Incidence, prevalence, and risk of selected ocular disease in adults with atopic dermatitis

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Incidence, prevalence, and risk of selected ocular disease in adults with atopic dermatitis. / Thyssen, Jacob P; Toft, Peter B; Halling-Overgaard, Anne-Sofie; Gislason, Gunnar H; Skov, Lone; Egeberg, Alexander.

In: Journal of the American Academy of Dermatology, Vol. 77, No. 2, 2017, p. 280-286.e1.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Thyssen, JP, Toft, PB, Halling-Overgaard, A-S, Gislason, GH, Skov, L & Egeberg, A 2017, 'Incidence, prevalence, and risk of selected ocular disease in adults with atopic dermatitis', Journal of the American Academy of Dermatology, vol. 77, no. 2, pp. 280-286.e1. https://doi.org/10.1016/j.jaad.2017.03.003

APA

Thyssen, J. P., Toft, P. B., Halling-Overgaard, A-S., Gislason, G. H., Skov, L., & Egeberg, A. (2017). Incidence, prevalence, and risk of selected ocular disease in adults with atopic dermatitis. Journal of the American Academy of Dermatology, 77(2), 280-286.e1. https://doi.org/10.1016/j.jaad.2017.03.003

Vancouver

Thyssen JP, Toft PB, Halling-Overgaard A-S, Gislason GH, Skov L, Egeberg A. Incidence, prevalence, and risk of selected ocular disease in adults with atopic dermatitis. Journal of the American Academy of Dermatology. 2017;77(2):280-286.e1. https://doi.org/10.1016/j.jaad.2017.03.003

Author

Thyssen, Jacob P ; Toft, Peter B ; Halling-Overgaard, Anne-Sofie ; Gislason, Gunnar H ; Skov, Lone ; Egeberg, Alexander. / Incidence, prevalence, and risk of selected ocular disease in adults with atopic dermatitis. In: Journal of the American Academy of Dermatology. 2017 ; Vol. 77, No. 2. pp. 280-286.e1.

Bibtex

@article{91e775106f6b4d4d9751b8b67bcac49a,

title = "Incidence, prevalence, and risk of selected ocular disease in adults with atopic dermatitis",

abstract = "BACKGROUND: Ocular comorbidities are common in atopic dermatitis (AD) as the result of the disease itself or the use of medication. No large-scale epidemiologic data exist on the prevalence of ocular comorbidities in adults with AD.OBJECTIVES: We sought to examine the prevalence and risk of selected ocular comorbidities in adult patients with AD.METHODS: All Danish individuals ≥18 years of age were linked in nationwide registries. Adjusted hazard ratios (HRs) were estimated by means of Cox regression.RESULTS: A total of 5766 and 4272 adults were categorized as having mild and severe AD, respectively. At least 1 prescription of anti-inflammatory ocular agents was claimed in 12.0% and 18.9% of patients with mild and severe AD, respectively. In adjusted analysis, the HR of conjunctivitis was 1.48 (95% confidence interval [CI], 1.15-1.90) for mild AD and 1.95 (95% CI, 1.51-2.51) for severe AD. The HR of keratitis was 1.66 (95% CI, 1.15-2.40) for mild AD and 3.17 (95% CI, 2.31-4.35) for severe AD. For adults with severe AD, the HR for keratoconus was 10.01 (95% CI, 5.02-19.96). AD was associated with {"}cataract only{"} in individuals <50 years of age.LIMITATIONS: A limitation of the study is that observational studies cannot establish causality.CONCLUSIONS: Adults with AD had a significant and disease severity-dependent increased risk of development of conjunctivitis, keratitis, and keratoconus compared with that of the general population.",

keywords = "Adult, Age Factors, Aged, Case-Control Studies, Cataract/epidemiology, Comorbidity, Conjunctivitis/epidemiology, Denmark/epidemiology, Dermatitis, Atopic/epidemiology, Female, Humans, Incidence, Keratitis/epidemiology, Keratoconus/epidemiology, Male, Middle Aged, Prevalence, Proportional Hazards Models, Registries, Risk Assessment, Severity of Illness Index",

author = "Thyssen, {Jacob P} and Toft, {Peter B} and Anne-Sofie Halling-Overgaard and Gislason, {Gunnar H} and Lone Skov and Alexander Egeberg",

year = "2017",

doi = "10.1016/j.jaad.2017.03.003",

language = "English",

volume = "77",

pages = "280--286.e1",

journal = "American Academy of Dermatology. Journal",

issn = "0190-9622",

publisher = "Mosby Inc.",

number = "2",

}

RIS

TY - JOUR

T1 - Incidence, prevalence, and risk of selected ocular disease in adults with atopic dermatitis

