Identification of peptide and protein doping related drug compounds confiscated in Denmark between 2007-2013
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Identification of peptide and protein doping related drug compounds confiscated in Denmark between 2007-2013. / Hartvig, Rune Andersen; Holm, Niels Bjerre; Dalsgaard, Petur Weihe; Reitzel, Lotte Ask; Müller, Irene Breum; Linnet, Kristian.
In: Scandinavian Journal of Forensic Science, Vol. 20, No. 2, 12.2014, p. 42-49.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Identification of peptide and protein doping related drug compounds confiscated in Denmark between 2007-2013
AU - Hartvig, Rune Andersen
AU - Holm, Niels Bjerre
AU - Dalsgaard, Petur Weihe
AU - Reitzel, Lotte Ask
AU - Müller, Irene Breum
AU - Linnet, Kristian
PY - 2014/12
Y1 - 2014/12
N2 - We present an overview of protein and peptide compounds confiscated in Denmark from late 2007 till late 2013 together with adescription of a newly developed HRAM-LC-MS method used for identification. As examples of identification, we present data for thepeptides AOD-9604, [D-Ala2, Gln8, Ala15, Leu27]sermorelin and the protein follistatin. It was found that a method with minimum samplepreparation could be implemented for all of the confiscated peptides and the protein somatropin. However, for the protein follistatin itwas necessary to include trypsin digestion in the sample preparation, which considerably increases the overall analysis time.
AB - We present an overview of protein and peptide compounds confiscated in Denmark from late 2007 till late 2013 together with adescription of a newly developed HRAM-LC-MS method used for identification. As examples of identification, we present data for thepeptides AOD-9604, [D-Ala2, Gln8, Ala15, Leu27]sermorelin and the protein follistatin. It was found that a method with minimum samplepreparation could be implemented for all of the confiscated peptides and the protein somatropin. However, for the protein follistatin itwas necessary to include trypsin digestion in the sample preparation, which considerably increases the overall analysis time.
U2 - 10.2478/sjfs-2014-0003
DO - 10.2478/sjfs-2014-0003
M3 - Journal article
VL - 20
SP - 42
EP - 49
JO - Scandinavian Journal of Forensic Science
JF - Scandinavian Journal of Forensic Science
SN - 1503-9552
IS - 2
ER -
ID: 135877064