Helicobacter pylori infection generates genetic instability in gastric cells

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Helicobacter pylori infection generates genetic instability in gastric cells. / Machado, Ana Manuel Dantas; Figueiredo, Céu; Seruca, Raquel; Rasmussen, Lene Juel.

In: BBA General Subjects, Vol. 1806, No. 1, 2010, p. 58-65.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Machado, AMD, Figueiredo, C, Seruca, R & Rasmussen, LJ 2010, 'Helicobacter pylori infection generates genetic instability in gastric cells', BBA General Subjects, vol. 1806, no. 1, pp. 58-65. https://doi.org/10.1016/j.bbcan.2010.01.007

APA

Machado, A. M. D., Figueiredo, C., Seruca, R., & Rasmussen, L. J. (2010). Helicobacter pylori infection generates genetic instability in gastric cells. BBA General Subjects, 1806(1), 58-65. https://doi.org/10.1016/j.bbcan.2010.01.007

Vancouver

Machado AMD, Figueiredo C, Seruca R, Rasmussen LJ. Helicobacter pylori infection generates genetic instability in gastric cells. BBA General Subjects. 2010;1806(1):58-65. https://doi.org/10.1016/j.bbcan.2010.01.007

Author

Machado, Ana Manuel Dantas ; Figueiredo, Céu ; Seruca, Raquel ; Rasmussen, Lene Juel. / Helicobacter pylori infection generates genetic instability in gastric cells. In: BBA General Subjects. 2010 ; Vol. 1806, No. 1. pp. 58-65.

Bibtex

@article{4b920ca0963511df928f000ea68e967b,

title = "Helicobacter pylori infection generates genetic instability in gastric cells",

abstract = "The discovery that Helicobacter pylori is associated with gastric cancer has led to numerous studies that investigate the mechanisms by which H. pylori induces carcinogenesis. Gastric cancer shows genetic instability both in nuclear and mitochondrial DNA, besides impairment of important DNA repair pathways. As such, this review highlights the consequences of H. pylori infection on the integrity of DNA in the host cells. By down-regulating major DNA repair pathways, H. pylori infection has the potential to generate mutations. In addition, H. pylori infection can induce direct changes on the DNA of the host, such as oxidative damage, methylation, chromosomal instability, microsatellite instability, and mutations. Interestingly, H. pylori infection generates genetic instability in nuclear and mitochondrial DNA. Based on the reviewed literature we conclude that H. pylori infection promotes gastric carcinogenesis by at least three different mechanisms: (1) a combination of increased endogenous DNA damage and decreased repair activities, (2) induction of mutations in the mitochondrial DNA, and (3) generation of a transient mutator phenotype that induces mutations in the nuclear genome.",

author = "Machado, {Ana Manuel Dantas} and C{\'e}u Figueiredo and Raquel Seruca and Rasmussen, {Lene Juel}",

year = "2010",

doi = "10.1016/j.bbcan.2010.01.007",

language = "English",

volume = "1806",

pages = "58--65",

journal = "B B A - General Subjects",

issn = "0304-4165",

publisher = "Elsevier",

number = "1",

}

RIS

TY - JOUR

T1 - Helicobacter pylori infection generates genetic instability in gastric cells

AU - Machado, Ana Manuel Dantas

AU - Figueiredo, Céu

AU - Seruca, Raquel

AU - Rasmussen, Lene Juel

PY - 2010

Y1 - 2010

N2 - The discovery that Helicobacter pylori is associated with gastric cancer has led to numerous studies that investigate the mechanisms by which H. pylori induces carcinogenesis. Gastric cancer shows genetic instability both in nuclear and mitochondrial DNA, besides impairment of important DNA repair pathways. As such, this review highlights the consequences of H. pylori infection on the integrity of DNA in the host cells. By down-regulating major DNA repair pathways, H. pylori infection has the potential to generate mutations. In addition, H. pylori infection can induce direct changes on the DNA of the host, such as oxidative damage, methylation, chromosomal instability, microsatellite instability, and mutations. Interestingly, H. pylori infection generates genetic instability in nuclear and mitochondrial DNA. Based on the reviewed literature we conclude that H. pylori infection promotes gastric carcinogenesis by at least three different mechanisms: (1) a combination of increased endogenous DNA damage and decreased repair activities, (2) induction of mutations in the mitochondrial DNA, and (3) generation of a transient mutator phenotype that induces mutations in the nuclear genome.

AB - The discovery that Helicobacter pylori is associated with gastric cancer has led to numerous studies that investigate the mechanisms by which H. pylori induces carcinogenesis. Gastric cancer shows genetic instability both in nuclear and mitochondrial DNA, besides impairment of important DNA repair pathways. As such, this review highlights the consequences of H. pylori infection on the integrity of DNA in the host cells. By down-regulating major DNA repair pathways, H. pylori infection has the potential to generate mutations. In addition, H. pylori infection can induce direct changes on the DNA of the host, such as oxidative damage, methylation, chromosomal instability, microsatellite instability, and mutations. Interestingly, H. pylori infection generates genetic instability in nuclear and mitochondrial DNA. Based on the reviewed literature we conclude that H. pylori infection promotes gastric carcinogenesis by at least three different mechanisms: (1) a combination of increased endogenous DNA damage and decreased repair activities, (2) induction of mutations in the mitochondrial DNA, and (3) generation of a transient mutator phenotype that induces mutations in the nuclear genome.

U2 - 10.1016/j.bbcan.2010.01.007

DO - 10.1016/j.bbcan.2010.01.007

M3 - Journal article

C2 - 20122996

VL - 1806

SP - 58

EP - 65

JO - B B A - General Subjects

JF - B B A - General Subjects

SN - 0304-4165

IS - 1

ER -

ID: 20990905