Genomic and immunohistochemical characterisation of a lacrimal gland oncocytoma and review of literature
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Genomic and immunohistochemical characterisation of a lacrimal gland oncocytoma and review of literature. / Mikkelsen, Lauge Hjorth; Andreasen, Simon; Melchior, Linea Cicilie; Persson, Marta; Andersen, Jeppe Dyrberg; Pereira, Vania; Toft, Peter Bjerre; Morling, Niels; Stenman, Göran; Heegaard, Steffen.
In: Oncology Letters, Vol. 14, No. 4, 10.2017, p. 4176-4182.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Genomic and immunohistochemical characterisation of a lacrimal gland oncocytoma and review of literature
AU - Mikkelsen, Lauge Hjorth
AU - Andreasen, Simon
AU - Melchior, Linea Cicilie
AU - Persson, Marta
AU - Andersen, Jeppe Dyrberg
AU - Pereira, Vania
AU - Toft, Peter Bjerre
AU - Morling, Niels
AU - Stenman, Göran
AU - Heegaard, Steffen
PY - 2017/10
Y1 - 2017/10
N2 - The aim of the present study was to report the genetic and immunohistochemical profile of a rare case of lacrimal gland oncocytoma. A 20-year-old male underwent magnetic resonance imaging (MRI) due to viral encephalitis. Notably, the MRI revealed a multicystic tumor in the left lacrimal gland. A lateral orbitotomy was performed and the tumor was completely excised. Four months following surgery, the patient was free of symptoms. Histopathologically, the tumor was composed of large, eosinophilic and polyhedral cells with small round nuclei. The tumor cells stained strongly for antimitochondrial antibody MU213-UC, cytokeratin (CK) 5/6, CK 7, CK 17, CK 8/18 and CK 19. The final diagnosis was an oncocytoma of the lacrimal gland without any signs of malignancy. Array-based comparative genomic hybridisation demonstrated a gain of one copy of chromosome 8 and loss of one copy of chromosome 22 as the sole genomic imbalances. These chromosomal alterations have not previously been identified in oncocytoma and may be specific to lacrimal gland oncocytoma. Sequencing of the mitochondrial genome demonstrated multiple alterations of the NADH-ubiquinone oxidoreductase chain 5 (ND5) gene involved in mitochondrial oxidative phosphorylation. This may support the notion of a common genetic background of oncocytic lesions in the lacrimal gland and other anatomical sites.
AB - The aim of the present study was to report the genetic and immunohistochemical profile of a rare case of lacrimal gland oncocytoma. A 20-year-old male underwent magnetic resonance imaging (MRI) due to viral encephalitis. Notably, the MRI revealed a multicystic tumor in the left lacrimal gland. A lateral orbitotomy was performed and the tumor was completely excised. Four months following surgery, the patient was free of symptoms. Histopathologically, the tumor was composed of large, eosinophilic and polyhedral cells with small round nuclei. The tumor cells stained strongly for antimitochondrial antibody MU213-UC, cytokeratin (CK) 5/6, CK 7, CK 17, CK 8/18 and CK 19. The final diagnosis was an oncocytoma of the lacrimal gland without any signs of malignancy. Array-based comparative genomic hybridisation demonstrated a gain of one copy of chromosome 8 and loss of one copy of chromosome 22 as the sole genomic imbalances. These chromosomal alterations have not previously been identified in oncocytoma and may be specific to lacrimal gland oncocytoma. Sequencing of the mitochondrial genome demonstrated multiple alterations of the NADH-ubiquinone oxidoreductase chain 5 (ND5) gene involved in mitochondrial oxidative phosphorylation. This may support the notion of a common genetic background of oncocytic lesions in the lacrimal gland and other anatomical sites.
U2 - 10.3892/ol.2017.6713
DO - 10.3892/ol.2017.6713
M3 - Journal article
C2 - 28943925
VL - 14
SP - 4176
EP - 4182
JO - Oncology Letters
JF - Oncology Letters
SN - 1792-1074
IS - 4
ER -
ID: 181450876