TY - JOUR

T1 - Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults

AU - Graff, Mariaelisa

AU - Scott, Robert A.

AU - Justice, Anne E.

AU - Young, Kristin L.

AU - Feitosa, Mary F.

AU - Barata, Llilda

AU - Winkler, Thomas W.

AU - Chu, Audrey Y.

AU - Mahajan, Anubha

AU - Hadley, David

AU - Xue, Luting

AU - Workalemahu, Tsegaselassie

AU - Heard-Costa, Nancy L.

AU - den Hoed, Marcel

AU - Ahluwalia, Tarunveer S.

AU - Qi, Qibin

AU - Ngwa, Julius S.

AU - Renström, Frida

AU - Quaye, Lydia

AU - Eicher, John D.

AU - Hayes, James E.

AU - Cornelis, Marilyn

AU - Kutalik, Zoltan

AU - Lim, Elise

AU - Luan, Jian’an

AU - Huffman, Jennifer E.

AU - Zhang, Weihua

AU - Zhao, Wei

AU - Griffin, Paula J.

AU - Haller, Toomas

AU - Ahmad, Shafqat

AU - Marques-Vidal, Pedro M.

AU - Bien, Stephanie

AU - Yengo, Loic

AU - Teumer, Alexander

AU - Smith, Albert Vernon

AU - Kumari, Meena

AU - Harder, Marie Neergaard

AU - Justesen, Johanne Marie

AU - Kleber, Marcus E

AU - Hollensted, Mette

AU - Aadahl, Mette

AU - Færch, Kristine

AU - Grarup, Niels

AU - Vestergaard, Henrik

AU - Sørensen, Thorkild I.A.

AU - Linneberg, Allan

AU - Hansen, Torben

AU - Pedersen, Oluf

AU - Loos, Ruth J.F.

AU - Kilpeläinen, Tuomas O.

AU - CHARGE Consortium

AU - EPIC-InterAct Consortium

AU - PAGE Consortium

N1 - Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults (PLoS genetics (2017) 13 4 (e1006528)) DOI: 10.1371/journal.pgen.1006972

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.

AB - Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.

UR - http://www.scopus.com/inward/record.url?scp=85018450983&partnerID=8YFLogxK

U2 - 10.1371/journal.pgen.1006528

DO - 10.1371/journal.pgen.1006528

M3 - Journal article

C2 - 28448500

AN - SCOPUS:85018450983

VL - 13

JO - P L o S Genetics

JF - P L o S Genetics

SN - 1553-7390

IS - 4

M1 - e1006528

ER -