Gastrointestinal function in diabetes is affected regardless of asymptomatic appearance
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Gastrointestinal function in diabetes is affected regardless of asymptomatic appearance. / Wegeberg, Anne Marie; Bertoli, Davide; Ejskjaer, Niels; Brock, Birgitte; Drewes, Asbjørn Mohr; Brock, Christina.
In: Journal of Internal Medicine, Vol. 291, No. 4, 2022, p. 505-512.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Gastrointestinal function in diabetes is affected regardless of asymptomatic appearance
AU - Wegeberg, Anne Marie
AU - Bertoli, Davide
AU - Ejskjaer, Niels
AU - Brock, Birgitte
AU - Drewes, Asbjørn Mohr
AU - Brock, Christina
N1 - Publisher Copyright: © 2021 The Association for the Publication of the Journal of Internal Medicine
PY - 2022
Y1 - 2022
N2 - Background: Gastrointestinal dysmotility may exist without concomitant symptoms. We hypothesize that asymptomatic individuals with diabetes have altered gastrointestinal function associated with age, cardiac vagal tone and glycaemic control. Methods: One hundred fifty-four asymptomatic participants (61 with type 1 diabetes (T1D), 70 type 2 diabetes (T2D) and 23 healthy volunteers (HV)) underwent wireless motility capsule investigation. Transit times, motility indices and pH were retrieved. Age, cardiac vagal tone, glucose and haemoglobin A1c levels were collected. Results: In T1D, prolongation of colonic (p = 0.03) and whole-gut transit times (p = 0.04) were shown. Transpyloric pH rise was decreased in T1D (p = 0.001) and T2D (p = 0.007) and was associated with cardiac vagal tone (p = 0.03) or glucose (p = 0.04) and haemoglobin A1c (p = 0.005). Ileocaecal pH fall was decreased in T2D (p < 0.001). Conclusions: Gastrointestinal function was altered in asymptomatic individuals with diabetes. These findings call for further investigations of gastrointestinal function in order to identify risk factors or even predictors for diabetic enteropathy, particularly when glycaemic control is impaired.
AB - Background: Gastrointestinal dysmotility may exist without concomitant symptoms. We hypothesize that asymptomatic individuals with diabetes have altered gastrointestinal function associated with age, cardiac vagal tone and glycaemic control. Methods: One hundred fifty-four asymptomatic participants (61 with type 1 diabetes (T1D), 70 type 2 diabetes (T2D) and 23 healthy volunteers (HV)) underwent wireless motility capsule investigation. Transit times, motility indices and pH were retrieved. Age, cardiac vagal tone, glucose and haemoglobin A1c levels were collected. Results: In T1D, prolongation of colonic (p = 0.03) and whole-gut transit times (p = 0.04) were shown. Transpyloric pH rise was decreased in T1D (p = 0.001) and T2D (p = 0.007) and was associated with cardiac vagal tone (p = 0.03) or glucose (p = 0.04) and haemoglobin A1c (p = 0.005). Ileocaecal pH fall was decreased in T2D (p < 0.001). Conclusions: Gastrointestinal function was altered in asymptomatic individuals with diabetes. These findings call for further investigations of gastrointestinal function in order to identify risk factors or even predictors for diabetic enteropathy, particularly when glycaemic control is impaired.
KW - diabetes mellitus
KW - digestive
KW - gastrointestinal tract
KW - signs and symptoms
KW - wireless motility capsule
U2 - 10.1111/joim.13416
DO - 10.1111/joim.13416
M3 - Journal article
C2 - 34839554
AN - SCOPUS:85121389163
VL - 291
SP - 505
EP - 512
JO - Journal of Internal Medicine
JF - Journal of Internal Medicine
SN - 0955-7873
IS - 4
ER -
ID: 301343951