Hypothalamic perineuronal net assembly is required for sustained diabetes remission induced by fibroblast growth factor 1 in rats

Research output: Contribution to journal › Letter › peer-review

Standard

Hypothalamic perineuronal net assembly is required for sustained diabetes remission induced by fibroblast growth factor 1 in rats. / Alonge, Kimberly M.; Mirzadeh, Zaman; Scarlett, Jarrad M.; Logsdon, Aric F.; Brown, Jenny M.; Cabrales, Elaine; Chan, Christina K.; Kaiyala, Karl J.; Bentsen, Marie A.; Banks, William A.; Guttman, Miklos; Wight, Thomas N.; Morton, Gregory J.; Schwartz, Michael W.

In: Nature Metabolism, Vol. 2, No. 10, 2020, p. 1025-1033.

Research output: Contribution to journal › Letter › peer-review

Harvard

Alonge, KM, Mirzadeh, Z, Scarlett, JM, Logsdon, AF, Brown, JM, Cabrales, E, Chan, CK, Kaiyala, KJ, Bentsen, MA, Banks, WA, Guttman, M, Wight, TN, Morton, GJ & Schwartz, MW 2020, 'Hypothalamic perineuronal net assembly is required for sustained diabetes remission induced by fibroblast growth factor 1 in rats', Nature Metabolism, vol. 2, no. 10, pp. 1025-1033. https://doi.org/10.1038/s42255-020-00275-6

APA

Alonge, K. M., Mirzadeh, Z., Scarlett, J. M., Logsdon, A. F., Brown, J. M., Cabrales, E., Chan, C. K., Kaiyala, K. J., Bentsen, M. A., Banks, W. A., Guttman, M., Wight, T. N., Morton, G. J., & Schwartz, M. W. (2020). Hypothalamic perineuronal net assembly is required for sustained diabetes remission induced by fibroblast growth factor 1 in rats. Nature Metabolism, 2(10), 1025-1033. https://doi.org/10.1038/s42255-020-00275-6

Vancouver

Alonge KM, Mirzadeh Z, Scarlett JM, Logsdon AF, Brown JM, Cabrales E et al. Hypothalamic perineuronal net assembly is required for sustained diabetes remission induced by fibroblast growth factor 1 in rats. Nature Metabolism. 2020;2(10):1025-1033. https://doi.org/10.1038/s42255-020-00275-6

Author

Alonge, Kimberly M. ; Mirzadeh, Zaman ; Scarlett, Jarrad M. ; Logsdon, Aric F. ; Brown, Jenny M. ; Cabrales, Elaine ; Chan, Christina K. ; Kaiyala, Karl J. ; Bentsen, Marie A. ; Banks, William A. ; Guttman, Miklos ; Wight, Thomas N. ; Morton, Gregory J. ; Schwartz, Michael W. / Hypothalamic perineuronal net assembly is required for sustained diabetes remission induced by fibroblast growth factor 1 in rats. In: Nature Metabolism. 2020 ; Vol. 2, No. 10. pp. 1025-1033.

Bibtex

@article{b04b9b269810481c886fc19d72b0cf87,

title = "Hypothalamic perineuronal net assembly is required for sustained diabetes remission induced by fibroblast growth factor 1 in rats",

abstract = "We recently showed that perineuronal nets (PNNs) enmesh glucoregulatory neurons in the arcuate nucleus (Arc) of the mediobasal hypothalamus (MBH)(1), but whether these PNNs play a role in either the pathogenesis of type 2 diabetes (T2D) or its treatment remains unclear. Here we show that PNN abundance within the Arc is markedly reduced in the Zucker diabetic fatty (ZDF) rat model of T2D, compared with normoglycaemic rats, correlating with altered PNN-associated sulfation patterns of chondroitin sulfate glycosaminoglycans in the MBH. Each of these PNN-associated changes is reversed following a single intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1) at a dose that induces sustained diabetes remission in male ZDF rats. Combined with previous work localizing this FGF1 effect to the Arc area(2-4), our finding that enzymatic digestion of Arc PNNs markedly shortens the duration of diabetes remission following icv FGF1 injection in these animals identifies these extracellular matrix structures as previously unrecognized participants in the mechanism underlying diabetes remission induced by the central action of FGF1.",

