Standard
Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants. / Dadaev, Tokhir; Saunders, Edward J.; Newcombe, Paul J.; Anokian, Ezequiel; Leongamornlert, Daniel A.; Brook, Mark N.; Cieza-Borrella, Clara; Mijuskovic, Martina; Wakerell, Sarah; Olama, Ali Amin Al; Schumacher, Fredrick R.; Berndt, Sonja I.; Benlloch, Sara; Ahmed, Mahbubl; Goh, Chee; Sheng, Xin; Zhang, Zhuo; Muir, Kenneth; Govindasami, Koveela; Lophatananon, Artitaya; Stevens, Victoria L.; Gapstur, Susan M.; Carter, Brian D.; Tangen, Catherine M.; Goodman, Phyllis; Thompson, Ian M.; Batra, Jyotsna; Chambers, Suzanne; Moya, Leire; Clements, Judith; Horvath, Lisa; Tilley, Wayne; Risbridger, Gail; Gronberg, Henrik; Aly, Markus; Nordström, Tobias; Pharoah, Paul; Pashayan, Nora; Schleutker, Johanna; Tammela, Teuvo L.J.; Sipeky, Csilla; Auvinen, Anssi; Albanes, Demetrius; Weinstein, Stephanie; Wolk, Alicja; Hakansson, Niclas; West, Catharine; Dunning, Alison M.; Burnet, Neil; Mucci, Lorelei; Giovannucci, Edward; Andriole, Gerald; Cussenot, Olivier; Cancel-Tassin, Géraldine; Koutros, Stella; Freeman, Laura E.Beane; Sorensen, Karina Dalsgaard; Orntoft, Torben Falck; Borre, Michael; Maehle, Lovise; Grindedal, Eli Marie; Neal, David E.; Donovan, Jenny L.; Hamdy, Freddie C.; Martin, Richard M.; Travis, Ruth C.; Key, Tim J.; Hamilton, Robert J.; Fleshner, Neil E.; Finelli, Antonio; Ingles, Sue Ann; Stern, Mariana C.; Rosenstein, Barry; Kerns, Sarah; Ostrer, Harry; Lu, Yong Jie; Zhang, Hong Wei; Feng, Ninghan; Mao, Xueying; Guo, Xin; Wang, Guomin; Sun, Zan; Giles, Graham G.; Southey, Melissa C.; MacInnis, Robert J.; Fitzgerald, Liesel M.; Kibel, Adam S.; Drake, Bettina F.; Vega, Ana; Gómez-Caamaño, Antonio; Fachal, Laura; Szulkin, Robert; Eklund, Martin; Kogevinas, Manolis; Llorca, Javier; Castaño-Vinyals, Gemma; Penney, Kathryn L.; Stampfer, Meir; Park, Jong Y.; Sellers, Thomas A.; Lin, Hui Yi; Stanford, Janet L.; Cybulski, Cezary; Wokolorczyk, Dominika; Lubinski, Jan; Ostrander, Elaine A.; Geybels, Milan S.; Nordestgaard, Børge G.; Nielsen, Sune F.; Weisher, Maren; Bisbjerg, Rasmus; Røder, Martin Andreas; Iversen, Peter; Brenner, Hermann; Cuk, Katarina; Holleczek, Bernd; Maier, Christiane; Luedeke, Manuel; Schnoeller, Thomas; Kim, Jeri; Logothetis, Christopher J.; John, Esther M.; Teixeira, Manuel R.; Paulo, Paula; Cardoso, Marta; Neuhausen, Susan L.; Steele, Linda; Ding, Yuan Chun; De Ruyck, Kim; De Meerleer, Gert; Ost, Piet; Razack, Azad; Lim, Jasmine; Teo, Soo Hwang; Lin, Daniel W.; Newcomb, Lisa F.; Lessel, Davor; Gamulin, Marija; Kulis, Tomislav; Kaneva, Radka; Usmani, Nawaid; Slavov, Chavdar; Mitev, Vanio; Parliament, Matthew; Singhal, Sandeep; Claessens, Frank; Joniau, Steven; Van Den Broeck, Thomas; Larkin, Samantha; Townsend, Paul