Genetic markers of abdominal obesity and weight loss after gastric bypass surgery

Research output: Contribution to journalJournal articlepeer-review

Standard

Genetic markers of abdominal obesity and weight loss after gastric bypass surgery. / Aasbrenn, Martin; Svendstrup, Mathilde; Schnurr, Theresia M.; Hansen, Dorte Lindqvist; Worm, Dorte; Balslev-Harder, Marie; Grarup, Niels; Burgdorf, Kristoffer Sølvsten; Vestergaard, Henrik; Pedersen, Oluf; Angquist, Lars; Fenger, Mogens; Sørensen, Thorkild I. A.; Madsbad, Sten; Hansen, Torben.

In: PLoS ONE, Vol. 16, No. 5, 0252525, 2021.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Aasbrenn, M, Svendstrup, M, Schnurr, TM, Hansen, DL, Worm, D, Balslev-Harder, M, Grarup, N, Burgdorf, KS, Vestergaard, H, Pedersen, O, Angquist, L, Fenger, M, Sørensen, TIA, Madsbad, S & Hansen, T 2021, 'Genetic markers of abdominal obesity and weight loss after gastric bypass surgery', PLoS ONE, vol. 16, no. 5, 0252525. https://doi.org/10.1371/journal.pone.0252525

APA

Aasbrenn, M., Svendstrup, M., Schnurr, T. M., Hansen, D. L., Worm, D., Balslev-Harder, M., Grarup, N., Burgdorf, K. S., Vestergaard, H., Pedersen, O., Angquist, L., Fenger, M., Sørensen, T. I. A., Madsbad, S., & Hansen, T. (2021). Genetic markers of abdominal obesity and weight loss after gastric bypass surgery. PLoS ONE, 16(5), [0252525]. https://doi.org/10.1371/journal.pone.0252525

Vancouver

Aasbrenn M, Svendstrup M, Schnurr TM, Hansen DL, Worm D, Balslev-Harder M et al. Genetic markers of abdominal obesity and weight loss after gastric bypass surgery. PLoS ONE. 2021;16(5). 0252525. https://doi.org/10.1371/journal.pone.0252525

Author

Aasbrenn, Martin ; Svendstrup, Mathilde ; Schnurr, Theresia M. ; Hansen, Dorte Lindqvist ; Worm, Dorte ; Balslev-Harder, Marie ; Grarup, Niels ; Burgdorf, Kristoffer Sølvsten ; Vestergaard, Henrik ; Pedersen, Oluf ; Angquist, Lars ; Fenger, Mogens ; Sørensen, Thorkild I. A. ; Madsbad, Sten ; Hansen, Torben. / Genetic markers of abdominal obesity and weight loss after gastric bypass surgery. In: PLoS ONE. 2021 ; Vol. 16, No. 5.

Bibtex

@article{d4b8484c07bf4f2aa636192faca975e7,
title = "Genetic markers of abdominal obesity and weight loss after gastric bypass surgery",
abstract = "Background Weight loss after bariatric surgery varies widely between individuals, partly due to genetic differences. In addition, genetic determinants of abdominal obesity have been shown to attenuate weight loss after dietary intervention with special attention paid to the rs1358980-T risk allele in the VEGFA locus. Here we aimed to test if updated genetic risk scores (GRSs) for adiposity measures and the rs1358980-T risk allele are linked with weight loss following gastric bypass surgery.Methods Five hundred seventy six patients with morbid obesity underwent Roux-en-Y gastric bypass. A GRS for BMI and a GRS for waist-hip-ratio adjusted for BMI (proxy for abdominal obesity), respectively, were constructed. All patients were genotyped for the rs1358980-T risk allele. Associations between the genetic determinants and weight loss after bariatric surgery were evaluated.Results The GRS for BMI was not associated with weight loss (beta = -2.0 kg/100 risk alleles, 95% CI -7.5 to 3.3, p = 0.45). Even though the GRS for abdominal obesity was associated with an attenuated weight loss response adjusted for age, sex and center (beta = -14.6 kg/100 risk alleles, 95% CI -25.4 to -3.8, p = 0.008), it was not significantly associated with weight loss after adjustment for baseline BMI (beta = -7.9 kg/100 risk alleles, 95% CI -17.5 to 1.6, p = 0.11). Similarly, the rs1358980-T risk allele was not significantly associated with weight loss (beta = -0.8 kg/risk allele, 95% CI -2.2 to 0.6, p = 0.25).Discussion GRSs for adiposity derived from large meta-analyses and the rs1358980-T risk allele in the VEGFA locus did not predict weight loss after gastric bypass surgery. The association between a GRS for abdominal obesity and the response to bariatric surgery may be dependent on the association between the GRS and baseline BMI.",
keywords = "ADIPOSE-TISSUE, BARIATRIC SURGERY, LOSS RESPONSE, RISK SCORE, LINK, FIBROSIS, INFLAMMATION, METABOLISM, HYPOXIA, VARIANT",
author = "Martin Aasbrenn and Mathilde Svendstrup and Schnurr, {Theresia M.} and Hansen, {Dorte Lindqvist} and Dorte Worm and Marie Balslev-Harder and Niels Grarup and Burgdorf, {Kristoffer S{\o}lvsten} and Henrik Vestergaard and Oluf Pedersen and Lars Angquist and Mogens Fenger and S{\o}rensen, {Thorkild I. A.} and Sten Madsbad and Torben Hansen",
year = "2021",
doi = "10.1371/journal.pone.0252525",
language = "English",
volume = "16",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "5",

}

RIS

TY - JOUR

T1 - Genetic markers of abdominal obesity and weight loss after gastric bypass surgery

AU - Aasbrenn, Martin

AU - Svendstrup, Mathilde

AU - Schnurr, Theresia M.

