Forensic application and genetic diversity of 21 autosomal STR loci in five major population groups of Pakistan

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Forensic application and genetic diversity of 21 autosomal STR loci in five major population groups of Pakistan. / Shan, Muhammad Adnan; Børsting, Claus; Morling, Niels.

In: International Journal of Legal Medicine, Vol. 135, 2021, p. 775-777.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Shan, MA, Børsting, C & Morling, N 2021, 'Forensic application and genetic diversity of 21 autosomal STR loci in five major population groups of Pakistan', International Journal of Legal Medicine, vol. 135, pp. 775-777. https://doi.org/10.1007/s00414-020-02393-y

APA

Shan, M. A., Børsting, C., & Morling, N. (2021). Forensic application and genetic diversity of 21 autosomal STR loci in five major population groups of Pakistan. International Journal of Legal Medicine, 135, 775-777. https://doi.org/10.1007/s00414-020-02393-y

Vancouver

Shan MA, Børsting C, Morling N. Forensic application and genetic diversity of 21 autosomal STR loci in five major population groups of Pakistan. International Journal of Legal Medicine. 2021;135:775-777. https://doi.org/10.1007/s00414-020-02393-y

Author

Shan, Muhammad Adnan ; Børsting, Claus ; Morling, Niels. / Forensic application and genetic diversity of 21 autosomal STR loci in five major population groups of Pakistan. In: International Journal of Legal Medicine. 2021 ; Vol. 135. pp. 775-777.

Bibtex

@article{c72505a630e742f8b20938b0b1e1f4ff,
title = "Forensic application and genetic diversity of 21 autosomal STR loci in five major population groups of Pakistan",
abstract = "Objectives: Investigation of genetic diversity of the 21 autosomal STR loci included in the GlobalFilerTM PCR Amplification Kit in 529 Pakistani individuals belonging to the Punjabi, Pashtun, Sindhi, Saraiki, and Baloch ethnic groups. Population genetic parameters and forensic informative metrics for each group were evaluated. Results: SE33 showed the greatest power of discrimination in all populations studied. The combined match probability ranged from 8.06E−27 (Saraiki) to 1.05E−26 (Baloch), and the combined power of exclusion ranged from 0.99999999902 (Punjabi) to 0.99999999964 (Pashtun). D12S391 in the Baloch population and D2S441 in the Saraiki population showed deviation from Hardy-Weinberg equilibrium. Conclusion: Significant genetic distances were observed between the Punjabi, Pashtun, and Baloch populations. This study supports the utilization of the GlobalFilerTM STR kit for forensic applications in Pakistan.",
keywords = "Autosomal STRs, Forensic genetics, GlobalFiler{\texttrademark}, Pakistan, Population genetics",
author = "Shan, {Muhammad Adnan} and Claus B{\o}rsting and Niels Morling",
year = "2021",
doi = "10.1007/s00414-020-02393-y",
language = "English",
volume = "135",
pages = "775--777",
journal = "International Journal of Legal Medicine (Online)",
issn = "1437-1596",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Forensic application and genetic diversity of 21 autosomal STR loci in five major population groups of Pakistan

AU - Shan, Muhammad Adnan

AU - Børsting, Claus

AU - Morling, Niels

PY - 2021

Y1 - 2021

N2 - Objectives: Investigation of genetic diversity of the 21 autosomal STR loci included in the GlobalFilerTM PCR Amplification Kit in 529 Pakistani individuals belonging to the Punjabi, Pashtun, Sindhi, Saraiki, and Baloch ethnic groups. Population genetic parameters and forensic informative metrics for each group were evaluated. Results: SE33 showed the greatest power of discrimination in all populations studied. The combined match probability ranged from 8.06E−27 (Saraiki) to 1.05E−26 (Baloch), and the combined power of exclusion ranged from 0.99999999902 (Punjabi) to 0.99999999964 (Pashtun). D12S391 in the Baloch population and D2S441 in the Saraiki population showed deviation from Hardy-Weinberg equilibrium. Conclusion: Significant genetic distances were observed between the Punjabi, Pashtun, and Baloch populations. This study supports the utilization of the GlobalFilerTM STR kit for forensic applications in Pakistan.

AB - Objectives: Investigation of genetic diversity of the 21 autosomal STR loci included in the GlobalFilerTM PCR Amplification Kit in 529 Pakistani individuals belonging to the Punjabi, Pashtun, Sindhi, Saraiki, and Baloch ethnic groups. Population genetic parameters and forensic informative metrics for each group were evaluated. Results: SE33 showed the greatest power of discrimination in all populations studied. The combined match probability ranged from 8.06E−27 (Saraiki) to 1.05E−26 (Baloch), and the combined power of exclusion ranged from 0.99999999902 (Punjabi) to 0.99999999964 (Pashtun). D12S391 in the Baloch population and D2S441 in the Saraiki population showed deviation from Hardy-Weinberg equilibrium. Conclusion: Significant genetic distances were observed between the Punjabi, Pashtun, and Baloch populations. This study supports the utilization of the GlobalFilerTM STR kit for forensic applications in Pakistan.

KW - Autosomal STRs

KW - Forensic genetics

KW - GlobalFiler™

KW - Pakistan

KW - Population genetics

UR - http://www.scopus.com/inward/record.url?scp=85091608970&partnerID=8YFLogxK

U2 - 10.1007/s00414-020-02393-y

DO - 10.1007/s00414-020-02393-y

M3 - Journal article

C2 - 32979087

AN - SCOPUS:85091608970

VL - 135

SP - 775

EP - 777

JO - International Journal of Legal Medicine (Online)

JF - International Journal of Legal Medicine (Online)

SN - 1437-1596

ER -

ID: 252110143