In vitro Superoxide Production by Peripheral Neutrophils from Patients with Inflammatory Bowel Disease

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

In vitro Superoxide Production by Peripheral Neutrophils from Patients with Inflammatory Bowel Disease. / Nielsen, O H; Berild, D; Ahnfelt-Rønne, I.

In: Mediators of Inflammation, Vol. 3, No. 2, 1994, p. 161-4.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nielsen, OH, Berild, D & Ahnfelt-Rønne, I 1994, 'In vitro Superoxide Production by Peripheral Neutrophils from Patients with Inflammatory Bowel Disease', Mediators of Inflammation, vol. 3, no. 2, pp. 161-4. https://doi.org/10.1155/S0962935194000219

APA

Nielsen, O. H., Berild, D., & Ahnfelt-Rønne, I. (1994). In vitro Superoxide Production by Peripheral Neutrophils from Patients with Inflammatory Bowel Disease. Mediators of Inflammation, 3(2), 161-4. https://doi.org/10.1155/S0962935194000219

Vancouver

Nielsen OH, Berild D, Ahnfelt-Rønne I. In vitro Superoxide Production by Peripheral Neutrophils from Patients with Inflammatory Bowel Disease. Mediators of Inflammation. 1994;3(2):161-4. https://doi.org/10.1155/S0962935194000219

Author

Nielsen, O H ; Berild, D ; Ahnfelt-Rønne, I. / In vitro Superoxide Production by Peripheral Neutrophils from Patients with Inflammatory Bowel Disease. In: Mediators of Inflammation. 1994 ; Vol. 3, No. 2. pp. 161-4.

Bibtex

@article{631513350dac40e2b39cc6637e668b3f,
title = "In vitro Superoxide Production by Peripheral Neutrophils from Patients with Inflammatory Bowel Disease",
abstract = "Activated polymorphonuclear leucocytes, which are accumulated in inflammatory lesions of inflammatory bowel disease, produce tissue destructive, oxygen derived free radicals and other inflammatory mediators. The PMN superoxide production elicited by formyl-methionyl-leucyl-phenylalanine or the complement split product 5a were compared in IBD and healthy volunteers. Significantly reduced superoxide production was found in PMNs from patients with Crohn's disease as compared to normal controls, when fMLP or CSa were used as stimulants (p < 0.001 and p < 0.01, respectively), whereas no differences were found when ulcerative colitis patients were compared to normal controls (p > 0.05). The enhanced oxygen derived free radical production previously reported in active IBD, and especially in CD intestinal lesions, may either be due to an accumulation of productive phagocytes or to a change of the inflammatory profile of these cells when migrating into intestinal lesions, possibly due to interaction with other mediators (e.g. adhesion molecules and interleukins).",
author = "Nielsen, {O H} and D Berild and I Ahnfelt-R{\o}nne",
year = "1994",
doi = "10.1155/S0962935194000219",
language = "English",
volume = "3",
pages = "161--4",
journal = "Mediators of Inflammation",
issn = "0962-9351",
publisher = "Hindawi Publishing Corporation",
number = "2",

}

RIS

TY - JOUR

T1 - In vitro Superoxide Production by Peripheral Neutrophils from Patients with Inflammatory Bowel Disease

AU - Nielsen, O H

AU - Berild, D

AU - Ahnfelt-Rønne, I

PY - 1994

Y1 - 1994

N2 - Activated polymorphonuclear leucocytes, which are accumulated in inflammatory lesions of inflammatory bowel disease, produce tissue destructive, oxygen derived free radicals and other inflammatory mediators. The PMN superoxide production elicited by formyl-methionyl-leucyl-phenylalanine or the complement split product 5a were compared in IBD and healthy volunteers. Significantly reduced superoxide production was found in PMNs from patients with Crohn's disease as compared to normal controls, when fMLP or CSa were used as stimulants (p < 0.001 and p < 0.01, respectively), whereas no differences were found when ulcerative colitis patients were compared to normal controls (p > 0.05). The enhanced oxygen derived free radical production previously reported in active IBD, and especially in CD intestinal lesions, may either be due to an accumulation of productive phagocytes or to a change of the inflammatory profile of these cells when migrating into intestinal lesions, possibly due to interaction with other mediators (e.g. adhesion molecules and interleukins).

AB - Activated polymorphonuclear leucocytes, which are accumulated in inflammatory lesions of inflammatory bowel disease, produce tissue destructive, oxygen derived free radicals and other inflammatory mediators. The PMN superoxide production elicited by formyl-methionyl-leucyl-phenylalanine or the complement split product 5a were compared in IBD and healthy volunteers. Significantly reduced superoxide production was found in PMNs from patients with Crohn's disease as compared to normal controls, when fMLP or CSa were used as stimulants (p < 0.001 and p < 0.01, respectively), whereas no differences were found when ulcerative colitis patients were compared to normal controls (p > 0.05). The enhanced oxygen derived free radical production previously reported in active IBD, and especially in CD intestinal lesions, may either be due to an accumulation of productive phagocytes or to a change of the inflammatory profile of these cells when migrating into intestinal lesions, possibly due to interaction with other mediators (e.g. adhesion molecules and interleukins).

U2 - 10.1155/S0962935194000219

DO - 10.1155/S0962935194000219

M3 - Journal article

C2 - 18472936

VL - 3

SP - 161

EP - 164

JO - Mediators of Inflammation

JF - Mediators of Inflammation

SN - 0962-9351

IS - 2

ER -

ID: 218727474