A.; Aukim-Hastie, Claire; Gago-Dominguez, Manuela; Castelao, Jose Esteban; Martinez, Maria Elena; Roobol, Monique J.; Jenster, Guido; Van Schaik, Ron H.N.; Menegaux, Florence; Truong, Thérèse; Koudou, Yves Akoli; Xu, Jianfeng; Khaw, Kay Tee; Cannon-Albright, Lisa; Pandha, Hardev; Michael, Agnieszka; Kierzek, Andrzej; Thibodeau, Stephen N.; McDonnell, Shannon K.; Schaid, Daniel J.; Lindstrom, Sara; Turman, Constance; Ma, Jing; Hunter, David J.; Riboli, Elio; Siddiq, Afshan; Canzian, Federico; Kolonel, Laurence N.; Le Marchand, Loic; Hoover, Robert N.; Machiela, Mitchell J.; Kraft, Peter; Cook, Margaret; Thwaites, Alison; Guy, Michelle; Whitmore, Ian; Morgan, Angela; Fisher, Cyril; Hazel, Steve; Livni, Naomi; Spurdle, Amanda; Srinivasan, Srilakshmi; Kedda, Mary Anne; Aitken, Joanne; Gardiner, Robert; Hayes, Vanessa; Butler, Lisa; Taylor, Renea; Yeadon, Trina; Eckert, Allison; Saunders, Pamela; Haynes, Anne Maree; Papargiris, Melissa; Kujala, Paula; Talala, Kirsi; Murtola, Teemu; Taari, Kimmo; Dearnaley, David; Barnett, Gill; Bentzen, Søren; Elliott, Rebecca; Ranu, Hardeep; Hicks, Belynda; Vogt, Aurelie; Hutchinson, Amy; Cox, Angela; Davis, Michael; Brown, Paul; George, Anne; Marsden, Gemma; Lane, Athene; Lewis, Sarah J.; Berry, Clare; Kulkarni, Girish S.; Toi, Ants; Evans, Andrew; Zlotta, Alexandre R.; Van Der Kwast, Theodorus H.; Imai, Takashi; Saito, Shiro; Marzec, Jacek; Cao, Guangwen; Lin, Ji; Ling, Jin; Li, Meiling; Zhao, Shan Chao; Ren, Guoping; Yu, Yongwei; Wu, Yudong; Wu, Ji; Zhou, Bo; Zhang, Yangling; Li, Jie; He, Weiyang; Guo, Jianming; Pedersen, John; Hopper, John L.; Milne, Roger; Klim, Aleksandra; Carballo, Ana; Lobato-Busto, Ramón; Peleteiro, Paula; Calvo, Patricia; Aguado, Miguel; Ruiz-Dominguez, José Manuel; Cecchini, Lluís; Mengual, Lourdes; Alcaraz, Antonio; Bustamante, Mariona; Gracia-Lavedan, Esther; Dierssen-Sotos, Trinidad; Gomez-Acebo, Ines; Pow-Sang, Julio; Park, Hyun; Zachariah, Babu; Kluzniak, Wojciech; Kolb, Suzanne; Klarskov, Peter; Stegmaier, Christa; Vogel, Walther; Herkommer, Kathleen; Bohnert, Philipp; Maia, Sofia; Silva, Maria P.; De Langhe, Sofie; Thierens, Hubert; Tan, Meng H.; Ong, Aik T.; Kastelan, Zeljko; Popov, Elenko; Kachakova, Darina; Mitkova, Atanaska; Vlahova, Aleksandrina; Dikov, Tihomir; Christova, Svetlana; Carracedo, Angel; Bangma, Christopher; Schroder, F. H.; Cenee, Sylvie; Tretarre, Brigitte; Rebillard, Xavier; Mulot, Claire; Sanchez, Marie; Adolfsson, Jan; Stattin, Par; Johansson, Jan Erik; Cavalli-Bjoerkman, Carin; Karlsson, Ami; Broms, Michael; Wu, Huihai; Tillmans, Lori; Riska, Shaun; Freedman, Matthew; Wiklund, Fredrik; Chanock, Stephen; Henderson, Brian E.; Easton, Douglas F.; Haiman, Christopher A.; Eeles, Rosalind A.; Conti, David V.; Kote-Jarai, Zsofia.