AU - Hansen, Dorte Lindqvist

AU - Worm, Dorte

AU - Balslev-Harder, Marie

AU - Grarup, Niels

AU - Burgdorf, Kristoffer Sølvsten

AU - Vestergaard, Henrik

AU - Pedersen, Oluf

AU - Angquist, Lars

AU - Fenger, Mogens

AU - Sørensen, Thorkild I. A.

AU - Madsbad, Sten

AU - Hansen, Torben

PY - 2021

Y1 - 2021

N2 - Background Weight loss after bariatric surgery varies widely between individuals, partly due to genetic differences. In addition, genetic determinants of abdominal obesity have been shown to attenuate weight loss after dietary intervention with special attention paid to the rs1358980-T risk allele in the VEGFA locus. Here we aimed to test if updated genetic risk scores (GRSs) for adiposity measures and the rs1358980-T risk allele are linked with weight loss following gastric bypass surgery.Methods Five hundred seventy six patients with morbid obesity underwent Roux-en-Y gastric bypass. A GRS for BMI and a GRS for waist-hip-ratio adjusted for BMI (proxy for abdominal obesity), respectively, were constructed. All patients were genotyped for the rs1358980-T risk allele. Associations between the genetic determinants and weight loss after bariatric surgery were evaluated.Results The GRS for BMI was not associated with weight loss (beta = -2.0 kg/100 risk alleles, 95% CI -7.5 to 3.3, p = 0.45). Even though the GRS for abdominal obesity was associated with an attenuated weight loss response adjusted for age, sex and center (beta = -14.6 kg/100 risk alleles, 95% CI -25.4 to -3.8, p = 0.008), it was not significantly associated with weight loss after adjustment for baseline BMI (beta = -7.9 kg/100 risk alleles, 95% CI -17.5 to 1.6, p = 0.11). Similarly, the rs1358980-T risk allele was not significantly associated with weight loss (beta = -0.8 kg/risk allele, 95% CI -2.2 to 0.6, p = 0.25).Discussion GRSs for adiposity derived from large meta-analyses and the rs1358980-T risk allele in the VEGFA locus did not predict weight loss after gastric bypass surgery. The association between a GRS for abdominal obesity and the response to bariatric surgery may be dependent on the association between the GRS and baseline BMI.

AB - Background Weight loss after bariatric surgery varies widely between individuals, partly due to genetic differences. In addition, genetic determinants of abdominal obesity have been shown to attenuate weight loss after dietary intervention with special attention paid to the rs1358980-T risk allele in the VEGFA locus. Here we aimed to test if updated genetic risk scores (GRSs) for adiposity measures and the rs1358980-T risk allele are linked with weight loss following gastric bypass surgery.Methods Five hundred seventy six patients with morbid obesity underwent Roux-en-Y gastric bypass. A GRS for BMI and a GRS for waist-hip-ratio adjusted for BMI (proxy for abdominal obesity), respectively, were constructed. All patients were genotyped for the rs1358980-T risk allele. Associations between the genetic determinants and weight loss after bariatric surgery were evaluated.Results The GRS for BMI was not associated with weight loss (beta = -2.0 kg/100 risk alleles, 95% CI -7.5 to 3.3, p = 0.45). Even though the GRS for abdominal obesity was associated with an attenuated weight loss response adjusted for age, sex and center (beta = -14.6 kg/100 risk alleles, 95% CI -25.4 to -3.8, p = 0.008), it was not significantly associated with weight loss after adjustment for baseline BMI (beta = -7.9 kg/100 risk alleles, 95% CI -17.5 to 1.6, p = 0.11). Similarly, the rs1358980-T risk allele was not significantly associated with weight loss (beta = -0.8 kg/risk allele, 95% CI -2.2 to 0.6, p = 0.25).Discussion GRSs for adiposity derived from large meta-analyses and the rs1358980-T risk allele in the VEGFA locus did not predict weight loss after gastric bypass surgery. The association between a GRS for abdominal obesity and the response to bariatric surgery may be dependent on the association between the GRS and baseline BMI.

KW - ADIPOSE-TISSUE

KW - BARIATRIC SURGERY

KW - LOSS RESPONSE

KW - RISK SCORE

KW - LINK

KW - FIBROSIS

KW - INFLAMMATION

KW - METABOLISM

KW - HYPOXIA

KW - VARIANT

U2 - 10.1371/journal.pone.0252525

DO - 10.1371/journal.pone.0252525

M3 - Journal article

C2 - 34048505

VL - 16

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 5

M1 - 0252525

ER -

ID: 274271303