansen, Merete Skovdal

AU - Nilas, L

PY - 2014/4

Y1 - 2014/4

N2 - OBJECTIVE: To study the risk of adverse pregnancy outcomes in women with polycystic ovary syndrome (PCOS), and to examine the role of hyperandrogenaemia.DESIGN: Cohort study.SETTING: Singleton pregnancies in women with PCOS identified at a private fertility clinic during 1997-2010 and a background population including all singleton deliveries at Hvidovre Hospital, Denmark, in 2005.POPULATION: A cohort of 459 women with PCOS and a background population of 5409 women.METHODS: Obstetric outcomes were extracted from national Danish registries and odds ratios (ORs) were calculated by multiple logistic regression analysis, adjusting for age, parity, and body mass index.MAIN OUTCOME MEASURES: Risk of pre-eclampsia, preterm delivery, and small for gestational age offspring in the entire PCOS population and in a subsample with hyperandrogenaemia.RESULTS: Women with PCOS had an increased risk of preterm delivery <37 weeks of gestation (OR 2.28; 95% confidence interval, 95% CI, 1.51-3.45; P < 0.0001). The elevated risk was confined to hyperandrogenic women with PCOS: preterm delivery before 37 weeks of gestation (OR 2.78; 95% CI 1.62-4.77; P < 0.0001), and was not seen in normoandrogenic women with PCOS (OR 1.35; 95% CI 0.54-3.39; P = 0.52). The overall risk of pre-eclampsia was not elevated (OR 1.69; 95% CI 0.99-2.88; P = 0.05) compared with the background population, but was significantly increased in the hyperandrogenic subsample (OR 2.41; 95% CI 1.26-4.58; P < 0.001). The risk of small for gestational age offspring was similar in all groups.CONCLUSION: Women with PCOS had an increased risk of preterm delivery compared with the background population. The increased risk was confined to hyperandrogenic women with PCOS who had a two-fold increased risk of preterm delivery and pre-eclampsia.

AB - OBJECTIVE: To study the risk of adverse pregnancy outcomes in women with polycystic ovary syndrome (PCOS), and to examine the role of hyperandrogenaemia.DESIGN: Cohort study.SETTING: Singleton pregnancies in women with PCOS identified at a private fertility clinic during 1997-2010 and a background population including all singleton deliveries at Hvidovre Hospital, Denmark, in 2005.POPULATION: A cohort of 459 women with PCOS and a background population of 5409 women.METHODS: Obstetric outcomes were extracted from national Danish registries and odds ratios (ORs) were calculated by multiple logistic regression analysis, adjusting for age, parity, and body mass index.MAIN OUTCOME MEASURES: Risk of pre-eclampsia, preterm delivery, and small for gestational age offspring in the entire PCOS population and in a subsample with hyperandrogenaemia.RESULTS: Women with PCOS had an increased risk of preterm delivery <37 weeks of gestation (OR 2.28; 95% confidence interval, 95% CI, 1.51-3.45; P < 0.0001). The elevated risk was confined to hyperandrogenic women with PCOS: preterm delivery before 37 weeks of gestation (OR 2.78; 95% CI 1.62-4.77; P < 0.0001), and was not seen in normoandrogenic women with PCOS (OR 1.35; 95% CI 0.54-3.39; P = 0.52). The overall risk of pre-eclampsia was not elevated (OR 1.69; 95% CI 0.99-2.88; P = 0.05) compared with the background population, but was significantly increased in the hyperandrogenic subsample (OR 2.41; 95% CI 1.26-4.58; P < 0.001). The risk of small for gestational age offspring was similar in all groups.CONCLUSION: Women with PCOS had an increased risk of preterm delivery compared with the background population. The increased risk was confined to hyperandrogenic women with PCOS who had a two-fold increased risk of preterm delivery and pre-eclampsia.

KW - Adult

KW - Body Mass Index

KW - Case-Control Studies

KW - Cohort Studies

KW - Female

KW - Humans

KW - Hyperandrogenism

KW - Infant, Newborn

KW - Infant, Small for Gestational Age

KW - Maternal Age

KW - Parity

KW - Polycystic Ovary Syndrome

KW - Pre-Eclampsia

KW - Pregnancy

KW - Premature Birth

KW - Regression Analysis

U2 - 10.1111/1471-0528.12558

DO - 10.1111/1471-0528.12558

M3 - Journal article

C2 - 24418062

VL - 121

SP - 575

EP - 581

JO - BJOG: An International Journal of Obstetrics and Gynaecology

JF - BJOG: An International Journal of Obstetrics and Gynaecology

SN - 0140-7686

IS - 5

ER -

ID: 138180113