Foot-and-mouth disease viruses of the O/ME-SA/Ind-2001e sublineage in Pakistan

Research output: Contribution to journalJournal articleResearchpeer-review

  • Syed M. Jamal
  • Salman Khan
  • Nick J. Knowles
  • Jemma Wadsworth
  • Hayley M. Hicks
  • Valérie Mioulet
  • Abdelghani Bin-Tarif
  • Anna B. Ludi
  • Syed Asad Ali Shah
  • Muhammad Abubakar
  • Shumaila Manzoor
  • Muhammad Afzal
  • Michael Eschbaumer
  • Donald P. King
  • Belsham, Graham John

The presence of foot-and-mouth disease virus (FMDV) of the O/ME-SA/Ind-2001e sublineage within Pakistan was initially detected in two samples collected during 2019. Analysis of further serotype O FMDVs responsible for disease outbreaks in 2019–2020 in the country has now identified the spread of this sublineage to 10 districts within two separate provinces in North-Eastern and North-Western Pakistan. Phylogenetic analysis indicates that these viruses are closely related to those circulating in Bhutan, Nepal and India. The VP1 coding sequences of these viruses from Pakistan belong to three distinct clusters, which may indicate multiple introductions of this virus sublineage, although the routes of introduction are unknown. Vaccine matching studies against O1 Manisa, O 3039 and O TUR/5/2009 support the suitability of existing vaccine strains to control current field outbreaks, but further studies are warranted to monitor the spread and evolution of the O/ME-SA/Ind-2001e sublineage in the region. (145 words).

Original languageEnglish
JournalTransboundary and Emerging Diseases
ISSN1865-1674
DOIs
Publication statusAccepted/In press - 2021

Bibliographical note

Publisher Copyright:
© 2021 Wiley-VCH GmbH

    Research areas

  • antigenicity, aphthovirus, vaccine matching, virus neutralization, virus sequence

ID: 270627437