Increased fluorine-18 2-fluoro-2-deoxy-D-glucose (FDG) uptake in childhood CNS tumors is correlated with malignancy grade: a study with FDG positron emission tomography/magnetic resonance imaging coregistration and image fusion

Research output: Contribution to journalJournal articlepeer-review

Standard

Increased fluorine-18 2-fluoro-2-deoxy-D-glucose (FDG) uptake in childhood CNS tumors is correlated with malignancy grade : a study with FDG positron emission tomography/magnetic resonance imaging coregistration and image fusion. / Borgwardt, Lise; Højgaard, Liselotte; Carstensen, Henrik; Laursen, Henning; Nowak, Markus; Thomsen, Carsten; Schmiegelow, Kjeld.

In: Journal of Clinical Oncology, Vol. 23, No. 13, 01.05.2005, p. 3030-7.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Borgwardt, L, Højgaard, L, Carstensen, H, Laursen, H, Nowak, M, Thomsen, C & Schmiegelow, K 2005, 'Increased fluorine-18 2-fluoro-2-deoxy-D-glucose (FDG) uptake in childhood CNS tumors is correlated with malignancy grade: a study with FDG positron emission tomography/magnetic resonance imaging coregistration and image fusion', Journal of Clinical Oncology, vol. 23, no. 13, pp. 3030-7. https://doi.org/10.1200/JCO.2005.02.074

APA

Borgwardt, L., Højgaard, L., Carstensen, H., Laursen, H., Nowak, M., Thomsen, C., & Schmiegelow, K. (2005). Increased fluorine-18 2-fluoro-2-deoxy-D-glucose (FDG) uptake in childhood CNS tumors is correlated with malignancy grade: a study with FDG positron emission tomography/magnetic resonance imaging coregistration and image fusion. Journal of Clinical Oncology, 23(13), 3030-7. https://doi.org/10.1200/JCO.2005.02.074

Vancouver

Borgwardt L, Højgaard L, Carstensen H, Laursen H, Nowak M, Thomsen C et al. Increased fluorine-18 2-fluoro-2-deoxy-D-glucose (FDG) uptake in childhood CNS tumors is correlated with malignancy grade: a study with FDG positron emission tomography/magnetic resonance imaging coregistration and image fusion. Journal of Clinical Oncology. 2005 May 1;23(13):3030-7. https://doi.org/10.1200/JCO.2005.02.074

Author

Borgwardt, Lise ; Højgaard, Liselotte ; Carstensen, Henrik ; Laursen, Henning ; Nowak, Markus ; Thomsen, Carsten ; Schmiegelow, Kjeld. / Increased fluorine-18 2-fluoro-2-deoxy-D-glucose (FDG) uptake in childhood CNS tumors is correlated with malignancy grade : a study with FDG positron emission tomography/magnetic resonance imaging coregistration and image fusion. In: Journal of Clinical Oncology. 2005 ; Vol. 23, No. 13. pp. 3030-7.

Bibtex

@article{fab163c242cf4086828844aea408ff70,
title = "Increased fluorine-18 2-fluoro-2-deoxy-D-glucose (FDG) uptake in childhood CNS tumors is correlated with malignancy grade: a study with FDG positron emission tomography/magnetic resonance imaging coregistration and image fusion",
abstract = "PURPOSE Positron emission tomography (PET) has been used in grading of CNS tumors in adults, whereas studies of children have been limited. PATIENTS AND METHODS Nineteen boys and 19 girls (median age, 8 years) with primary CNS tumors were studied prospectively by fluorine-18 2-fluoro-2-deoxy-D-glucose (FDG) PET with (n = 16) or without (n = 22) H(2)(15)O-PET before therapy. Image processing included coregistration to magnetic resonance imaging (MRI) in all patients. The FDG uptake in tumors was semiquantitatively calculated by a region-of-interest-based tumor hotspot/brain index. Eight tumors without histologic confirmation were classified as WHO grade 1 based on location, MRI, and clinical course (22 to 42 months). Results Four grade 4 tumors had a mean index of 4.27 +/- 0.5, four grade 3 tumors had a mean index of 2.47 +/- 1.07, 10 grade 2 tumors had a mean index of 1.34 +/- 0.73, and eight of 12 grade 1 tumors had a mean index of -0.31 +/- 0.59. Eight patients with no histologic confirmation had a mean index of 1.04. For these 34 tumors, FDG uptake was positively correlated with malignancy grading (n = 34; r = 0.72; P < .01), as for the 26 histologically classified tumors (n = 26; r = 0.89; P < .01). The choroid plexus papilloma (n = 1) and the pilocytic astrocytomas (n = 3) had a mean index of 3.26 (n = 38; r = 0.57; P < .01). H(2)(15)O-uptake showed no correlation with malignancy. Digitally performed PET/MRI coregistration increased information on tumor characterization in 90% of cases. CONCLUSION FDG PET of the brain with MRI coregistration can be used to obtain a more specific diagnosis with respect to malignancy grading. Improved PET/MRI imaging of the benign hypermetabolic tumors is needed to optimize clinical use.",
keywords = "Adolescent, Brain Neoplasms, Child, Child, Preschool, Diagnosis, Differential, Female, Fluorodeoxyglucose F18, Humans, Infant, Infant, Newborn, Magnetic Resonance Imaging, Male, Positron-Emission Tomography, Prospective Studies, Radiopharmaceuticals, Regional Blood Flow, Sensitivity and Specificity, Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't",
author = "Lise Borgwardt and Liselotte H{\o}jgaard and Henrik Carstensen and Henning Laursen and Markus Nowak and Carsten Thomsen and Kjeld Schmiegelow",
year = "2005",
month = may,
day = "1",
doi = "10.1200/JCO.2005.02.074",
language = "English",
volume = "23",
pages = "3030--7",
journal = "Journal of Clinical Oncology",
issn = "0732-183X",
publisher = "American Society of Clinical Oncology",
number = "13",