In:
Nature Communications, Vol. 9, No. 1, 2256, 2018.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Dadaev, T, Saunders, EJ, Newcombe, PJ, Anokian, E, Leongamornlert, DA, Brook, MN, Cieza-Borrella, C, Mijuskovic, M, Wakerell, S, Olama, AAA, Schumacher, FR, Berndt, SI, Benlloch, S, Ahmed, M, Goh, C, Sheng, X, Zhang, Z, Muir, K, Govindasami, K, Lophatananon, A, Stevens, VL, Gapstur, SM, Carter, BD, Tangen, CM, Goodman, P, Thompson, IM, Batra, J, Chambers, S, Moya, L, Clements, J, Horvath, L, Tilley, W, Risbridger, G, Gronberg, H, Aly, M, Nordström, T, Pharoah, P, Pashayan, N, Schleutker, J, Tammela, TLJ, Sipeky, C, Auvinen, A, Albanes, D, Weinstein, S, Wolk, A, Hakansson, N, West, C, Dunning, AM, Burnet, N, Mucci, L, Giovannucci, E, Andriole, G, Cussenot, O, Cancel-Tassin, G, Koutros, S, Freeman, LEB, Sorensen, KD, Orntoft, TF, Borre, M, Maehle, L, Grindedal, EM, Neal, DE, Donovan, JL, Hamdy, FC, Martin, RM, Travis, RC, Key, TJ, Hamilton, RJ, Fleshner, NE, Finelli, A, Ingles, SA, Stern, MC, Rosenstein, B, Kerns, S, Ostrer, H, Lu, YJ, Zhang, HW, Feng, N, Mao, X, Guo, X, Wang, G, Sun, Z, Giles, GG, Southey, MC, MacInnis, RJ, Fitzgerald, LM, Kibel, AS, Drake, BF, Vega, A, Gómez-Caamaño, A, Fachal, L, Szulkin, R, Eklund, M, Kogevinas, M, Llorca, J, Castaño-Vinyals, G, Penney, KL, Stampfer, M, Park, JY, Sellers, TA, Lin, HY, Stanford, JL, Cybulski, C, Wokolorczyk, D, Lubinski, J, Ostrander, EA, Geybels, MS
, Nordestgaard, BG, Nielsen, SF, Weisher, M, Bisbjerg, R
, Røder, MA, Iversen, P, Brenner, H, Cuk, K, Holleczek, B, Maier, C, Luedeke, M, Schnoeller, T, Kim, J, Logothetis, CJ, John, EM, Teixeira, MR, Paulo, P, Cardoso, M, Neuhausen, SL, Steele, L, Ding, YC, De Ruyck, K, De Meerleer, G, Ost, P, Razack, A, Lim, J, Teo, SH, Lin, DW, Newcomb, LF, Lessel, D, Gamulin, M, Kulis, T, Kaneva, R, Usmani, N, Slavov, C, Mitev, V, Parliament, M, Singhal, S, Claessens, F, Joniau, S, Van Den Broeck, T, Larkin, S, Townsend, PA, Aukim-Hastie, C, Gago-Dominguez, M, Castelao, JE, Martinez, ME, Roobol, MJ, Jenster, G, Van Schaik, RHN, Menegaux, F, Truong, T, Koudou, YA, Xu, J, Khaw, KT, Cannon-Albright, L, Pandha, H, Michael, A, Kierzek, A, Thibodeau, SN, McDonnell, SK, Schaid, DJ, Lindstrom, S, Turman, C, Ma, J, Hunter, DJ, Riboli, E, Siddiq, A, Canzian, F, Kolonel, LN, Le Marchand, L, Hoover, RN, Machiela, MJ, Kraft, P, Cook, M, Thwaites, A, Guy, M, Whitmore, I, Morgan, A, Fisher, C, Hazel, S, Livni, N, Spurdle, A, Srinivasan, S, Kedda, MA, Aitken, J, Gardiner, R, Hayes, V, Butler, L, Taylor, R, Yeadon, T, Eckert, A, Saunders, P, Haynes, AM, Papargiris, M, Kujala, P, Talala, K, Murtola, T, Taari, K, Dearnaley, D, Barnett, G, Bentzen, S, Elliott, R, Ranu, H, Hicks, B, Vogt, A, Hutchinson, A, Cox, A, Davis, M, Brown, P, George, A, Marsden, G, Lane, A, Lewis, SJ, Berry, C, Kulkarni, GS, Toi, A, Evans, A, Zlotta, AR, Van Der Kwast, TH, Imai, T, Saito, S, Marzec, J, Cao, G, Lin, J, Ling, J, Li, M, Zhao, SC, Ren, G, Yu, Y, Wu, Y, Wu, J, Zhou, B, Zhang, Y, Li, J, He, W, Guo, J, Pedersen, J, Hopper, JL, Milne, R, Klim, A, Carballo, A, Lobato-Busto, R, Peleteiro, P, Calvo, P, Aguado, M, Ruiz-Dominguez, JM, Cecchini, L, Mengual, L, Alcaraz, A, Bustamante, M, Gracia-Lavedan, E, Dierssen-Sotos, T, Gomez-Acebo, I, Pow-Sang, J, Park, H, Zachariah, B, Kluzniak, W, Kolb, S, Klarskov, P, Stegmaier, C, Vogel, W, Herkommer, K, Bohnert, P, Maia, S, Silva, MP, De Langhe, S, Thierens, H, Tan, MH, Ong, AT, Kastelan, Z, Popov, E, Kachakova, D, Mitkova, A, Vlahova, A, Dikov, T, Christova, S, Carracedo, A, Bangma, C, Schroder, FH, Cenee, S, Tretarre, B, Rebillard, X, Mulot, C, Sanchez, M, Adolfsson, J, Stattin, P, Johansson, JE, Cavalli-Bjoerkman, C, Karlsson, A, Broms, M, Wu, H, Tillmans, L, Riska, S, Freedman, M, Wiklund, F, Chanock, S, