In vitro evaluation of the effects of graphene platelets on glioblastoma multiforme cells
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In vitro evaluation of the effects of graphene platelets on glioblastoma multiforme cells. / Jaworski, Slawomir; Sawosz, Ewa; Grodzik, Marta; Winnicka, Anna; Prasek, Marta; Wierzbicki, Mateusz; Chwalibog, André.
In: International Journal of Nanomedicine (Online), Vol. 8, No. 1, 2013, p. 413-420.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - In vitro evaluation of the effects of graphene platelets on glioblastoma multiforme cells
AU - Jaworski, Slawomir
AU - Sawosz, Ewa
AU - Grodzik, Marta
AU - Winnicka, Anna
AU - Prasek, Marta
AU - Wierzbicki, Mateusz
AU - Chwalibog, André
PY - 2013
Y1 - 2013
N2 - Graphene is a single atom-thick material with exciting potential. It can be used in many fields, from electronics to biomedicine. However, little is known about its toxicity and biocompatibility. Herein, we report a study on the toxicity of graphene platelets (GPs) by examining the influence of GPs on the morphology, mortality, viability, membrane integrity, and type of cell death of U87 and U118 glioma cells. It was found that graphene is toxic to glioma cells, but it activated apoptosis only in the U118 cell line, without inducing necrosis, indicating the potential applicability of GP in anticancer therapy.
AB - Graphene is a single atom-thick material with exciting potential. It can be used in many fields, from electronics to biomedicine. However, little is known about its toxicity and biocompatibility. Herein, we report a study on the toxicity of graphene platelets (GPs) by examining the influence of GPs on the morphology, mortality, viability, membrane integrity, and type of cell death of U87 and U118 glioma cells. It was found that graphene is toxic to glioma cells, but it activated apoptosis only in the U118 cell line, without inducing necrosis, indicating the potential applicability of GP in anticancer therapy.
U2 - 10.2147/IJN.S39456
DO - 10.2147/IJN.S39456
M3 - Journal article
C2 - 23378763
VL - 8
SP - 413
EP - 420
JO - International Journal of Nanomedicine
JF - International Journal of Nanomedicine
SN - 1176-9114
IS - 1
ER -
ID: 44503306