}

RIS

TY - JOUR

T1 - Increased fluorine-18 2-fluoro-2-deoxy-D-glucose (FDG) uptake in childhood CNS tumors is correlated with malignancy grade

T2 - a study with FDG positron emission tomography/magnetic resonance imaging coregistration and image fusion

AU - Borgwardt, Lise

AU - Højgaard, Liselotte

AU - Carstensen, Henrik

AU - Laursen, Henning

AU - Nowak, Markus

AU - Thomsen, Carsten

AU - Schmiegelow, Kjeld

PY - 2005/5/1

Y1 - 2005/5/1

N2 - PURPOSE Positron emission tomography (PET) has been used in grading of CNS tumors in adults, whereas studies of children have been limited. PATIENTS AND METHODS Nineteen boys and 19 girls (median age, 8 years) with primary CNS tumors were studied prospectively by fluorine-18 2-fluoro-2-deoxy-D-glucose (FDG) PET with (n = 16) or without (n = 22) H(2)(15)O-PET before therapy. Image processing included coregistration to magnetic resonance imaging (MRI) in all patients. The FDG uptake in tumors was semiquantitatively calculated by a region-of-interest-based tumor hotspot/brain index. Eight tumors without histologic confirmation were classified as WHO grade 1 based on location, MRI, and clinical course (22 to 42 months). Results Four grade 4 tumors had a mean index of 4.27 +/- 0.5, four grade 3 tumors had a mean index of 2.47 +/- 1.07, 10 grade 2 tumors had a mean index of 1.34 +/- 0.73, and eight of 12 grade 1 tumors had a mean index of -0.31 +/- 0.59. Eight patients with no histologic confirmation had a mean index of 1.04. For these 34 tumors, FDG uptake was positively correlated with malignancy grading (n = 34; r = 0.72; P < .01), as for the 26 histologically classified tumors (n = 26; r = 0.89; P < .01). The choroid plexus papilloma (n = 1) and the pilocytic astrocytomas (n = 3) had a mean index of 3.26 (n = 38; r = 0.57; P < .01). H(2)(15)O-uptake showed no correlation with malignancy. Digitally performed PET/MRI coregistration increased information on tumor characterization in 90% of cases. CONCLUSION FDG PET of the brain with MRI coregistration can be used to obtain a more specific diagnosis with respect to malignancy grading. Improved PET/MRI imaging of the benign hypermetabolic tumors is needed to optimize clinical use.

AB - PURPOSE Positron emission tomography (PET) has been used in grading of CNS tumors in adults, whereas studies of children have been limited. PATIENTS AND METHODS Nineteen boys and 19 girls (median age, 8 years) with primary CNS tumors were studied prospectively by fluorine-18 2-fluoro-2-deoxy-D-glucose (FDG) PET with (n = 16) or without (n = 22) H(2)(15)O-PET before therapy. Image processing included coregistration to magnetic resonance imaging (MRI) in all patients. The FDG uptake in tumors was semiquantitatively calculated by a region-of-interest-based tumor hotspot/brain index. Eight tumors without histologic confirmation were classified as WHO grade 1 based on location, MRI, and clinical course (22 to 42 months). Results Four grade 4 tumors had a mean index of 4.27 +/- 0.5, four grade 3 tumors had a mean index of 2.47 +/- 1.07, 10 grade 2 tumors had a mean index of 1.34 +/- 0.73, and eight of 12 grade 1 tumors had a mean index of -0.31 +/- 0.59. Eight patients with no histologic confirmation had a mean index of 1.04. For these 34 tumors, FDG uptake was positively correlated with malignancy grading (n = 34; r = 0.72; P < .01), as for the 26 histologically classified tumors (n = 26; r = 0.89; P < .01). The choroid plexus papilloma (n = 1) and the pilocytic astrocytomas (n = 3) had a mean index of 3.26 (n = 38; r = 0.57; P < .01). H(2)(15)O-uptake showed no correlation with malignancy. Digitally performed PET/MRI coregistration increased information on tumor characterization in 90% of cases. CONCLUSION FDG PET of the brain with MRI coregistration can be used to obtain a more specific diagnosis with respect to malignancy grading. Improved PET/MRI imaging of the benign hypermetabolic tumors is needed to optimize clinical use.

KW - Adolescent

KW - Brain Neoplasms

KW - Child

KW - Child, Preschool

KW - Diagnosis, Differential

KW - Female

KW - Fluorodeoxyglucose F18

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Magnetic Resonance Imaging

KW - Male

KW - Positron-Emission Tomography

KW - Prospective Studies

KW - Radiopharmaceuticals

KW - Regional Blood Flow

KW - Sensitivity and Specificity

KW - Clinical Trial

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1200/JCO.2005.02.074

DO - 10.1200/JCO.2005.02.074

M3 - Journal article

C2 - 15860860

VL - 23

SP - 3030

EP - 3037

JO - Journal of Clinical Oncology

JF - Journal of Clinical Oncology

SN - 0732-183X

IS - 13

ER -

ID: 165882246