keywords = "CHONDROITIN SULFATE D, LIQUID-CHROMATOGRAPHY, EXTRACELLULAR-MATRIX, PREFRONTAL CORTEX, AXON-GROWTH, NEURONS, LEPTIN, PLASTICITY, INJECTION, CARTILAGE",

author = "Alonge, {Kimberly M.} and Zaman Mirzadeh and Scarlett, {Jarrad M.} and Logsdon, {Aric F.} and Brown, {Jenny M.} and Elaine Cabrales and Chan, {Christina K.} and Kaiyala, {Karl J.} and Bentsen, {Marie A.} and Banks, {William A.} and Miklos Guttman and Wight, {Thomas N.} and Morton, {Gregory J.} and Schwartz, {Michael W.}",

year = "2020",

doi = "10.1038/s42255-020-00275-6",

language = "English",

volume = "2",

pages = "1025--1033",

journal = "Nature Metabolism",

issn = "2522-5812",

publisher = "Springer",

number = "10",

}

RIS

TY - JOUR

T1 - Hypothalamic perineuronal net assembly is required for sustained diabetes remission induced by fibroblast growth factor 1 in rats

AU - Alonge, Kimberly M.

AU - Mirzadeh, Zaman

AU - Scarlett, Jarrad M.

AU - Logsdon, Aric F.

AU - Brown, Jenny M.

AU - Cabrales, Elaine

AU - Chan, Christina K.

AU - Kaiyala, Karl J.

AU - Bentsen, Marie A.

AU - Banks, William A.

AU - Guttman, Miklos

AU - Wight, Thomas N.

AU - Morton, Gregory J.

AU - Schwartz, Michael W.

PY - 2020

Y1 - 2020

N2 - We recently showed that perineuronal nets (PNNs) enmesh glucoregulatory neurons in the arcuate nucleus (Arc) of the mediobasal hypothalamus (MBH)(1), but whether these PNNs play a role in either the pathogenesis of type 2 diabetes (T2D) or its treatment remains unclear. Here we show that PNN abundance within the Arc is markedly reduced in the Zucker diabetic fatty (ZDF) rat model of T2D, compared with normoglycaemic rats, correlating with altered PNN-associated sulfation patterns of chondroitin sulfate glycosaminoglycans in the MBH. Each of these PNN-associated changes is reversed following a single intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1) at a dose that induces sustained diabetes remission in male ZDF rats. Combined with previous work localizing this FGF1 effect to the Arc area(2-4), our finding that enzymatic digestion of Arc PNNs markedly shortens the duration of diabetes remission following icv FGF1 injection in these animals identifies these extracellular matrix structures as previously unrecognized participants in the mechanism underlying diabetes remission induced by the central action of FGF1.

AB - We recently showed that perineuronal nets (PNNs) enmesh glucoregulatory neurons in the arcuate nucleus (Arc) of the mediobasal hypothalamus (MBH)(1), but whether these PNNs play a role in either the pathogenesis of type 2 diabetes (T2D) or its treatment remains unclear. Here we show that PNN abundance within the Arc is markedly reduced in the Zucker diabetic fatty (ZDF) rat model of T2D, compared with normoglycaemic rats, correlating with altered PNN-associated sulfation patterns of chondroitin sulfate glycosaminoglycans in the MBH. Each of these PNN-associated changes is reversed following a single intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1) at a dose that induces sustained diabetes remission in male ZDF rats. Combined with previous work localizing this FGF1 effect to the Arc area(2-4), our finding that enzymatic digestion of Arc PNNs markedly shortens the duration of diabetes remission following icv FGF1 injection in these animals identifies these extracellular matrix structures as previously unrecognized participants in the mechanism underlying diabetes remission induced by the central action of FGF1.

KW - CHONDROITIN SULFATE D

KW - LIQUID-CHROMATOGRAPHY

KW - EXTRACELLULAR-MATRIX

KW - PREFRONTAL CORTEX

KW - AXON-GROWTH

KW - NEURONS

KW - LEPTIN

KW - PLASTICITY

KW - INJECTION

KW - CARTILAGE

U2 - 10.1038/s42255-020-00275-6

DO - 10.1038/s42255-020-00275-6

M3 - Letter

C2 - 32895577

VL - 2

SP - 1025

EP - 1033

JO - Nature Metabolism

JF - Nature Metabolism

SN - 2522-5812

IS - 10

ER -

ID: 251251815