Increase in vitamin d but not regulatory t cells following ultraviolet b phototherapy of patients with atopic dermatitis

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Increase in vitamin d but not regulatory t cells following ultraviolet b phototherapy of patients with atopic dermatitis. / Simonsen, Stine; Bonefeld, Charlotte Menné; Thyssen, Jacob Pontoppidan; Geisler, Carsten; Skov, Lone.

In: Acta Dermato-Venereologica, Vol. 99, No. 2, 2019, p. 139-145.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Simonsen, S, Bonefeld, CM, Thyssen, JP, Geisler, C & Skov, L 2019, 'Increase in vitamin d but not regulatory t cells following ultraviolet b phototherapy of patients with atopic dermatitis', Acta Dermato-Venereologica, vol. 99, no. 2, pp. 139-145. https://doi.org/10.2340/00015555-3050

APA

Simonsen, S., Bonefeld, C. M., Thyssen, J. P., Geisler, C., & Skov, L. (2019). Increase in vitamin d but not regulatory t cells following ultraviolet b phototherapy of patients with atopic dermatitis. Acta Dermato-Venereologica, 99(2), 139-145. https://doi.org/10.2340/00015555-3050

Vancouver

Simonsen S, Bonefeld CM, Thyssen JP, Geisler C, Skov L. Increase in vitamin d but not regulatory t cells following ultraviolet b phototherapy of patients with atopic dermatitis. Acta Dermato-Venereologica. 2019;99(2):139-145. https://doi.org/10.2340/00015555-3050

Author

Simonsen, Stine ; Bonefeld, Charlotte Menné ; Thyssen, Jacob Pontoppidan ; Geisler, Carsten ; Skov, Lone. / Increase in vitamin d but not regulatory t cells following ultraviolet b phototherapy of patients with atopic dermatitis. In: Acta Dermato-Venereologica. 2019 ; Vol. 99, No. 2. pp. 139-145.

Bibtex

@article{7b8633954de84726a866f2b8822cd2c6,
title = "Increase in vitamin d but not regulatory t cells following ultraviolet b phototherapy of patients with atopic dermatitis",
abstract = "This study investigated serum 25-hydroxyvitamin D (25(OH)D) concentrations and circulating regulatory T cells in patients with atopic dermatitis receiving narrow-band ultraviolet B (nbUVB) phototherapy. Thirty adult patients with atopic dermatitis were included. Blood samples were collected at baseline and at weeks 2 and 4 of nbUVB phototherapy. Skin biopsies were taken at baseline and at week 4. Serum 25(OH) D concentrations increased significantly following nbUVB phototherapy (estimate of change from baseline to week 2: 32.00 nmol/l, confidence interval (CI) 20.48–43.52, p < 0.0001, n = 25; and from baseline to week 4: 50.30 nmol/l, CI 37.28–63.33, p < 0.0001, n = 18). This increase was independent of the filaggrin gene loss-of-function mutation status. Flow cytometry showed no significant change in regulatory T cells or cytokine profiles of T cells in blood. Real-time quantitative PCR showed no change in skin cytokine levels. In conclusion, nbUVB phototherapy was associated with increased serum 25(OH)D concentrations, but not changes in circulating regulatory T cells in patients with atopic dermatitis.",
keywords = "25-hydroxyvitamin D, Atopic dermatitis, Filaggrin, NbUVB phototherapy, Regulatory T cells",
author = "Stine Simonsen and Bonefeld, {Charlotte Menn{\'e}} and Thyssen, {Jacob Pontoppidan} and Carsten Geisler and Lone Skov",
year = "2019",
doi = "10.2340/00015555-3050",
language = "English",
volume = "99",
pages = "139--145",
journal = "Acta Dermato-Venereologica",
issn = "0001-5555",
publisher = "Society for the Publication of Acta Dermato - Venereologica",
number = "2",

}

RIS

TY - JOUR

T1 - Increase in vitamin d but not regulatory t cells following ultraviolet b phototherapy of patients with atopic dermatitis

AU - Simonsen, Stine

AU - Bonefeld, Charlotte Menné

AU - Thyssen, Jacob Pontoppidan

AU - Geisler, Carsten

AU - Skov, Lone

PY - 2019

Y1 - 2019

N2 - This study investigated serum 25-hydroxyvitamin D (25(OH)D) concentrations and circulating regulatory T cells in patients with atopic dermatitis receiving narrow-band ultraviolet B (nbUVB) phototherapy. Thirty adult patients with atopic dermatitis were included. Blood samples were collected at baseline and at weeks 2 and 4 of nbUVB phototherapy. Skin biopsies were taken at baseline and at week 4. Serum 25(OH) D concentrations increased significantly following nbUVB phototherapy (estimate of change from baseline to week 2: 32.00 nmol/l, confidence interval (CI) 20.48–43.52, p < 0.0001, n = 25; and from baseline to week 4: 50.30 nmol/l, CI 37.28–63.33, p < 0.0001, n = 18). This increase was independent of the filaggrin gene loss-of-function mutation status. Flow cytometry showed no significant change in regulatory T cells or cytokine profiles of T cells in blood. Real-time quantitative PCR showed no change in skin cytokine levels. In conclusion, nbUVB phototherapy was associated with increased serum 25(OH)D concentrations, but not changes in circulating regulatory T cells in patients with atopic dermatitis.

AB - This study investigated serum 25-hydroxyvitamin D (25(OH)D) concentrations and circulating regulatory T cells in patients with atopic dermatitis receiving narrow-band ultraviolet B (nbUVB) phototherapy. Thirty adult patients with atopic dermatitis were included. Blood samples were collected at baseline and at weeks 2 and 4 of nbUVB phototherapy. Skin biopsies were taken at baseline and at week 4. Serum 25(OH) D concentrations increased significantly following nbUVB phototherapy (estimate of change from baseline to week 2: 32.00 nmol/l, confidence interval (CI) 20.48–43.52, p < 0.0001, n = 25; and from baseline to week 4: 50.30 nmol/l, CI 37.28–63.33, p < 0.0001, n = 18). This increase was independent of the filaggrin gene loss-of-function mutation status. Flow cytometry showed no significant change in regulatory T cells or cytokine profiles of T cells in blood. Real-time quantitative PCR showed no change in skin cytokine levels. In conclusion, nbUVB phototherapy was associated with increased serum 25(OH)D concentrations, but not changes in circulating regulatory T cells in patients with atopic dermatitis.

KW - 25-hydroxyvitamin D

KW - Atopic dermatitis

KW - Filaggrin

KW - NbUVB phototherapy

KW - Regulatory T cells

U2 - 10.2340/00015555-3050

DO - 10.2340/00015555-3050

M3 - Journal article

C2 - 30250963

AN - SCOPUS:85060957801

VL - 99

SP - 139

EP - 145

JO - Acta Dermato-Venereologica

JF - Acta Dermato-Venereologica

SN - 0001-5555

IS - 2

ER -

ID: 216872777