Hand-Assisted Laparoscopic Partial Nephrectomy for Large Renal Carcinoma with Succinate Dehydrogenase Deficiency
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Hand-Assisted Laparoscopic Partial Nephrectomy for Large Renal Carcinoma with Succinate Dehydrogenase Deficiency. / Bersang, Ann Buhl; Bube, Sarah; Fode, Mikkel; Azawi, Nessn H.
In: Journal of Endourology Case Reports, Vol. 4, No. 1, 2018, p. 12-14.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Hand-Assisted Laparoscopic Partial Nephrectomy for Large Renal Carcinoma with Succinate Dehydrogenase Deficiency
AU - Bersang, Ann Buhl
AU - Bube, Sarah
AU - Fode, Mikkel
AU - Azawi, Nessn H
PY - 2018
Y1 - 2018
N2 - Background: Germline mutations in succinate dehydrogenase (SDH) are associated with multifocal cancers: pituitary gland tumors, pheochromocytomas, paragangliomas, gastrointestinal stromal tumors, and renal-cell carcinomas (RCCs). SDH-deficient renal-cell carcinoma (SDH-RCC) was first identified in 2004 as an inherited kidney cancer with mutations in the SDH gene. SDH consists of A, B, C, and D units. Mutation in the SDHB gene is the most common mutation in SDH-deficient RCCs. Case Presentation: We report a case of a 51-year-old healthy man diagnosed with SDHB germline mutation and RCCs. Positron emission tomography/computed tomography (PET/CT) showed a 12 cm tumor in the upper pole of the left kidney. A hand-assisted laparoscopic partial nephrectomy was performed and the histopathology of the tumor showed SDH-deficient RCC with clear surgical margins. Six months after the initial presentation, the patient had a slightly impaired renal function and was disease-free on PET/CT. Conclusion: Patients with SDH-deficient RCC are at risk of multifocal kidney tumors and should be offered lifelong follow-up. To preserve the renal function, nephron-sparing surgery is the choice of treatment when feasible, regardless of tumor size.
AB - Background: Germline mutations in succinate dehydrogenase (SDH) are associated with multifocal cancers: pituitary gland tumors, pheochromocytomas, paragangliomas, gastrointestinal stromal tumors, and renal-cell carcinomas (RCCs). SDH-deficient renal-cell carcinoma (SDH-RCC) was first identified in 2004 as an inherited kidney cancer with mutations in the SDH gene. SDH consists of A, B, C, and D units. Mutation in the SDHB gene is the most common mutation in SDH-deficient RCCs. Case Presentation: We report a case of a 51-year-old healthy man diagnosed with SDHB germline mutation and RCCs. Positron emission tomography/computed tomography (PET/CT) showed a 12 cm tumor in the upper pole of the left kidney. A hand-assisted laparoscopic partial nephrectomy was performed and the histopathology of the tumor showed SDH-deficient RCC with clear surgical margins. Six months after the initial presentation, the patient had a slightly impaired renal function and was disease-free on PET/CT. Conclusion: Patients with SDH-deficient RCC are at risk of multifocal kidney tumors and should be offered lifelong follow-up. To preserve the renal function, nephron-sparing surgery is the choice of treatment when feasible, regardless of tumor size.
U2 - 10.1089/cren.2017.0140
DO - 10.1089/cren.2017.0140
M3 - Journal article
C2 - 29450259
VL - 4
SP - 12
EP - 14
JO - Journal of Endourology Case Reports
JF - Journal of Endourology Case Reports
SN - 2379-9889
IS - 1
ER -
ID: 222245157