First-trimester risk calculation for trisomy 13, 18, and 21: comparison of the screening efficiency between 2 locally developed programs and commercial software

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

First-trimester risk calculation for trisomy 13, 18, and 21: comparison of the screening efficiency between 2 locally developed programs and commercial software. / Sørensen, Steen; Momsen, Günther; Sundberg, Karin; Friis-Hansen, Lennart; Jørgensen, Finn Stener.

In: Clinical Chemistry, Vol. 57, No. 7, 2011, p. 1023-31.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sørensen, S, Momsen, G, Sundberg, K, Friis-Hansen, L & Jørgensen, FS 2011, 'First-trimester risk calculation for trisomy 13, 18, and 21: comparison of the screening efficiency between 2 locally developed programs and commercial software', Clinical Chemistry, vol. 57, no. 7, pp. 1023-31. https://doi.org/10.1373/clinchem.2010.161299

APA

Sørensen, S., Momsen, G., Sundberg, K., Friis-Hansen, L., & Jørgensen, F. S. (2011). First-trimester risk calculation for trisomy 13, 18, and 21: comparison of the screening efficiency between 2 locally developed programs and commercial software. Clinical Chemistry, 57(7), 1023-31. https://doi.org/10.1373/clinchem.2010.161299

Vancouver

Sørensen S, Momsen G, Sundberg K, Friis-Hansen L, Jørgensen FS. First-trimester risk calculation for trisomy 13, 18, and 21: comparison of the screening efficiency between 2 locally developed programs and commercial software. Clinical Chemistry. 2011;57(7):1023-31. https://doi.org/10.1373/clinchem.2010.161299

Author

Sørensen, Steen ; Momsen, Günther ; Sundberg, Karin ; Friis-Hansen, Lennart ; Jørgensen, Finn Stener. / First-trimester risk calculation for trisomy 13, 18, and 21: comparison of the screening efficiency between 2 locally developed programs and commercial software. In: Clinical Chemistry. 2011 ; Vol. 57, No. 7. pp. 1023-31.

Bibtex

@article{eb341388210c41b083a1d17bbc767bc7,
title = "First-trimester risk calculation for trisomy 13, 18, and 21: comparison of the screening efficiency between 2 locally developed programs and commercial software",
abstract = "Reliable individual risk calculation for trisomy (T) 13, 18, and 21 in first-trimester screening depends on good estimates of the medians for fetal nuchal translucency thickness (NT), free {\ss}-subunit of human chorionic gonadotropin (hCG{\ss}), and pregnancy-associated plasma protein-A (PAPP-A) in maternal plasma from unaffected pregnancies. Means and SDs of these parameters in unaffected and affected pregnancies are used in the risk calculation program. Unfortunately, our commercial program for risk calculation (Astraia) did not allow use of local medians. We developed 2 alternative risk calculation programs to assess whether the screening efficacies for T13, T18, and T21 could be improved by using our locally estimated medians.",
author = "Steen S{\o}rensen and G{\"u}nther Momsen and Karin Sundberg and Lennart Friis-Hansen and J{\o}rgensen, {Finn Stener}",
year = "2011",
doi = "http://dx.doi.org/10.1373/clinchem.2010.161299",
language = "English",
volume = "57",
pages = "1023--31",
journal = "Clinical Chemistry",
issn = "0009-9147",
publisher = "American Association for Clinical Chemistry, Inc.",
number = "7",

}

RIS

TY - JOUR

T1 - First-trimester risk calculation for trisomy 13, 18, and 21: comparison of the screening efficiency between 2 locally developed programs and commercial software

AU - Sørensen, Steen

AU - Momsen, Günther

AU - Sundberg, Karin

AU - Friis-Hansen, Lennart

AU - Jørgensen, Finn Stener

PY - 2011

Y1 - 2011

N2 - Reliable individual risk calculation for trisomy (T) 13, 18, and 21 in first-trimester screening depends on good estimates of the medians for fetal nuchal translucency thickness (NT), free ß-subunit of human chorionic gonadotropin (hCGß), and pregnancy-associated plasma protein-A (PAPP-A) in maternal plasma from unaffected pregnancies. Means and SDs of these parameters in unaffected and affected pregnancies are used in the risk calculation program. Unfortunately, our commercial program for risk calculation (Astraia) did not allow use of local medians. We developed 2 alternative risk calculation programs to assess whether the screening efficacies for T13, T18, and T21 could be improved by using our locally estimated medians.

AB - Reliable individual risk calculation for trisomy (T) 13, 18, and 21 in first-trimester screening depends on good estimates of the medians for fetal nuchal translucency thickness (NT), free ß-subunit of human chorionic gonadotropin (hCGß), and pregnancy-associated plasma protein-A (PAPP-A) in maternal plasma from unaffected pregnancies. Means and SDs of these parameters in unaffected and affected pregnancies are used in the risk calculation program. Unfortunately, our commercial program for risk calculation (Astraia) did not allow use of local medians. We developed 2 alternative risk calculation programs to assess whether the screening efficacies for T13, T18, and T21 could be improved by using our locally estimated medians.

U2 - http://dx.doi.org/10.1373/clinchem.2010.161299

DO - http://dx.doi.org/10.1373/clinchem.2010.161299

M3 - Journal article

VL - 57

SP - 1023

EP - 1031

JO - Clinical Chemistry

JF - Clinical Chemistry

SN - 0009-9147

IS - 7

ER -

ID: 40167669