AU - Thyssen, Jacob P

AU - Toft, Peter B

AU - Halling-Overgaard, Anne-Sofie

AU - Gislason, Gunnar H

AU - Skov, Lone

AU - Egeberg, Alexander

PY - 2017

Y1 - 2017

N2 - BACKGROUND: Ocular comorbidities are common in atopic dermatitis (AD) as the result of the disease itself or the use of medication. No large-scale epidemiologic data exist on the prevalence of ocular comorbidities in adults with AD.OBJECTIVES: We sought to examine the prevalence and risk of selected ocular comorbidities in adult patients with AD.METHODS: All Danish individuals ≥18 years of age were linked in nationwide registries. Adjusted hazard ratios (HRs) were estimated by means of Cox regression.RESULTS: A total of 5766 and 4272 adults were categorized as having mild and severe AD, respectively. At least 1 prescription of anti-inflammatory ocular agents was claimed in 12.0% and 18.9% of patients with mild and severe AD, respectively. In adjusted analysis, the HR of conjunctivitis was 1.48 (95% confidence interval [CI], 1.15-1.90) for mild AD and 1.95 (95% CI, 1.51-2.51) for severe AD. The HR of keratitis was 1.66 (95% CI, 1.15-2.40) for mild AD and 3.17 (95% CI, 2.31-4.35) for severe AD. For adults with severe AD, the HR for keratoconus was 10.01 (95% CI, 5.02-19.96). AD was associated with "cataract only" in individuals <50 years of age.LIMITATIONS: A limitation of the study is that observational studies cannot establish causality.CONCLUSIONS: Adults with AD had a significant and disease severity-dependent increased risk of development of conjunctivitis, keratitis, and keratoconus compared with that of the general population.

AB - BACKGROUND: Ocular comorbidities are common in atopic dermatitis (AD) as the result of the disease itself or the use of medication. No large-scale epidemiologic data exist on the prevalence of ocular comorbidities in adults with AD.OBJECTIVES: We sought to examine the prevalence and risk of selected ocular comorbidities in adult patients with AD.METHODS: All Danish individuals ≥18 years of age were linked in nationwide registries. Adjusted hazard ratios (HRs) were estimated by means of Cox regression.RESULTS: A total of 5766 and 4272 adults were categorized as having mild and severe AD, respectively. At least 1 prescription of anti-inflammatory ocular agents was claimed in 12.0% and 18.9% of patients with mild and severe AD, respectively. In adjusted analysis, the HR of conjunctivitis was 1.48 (95% confidence interval [CI], 1.15-1.90) for mild AD and 1.95 (95% CI, 1.51-2.51) for severe AD. The HR of keratitis was 1.66 (95% CI, 1.15-2.40) for mild AD and 3.17 (95% CI, 2.31-4.35) for severe AD. For adults with severe AD, the HR for keratoconus was 10.01 (95% CI, 5.02-19.96). AD was associated with "cataract only" in individuals <50 years of age.LIMITATIONS: A limitation of the study is that observational studies cannot establish causality.CONCLUSIONS: Adults with AD had a significant and disease severity-dependent increased risk of development of conjunctivitis, keratitis, and keratoconus compared with that of the general population.

KW - Adult

KW - Age Factors

KW - Aged

KW - Case-Control Studies

KW - Cataract/epidemiology

KW - Comorbidity

KW - Conjunctivitis/epidemiology

KW - Denmark/epidemiology

KW - Dermatitis, Atopic/epidemiology

KW - Female

KW - Humans

KW - Incidence

KW - Keratitis/epidemiology

KW - Keratoconus/epidemiology

KW - Male

KW - Middle Aged

KW - Prevalence

KW - Proportional Hazards Models

KW - Registries

KW - Risk Assessment

KW - Severity of Illness Index

U2 - 10.1016/j.jaad.2017.03.003

DO - 10.1016/j.jaad.2017.03.003

M3 - Journal article

C2 - 28601391

VL - 77

SP - 280-286.e1

JO - American Academy of Dermatology. Journal

JF - American Academy of Dermatology. Journal

SN - 0190-9622

IS - 2

ER -

ID: 197369919