Identification of potent epitopes on hexon capsid protein and their evaluation as vaccine candidates against infections caused by members of Adenoviridae family

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Identification of potent epitopes on hexon capsid protein and their evaluation as vaccine candidates against infections caused by members of Adenoviridae family. / Tufail, Soban; Shah, Majid Ali; Zafar, Maryam; Asif, Tayyab Ali; Shehzad, Aamir; Shah, Muhammad Salahuddin; Habib, Mudasser; Saleemi, Muhammad Kashif; Muddassar, Muhammad; Mirza, Osman; Iqbal, Mazhar; Rahman, Moazur.

In: Vaccine, Vol. 39, No. 27, 2021, p. 3560-3564.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Tufail, S, Shah, MA, Zafar, M, Asif, TA, Shehzad, A, Shah, MS, Habib, M, Saleemi, MK, Muddassar, M, Mirza, O, Iqbal, M & Rahman, M 2021, 'Identification of potent epitopes on hexon capsid protein and their evaluation as vaccine candidates against infections caused by members of Adenoviridae family', Vaccine, vol. 39, no. 27, pp. 3560-3564. https://doi.org/10.1016/j.vaccine.2021.05.023

APA

Tufail, S., Shah, M. A., Zafar, M., Asif, T. A., Shehzad, A., Shah, M. S., Habib, M., Saleemi, M. K., Muddassar, M., Mirza, O., Iqbal, M., & Rahman, M. (2021). Identification of potent epitopes on hexon capsid protein and their evaluation as vaccine candidates against infections caused by members of Adenoviridae family. Vaccine, 39(27), 3560-3564. https://doi.org/10.1016/j.vaccine.2021.05.023

Vancouver

Tufail S, Shah MA, Zafar M, Asif TA, Shehzad A, Shah MS et al. Identification of potent epitopes on hexon capsid protein and their evaluation as vaccine candidates against infections caused by members of Adenoviridae family. Vaccine. 2021;39(27):3560-3564. https://doi.org/10.1016/j.vaccine.2021.05.023

Author

Tufail, Soban ; Shah, Majid Ali ; Zafar, Maryam ; Asif, Tayyab Ali ; Shehzad, Aamir ; Shah, Muhammad Salahuddin ; Habib, Mudasser ; Saleemi, Muhammad Kashif ; Muddassar, Muhammad ; Mirza, Osman ; Iqbal, Mazhar ; Rahman, Moazur. / Identification of potent epitopes on hexon capsid protein and their evaluation as vaccine candidates against infections caused by members of Adenoviridae family. In: Vaccine. 2021 ; Vol. 39, No. 27. pp. 3560-3564.

Bibtex

@article{663b4817f8c7403998e313f9ec307863,

title = "Identification of potent epitopes on hexon capsid protein and their evaluation as vaccine candidates against infections caused by members of Adenoviridae family",

abstract = "Adenoviruses cause economically important diseases in vertebrates. Effective vaccines against adenoviral diseases are currently lacking. Here, we report a highly conserved epitopic region on hexon proteins of adenoviruses that generate a strong immune response when used as a virus-like-particle (VLP) vaccine, produced by inserting the epitopic region into the core protein of hepatitis B virus. For evaluation of its protective efficacy, the epitopic region from a representative adenovirus, fowl adenovirus serotype 4 (FAdV-4), was tested as a VLP vaccine which conferred 90% protection against challenge with a virulent FAdV-4 isolate in chickens. Importantly, such a high level of protection is not achieved when the epitopic region is employed as a part of a subunit vaccine. As the sequence and the structure of the epitopic region are highly conserved in hexon proteins of adenoviruses, the epitopic region could be employed as a promising VLP vaccine candidate against adenoviral diseases, in general.",

author = "Soban Tufail and Shah, {Majid Ali} and Maryam Zafar and Asif, {Tayyab Ali} and Aamir Shehzad and Shah, {Muhammad Salahuddin} and Mudasser Habib and Saleemi, {Muhammad Kashif} and Muhammad Muddassar and Osman Mirza and Mazhar Iqbal and Moazur Rahman",

year = "2021",

doi = "10.1016/j.vaccine.2021.05.023",

language = "English",

volume = "39",

pages = "3560--3564",

journal = "Vaccine",

issn = "0264-410X",

publisher = "Elsevier",

number = "27",

}

RIS

TY - JOUR

T1 - Identification of potent epitopes on hexon capsid protein and their evaluation as vaccine candidates against infections caused by members of Adenoviridae family

AU - Tufail, Soban

AU - Shah, Majid Ali

AU - Zafar, Maryam

AU - Asif, Tayyab Ali

AU - Shehzad, Aamir

AU - Shah, Muhammad Salahuddin

AU - Habib, Mudasser

AU - Saleemi, Muhammad Kashif

AU - Muddassar, Muhammad

AU - Mirza, Osman

AU - Iqbal, Mazhar

AU - Rahman, Moazur

PY - 2021

Y1 - 2021

N2 - Adenoviruses cause economically important diseases in vertebrates. Effective vaccines against adenoviral diseases are currently lacking. Here, we report a highly conserved epitopic region on hexon proteins of adenoviruses that generate a strong immune response when used as a virus-like-particle (VLP) vaccine, produced by inserting the epitopic region into the core protein of hepatitis B virus. For evaluation of its protective efficacy, the epitopic region from a representative adenovirus, fowl adenovirus serotype 4 (FAdV-4), was tested as a VLP vaccine which conferred 90% protection against challenge with a virulent FAdV-4 isolate in chickens. Importantly, such a high level of protection is not achieved when the epitopic region is employed as a part of a subunit vaccine. As the sequence and the structure of the epitopic region are highly conserved in hexon proteins of adenoviruses, the epitopic region could be employed as a promising VLP vaccine candidate against adenoviral diseases, in general.

AB - Adenoviruses cause economically important diseases in vertebrates. Effective vaccines against adenoviral diseases are currently lacking. Here, we report a highly conserved epitopic region on hexon proteins of adenoviruses that generate a strong immune response when used as a virus-like-particle (VLP) vaccine, produced by inserting the epitopic region into the core protein of hepatitis B virus. For evaluation of its protective efficacy, the epitopic region from a representative adenovirus, fowl adenovirus serotype 4 (FAdV-4), was tested as a VLP vaccine which conferred 90% protection against challenge with a virulent FAdV-4 isolate in chickens. Importantly, such a high level of protection is not achieved when the epitopic region is employed as a part of a subunit vaccine. As the sequence and the structure of the epitopic region are highly conserved in hexon proteins of adenoviruses, the epitopic region could be employed as a promising VLP vaccine candidate against adenoviral diseases, in general.

U2 - 10.1016/j.vaccine.2021.05.023

DO - 10.1016/j.vaccine.2021.05.023

M3 - Journal article

C2 - 34030897

VL - 39

SP - 3560

EP - 3564

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 27

ER -

ID: 272115140