High neonatal blood iron content is associated with the risk of childhood type 1 diabetes mellitus
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High neonatal blood iron content is associated with the risk of childhood type 1 diabetes mellitus. / Kyvsgaard, Julie Nyholm; Overgaard, Anne Julie; Thorsen, Steffen Ullitz; Hansen, Thomas Hesselhøj; Pipper, Christian Bressen; Mortensen, Henrik B.; Pociot, Flemming; Svensson, Jannet.
In: Nutrients, Vol. 9, No. 11, 1221, 2017.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - High neonatal blood iron content is associated with the risk of childhood type 1 diabetes mellitus
AU - Kyvsgaard, Julie Nyholm
AU - Overgaard, Anne Julie
AU - Thorsen, Steffen Ullitz
AU - Hansen, Thomas Hesselhøj
AU - Pipper, Christian Bressen
AU - Mortensen, Henrik B.
AU - Pociot, Flemming
AU - Svensson, Jannet
PY - 2017
Y1 - 2017
N2 - (1) Background: Iron requirement increases during pregnancy and iron supplementation is therefore recommended in many countries. However, excessive iron intake may lead to destruction of pancreatic β-cells. Therefore, we aim to test if higher neonatal iron content in blood is associated with the risk of developing type 1 diabetes mellitus (T1D) in childhood; (2) Methods: A case-control study was conducted, including 199 children diagnosed with T1D before the age of 16 years from 1991 to 2005 and 199 controls matched on date of birth. Information on confounders was available in 181 cases and 154 controls. Iron was measured on a neonatal single dried blood spot sample and was analyzed by laser ablation inductively coupled plasma mass spectrometry. Multivariate logistic regression was used to evaluate if iron content in whole blood was associated with the risk of T1D; (3) Results: A doubling of iron content increased the odds of developing T1D more than two-fold (odds ratio (95% CI), 2.55 (1.04; 6.24)). Iron content increased with maternal age (p = 0.04) and girls had higher content than boys (p = 0.01); (4) Conclusions: Higher neonatal iron content associates to an increased risk of developing T1D before the age of 16 years. Iron supplementation during early childhood needs further investigation, including the causes of high iron in neonates.
AB - (1) Background: Iron requirement increases during pregnancy and iron supplementation is therefore recommended in many countries. However, excessive iron intake may lead to destruction of pancreatic β-cells. Therefore, we aim to test if higher neonatal iron content in blood is associated with the risk of developing type 1 diabetes mellitus (T1D) in childhood; (2) Methods: A case-control study was conducted, including 199 children diagnosed with T1D before the age of 16 years from 1991 to 2005 and 199 controls matched on date of birth. Information on confounders was available in 181 cases and 154 controls. Iron was measured on a neonatal single dried blood spot sample and was analyzed by laser ablation inductively coupled plasma mass spectrometry. Multivariate logistic regression was used to evaluate if iron content in whole blood was associated with the risk of T1D; (3) Results: A doubling of iron content increased the odds of developing T1D more than two-fold (odds ratio (95% CI), 2.55 (1.04; 6.24)). Iron content increased with maternal age (p = 0.04) and girls had higher content than boys (p = 0.01); (4) Conclusions: Higher neonatal iron content associates to an increased risk of developing T1D before the age of 16 years. Iron supplementation during early childhood needs further investigation, including the causes of high iron in neonates.
KW - Journal Article
U2 - 10.3390/nu9111221
DO - 10.3390/nu9111221
M3 - Journal article
C2 - 29113123
VL - 9
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 11
M1 - 1221
ER -
ID: 185617106