Increased cerebrovascular pCO2 reactivity in migraine with aura--a transcranial Doppler study during hyperventilation
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Increased cerebrovascular pCO2 reactivity in migraine with aura--a transcranial Doppler study during hyperventilation. / Thomsen, L L; Iversen, Helle Klingenberg; Olesen, J.
In: Cephalalgia : an international journal of headache, Vol. 15, No. 3, 06.1995, p. 211-5.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Increased cerebrovascular pCO2 reactivity in migraine with aura--a transcranial Doppler study during hyperventilation
AU - Thomsen, L L
AU - Iversen, Helle Klingenberg
AU - Olesen, J
PY - 1995/6
Y1 - 1995/6
N2 - Cerebrovascular reactivity during hypocapnia was tested in 20 migraineurs (8 with aura, 12 without aura) and 30 sex- and age-matched healthy subjects, and during nitroglycerin-induced headache in 12 healthy subjects. Before and during hyperventilation, mean blood-flow velocity (Vmean) in the middle cerebral artery was measured with transcranial Doppler. In each subject a pCO2 reactivity index (RI) was calculated as (delta Vmean/baseline Vmean)/delta pCO2. Interictally, patients with migraine with aura showed higher RI (p < 0.05 ANOVA and multiple range test) than controls, whereas migraineurs without aura did not differ from healthy subjects. Ictal and interictal RIs were similar in 9 patients suffering from migraine without aura. No side-to-side differences were detected in RI. During nitroglycerin-induced headache, the RIs were no different from those recorded during migraine attacks and in non-nitroglycerin-provoked healthy controls (p > 0.05, ANOVA and multiple range test). The exaggerated response in migraine with aura might predispose for the characteristic changes in rCBF seen during attacks.
AB - Cerebrovascular reactivity during hypocapnia was tested in 20 migraineurs (8 with aura, 12 without aura) and 30 sex- and age-matched healthy subjects, and during nitroglycerin-induced headache in 12 healthy subjects. Before and during hyperventilation, mean blood-flow velocity (Vmean) in the middle cerebral artery was measured with transcranial Doppler. In each subject a pCO2 reactivity index (RI) was calculated as (delta Vmean/baseline Vmean)/delta pCO2. Interictally, patients with migraine with aura showed higher RI (p < 0.05 ANOVA and multiple range test) than controls, whereas migraineurs without aura did not differ from healthy subjects. Ictal and interictal RIs were similar in 9 patients suffering from migraine without aura. No side-to-side differences were detected in RI. During nitroglycerin-induced headache, the RIs were no different from those recorded during migraine attacks and in non-nitroglycerin-provoked healthy controls (p > 0.05, ANOVA and multiple range test). The exaggerated response in migraine with aura might predispose for the characteristic changes in rCBF seen during attacks.
KW - Adult
KW - Analysis of Variance
KW - Cerebrovascular Circulation
KW - Female
KW - Humans
KW - Hyperventilation
KW - Hypocapnia
KW - Male
KW - Middle Aged
KW - Migraine Disorders
KW - Ultrasonography, Doppler, Transcranial
M3 - Journal article
C2 - 7553811
VL - 15
SP - 211
EP - 215
JO - Cephalalgia
JF - Cephalalgia
SN - 0800-1952
IS - 3
ER -
ID: 128984080