Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment
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Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment. / Liu, Zhigang; Dai, Xiaoshuang; Zhang, Hongbo; Shi, Renjie; Hui, Yan; Jin, Xin; Zhang, Wentong; Wang, Luanfeng; Wang, Qianxu; Wang, Danna; Wang, Jia; Tan, Xintong; Ren, Bo; Liu, Xiaoning; Zhao, Tong; Wang, Jiamin; Pan, Junru; Yuan, Tian; Chu, Chuanqi; Lan, Lei; Yin, Fei; Cadenas, Enrique; Shi, Lin; Zhao, Shancen; Liu, Xuebo.
In: Nature Communications, Vol. 11, 855, 2020.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment
AU - Liu, Zhigang
AU - Dai, Xiaoshuang
AU - Zhang, Hongbo
AU - Shi, Renjie
AU - Hui, Yan
AU - Jin, Xin
AU - Zhang, Wentong
AU - Wang, Luanfeng
AU - Wang, Qianxu
AU - Wang, Danna
AU - Wang, Jia
AU - Tan, Xintong
AU - Ren, Bo
AU - Liu, Xiaoning
AU - Zhao, Tong
AU - Wang, Jiamin
AU - Pan, Junru
AU - Yuan, Tian
AU - Chu, Chuanqi
AU - Lan, Lei
AU - Yin, Fei
AU - Cadenas, Enrique
AU - Shi, Lin
AU - Zhao, Shancen
AU - Liu, Xuebo
PY - 2020
Y1 - 2020
N2 - Cognitive decline is one of the complications of type 2 diabetes (T2D). Intermittent fasting (IF) is a promising dietary intervention for alleviating T2D symptoms, but its protective effect on diabetes-driven cognitive dysfunction remains elusive. Here, we find that a 28-day IF regimen for diabetic mice improves behavioral impairment via a microbiota-metabolites-brain axis: IF enhances mitochondrial biogenesis and energy metabolism gene expression in hippocampus, re-structures the gut microbiota, and improves microbial metabolites that are related to cognitive function. Moreover, strong connections are observed between IF affected genes, microbiota and metabolites, as assessed by integrative modelling. Removing gut microbiota with antibiotics partly abolishes the neuroprotective effects of IF. Administration of 3-indolepropionic acid, serotonin, short chain fatty acids or tauroursodeoxycholic acid shows a similar effect to IF in terms of improving cognitive function. Together, our study purports the microbiota-metabolites-brain axis as a mechanism that can enable therapeutic strategies against metabolism-implicated cognitive pathophysiologies.
AB - Cognitive decline is one of the complications of type 2 diabetes (T2D). Intermittent fasting (IF) is a promising dietary intervention for alleviating T2D symptoms, but its protective effect on diabetes-driven cognitive dysfunction remains elusive. Here, we find that a 28-day IF regimen for diabetic mice improves behavioral impairment via a microbiota-metabolites-brain axis: IF enhances mitochondrial biogenesis and energy metabolism gene expression in hippocampus, re-structures the gut microbiota, and improves microbial metabolites that are related to cognitive function. Moreover, strong connections are observed between IF affected genes, microbiota and metabolites, as assessed by integrative modelling. Removing gut microbiota with antibiotics partly abolishes the neuroprotective effects of IF. Administration of 3-indolepropionic acid, serotonin, short chain fatty acids or tauroursodeoxycholic acid shows a similar effect to IF in terms of improving cognitive function. Together, our study purports the microbiota-metabolites-brain axis as a mechanism that can enable therapeutic strategies against metabolism-implicated cognitive pathophysiologies.
U2 - 10.1038/s41467-020-14676-4
DO - 10.1038/s41467-020-14676-4
M3 - Journal article
C2 - 32071312
VL - 11
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 855
ER -
ID: 236318395