Genetic diversity of foot-and-mouth disease virus serotype O in Pakistan and Afghanistan, 1997-2009
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Genetic diversity of foot-and-mouth disease virus serotype O in Pakistan and Afghanistan, 1997-2009. / Jamal, Syed M; Ferrari, Giancarlo; Ahmed, Safia; Normann, Preben; Belsham, Graham J.
In: Infection, Genetics and Evolution, Vol. 11, No. 6, 08.2011, p. 1229-38.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Genetic diversity of foot-and-mouth disease virus serotype O in Pakistan and Afghanistan, 1997-2009
AU - Jamal, Syed M
AU - Ferrari, Giancarlo
AU - Ahmed, Safia
AU - Normann, Preben
AU - Belsham, Graham J
N1 - Copyright © 2011 Elsevier B.V. All rights reserved.
PY - 2011/8
Y1 - 2011/8
N2 - Foot-and-mouth disease (FMD) is endemic in Pakistan and Afghanistan; serotypes O, A and Asia-1 of the virus are responsible for the outbreaks in these countries with FMDV type O usually being the most common. In the present study, the nucleotide sequences encoding the FMDV capsid protein VP1 from virus samples were determined. Phylogenetic analysis of the serotype O FMD viruses circulating in Pakistan and Afghanistan between 1997 and 2009 revealed the presence of at least three different lineages within the ME-SA (Middle East South Asia) topotype. The three lineages detected in this study are Pak98, Iran2001 and PanAsia. The PanAsia lineage is currently dominant in the area and is evolving with time as revealed by the appearance of distinct variants e.g. PanAsia-II and a new variant designated here as PanAsia-III. The rates of evolution of the O-PanAsia-II and III sublineages prevalent in the region were found to be 6.65 × 10(-3) (95% CI=5.49-7.80 × 10(-3)) and 7.80 × 10(-3) (95% CI=6.72-8.89 × 10(-3)) substitutions per nucleotide per year, respectively. The present study reveals the presence of multiple (sub-)lineages of FMDV serotype O co-circulating in the region and that significant new variants are frequently emerging.
AB - Foot-and-mouth disease (FMD) is endemic in Pakistan and Afghanistan; serotypes O, A and Asia-1 of the virus are responsible for the outbreaks in these countries with FMDV type O usually being the most common. In the present study, the nucleotide sequences encoding the FMDV capsid protein VP1 from virus samples were determined. Phylogenetic analysis of the serotype O FMD viruses circulating in Pakistan and Afghanistan between 1997 and 2009 revealed the presence of at least three different lineages within the ME-SA (Middle East South Asia) topotype. The three lineages detected in this study are Pak98, Iran2001 and PanAsia. The PanAsia lineage is currently dominant in the area and is evolving with time as revealed by the appearance of distinct variants e.g. PanAsia-II and a new variant designated here as PanAsia-III. The rates of evolution of the O-PanAsia-II and III sublineages prevalent in the region were found to be 6.65 × 10(-3) (95% CI=5.49-7.80 × 10(-3)) and 7.80 × 10(-3) (95% CI=6.72-8.89 × 10(-3)) substitutions per nucleotide per year, respectively. The present study reveals the presence of multiple (sub-)lineages of FMDV serotype O co-circulating in the region and that significant new variants are frequently emerging.
KW - Afghanistan
KW - Animals
KW - Buffaloes
KW - Capsid Proteins/genetics
KW - Cattle
KW - Foot-and-Mouth Disease/virology
KW - Foot-and-Mouth Disease Virus/classification
KW - Genetic Variation
KW - Goats
KW - Pakistan
KW - Phylogeny
KW - Phylogeography
KW - Regression Analysis
KW - Sequence Analysis, DNA
KW - Serotyping
KW - Sheep
U2 - 10.1016/j.meegid.2011.03.006
DO - 10.1016/j.meegid.2011.03.006
M3 - Journal article
C2 - 21419880
VL - 11
SP - 1229
EP - 1238
JO - Infection, Genetics and Evolution
JF - Infection, Genetics and Evolution
SN - 1567-1348
IS - 6
ER -
ID: 257917674