Hydrate formation during wet granulation studied by spectroscopic methods and multivariate analysis
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Hydrate formation during wet granulation studied by spectroscopic methods and multivariate analysis. / Jørgensen, Anna; Rantanen, Jukka; Karjalainen, Milja; Khriachtchev, Leonid; Räsänen, Eetu; Yliruusi, Jouko.
In: Pharmaceutical Research, Vol. 19, No. 9, 09.2002, p. 1285-91.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Hydrate formation during wet granulation studied by spectroscopic methods and multivariate analysis
AU - Jørgensen, Anna
AU - Rantanen, Jukka
AU - Karjalainen, Milja
AU - Khriachtchev, Leonid
AU - Räsänen, Eetu
AU - Yliruusi, Jouko
PY - 2002/9
Y1 - 2002/9
N2 - PURPOSE: The aim was to follow hydrate formation of two structurally related drugs, theophylline and caffeine, during wet granulation using fast and nondestructive spectroscopic methods.METHODS: Anhydrous theophylline and caffeine were granulated with purified water. Charge-coupled device (CCD) Raman spectroscopy was compared with near-infrared spectroscopy (NIR) in following hydrate formation of drugs during wet granulation (off-line). To perform an at-line process analysis, the effect of water addition was monitored by NIR spectroscopy and principal components analysis (PCA). The changes in the crystal arrangements were verified by using X-ray powder diffraction (XRPD).RESULTS: Hydrate formation of theophylline and caffeine could be followed by CCD Raman spectroscopy. The NIR and Raman spectroscopic results were consistent with each other. NIR revealed the state of water, and Raman spectroscopy gave information related to the drug molecule itself. The XRPD confirmed the spectroscopic results. PCA with three principal components explained 99.9 of the spectral variation in the second derivative NIR spectra.CONCLUSIONS: Both CCD Raman and NIR spectroscopic methods can be applied to monitoring of hydrate formation processes. However, NIR is more suitable for monitoring solid-water interactions.
AB - PURPOSE: The aim was to follow hydrate formation of two structurally related drugs, theophylline and caffeine, during wet granulation using fast and nondestructive spectroscopic methods.METHODS: Anhydrous theophylline and caffeine were granulated with purified water. Charge-coupled device (CCD) Raman spectroscopy was compared with near-infrared spectroscopy (NIR) in following hydrate formation of drugs during wet granulation (off-line). To perform an at-line process analysis, the effect of water addition was monitored by NIR spectroscopy and principal components analysis (PCA). The changes in the crystal arrangements were verified by using X-ray powder diffraction (XRPD).RESULTS: Hydrate formation of theophylline and caffeine could be followed by CCD Raman spectroscopy. The NIR and Raman spectroscopic results were consistent with each other. NIR revealed the state of water, and Raman spectroscopy gave information related to the drug molecule itself. The XRPD confirmed the spectroscopic results. PCA with three principal components explained 99.9 of the spectral variation in the second derivative NIR spectra.CONCLUSIONS: Both CCD Raman and NIR spectroscopic methods can be applied to monitoring of hydrate formation processes. However, NIR is more suitable for monitoring solid-water interactions.
KW - Multivariate Analysis
KW - Spectrum Analysis, Raman
KW - Technology, Pharmaceutical
KW - Wettability
KW - Wetting Agents
M3 - Journal article
C2 - 12403064
VL - 19
SP - 1285
EP - 1291
JO - Pharmaceutical Research
JF - Pharmaceutical Research
SN - 0724-8741
IS - 9
ER -
ID: 140623049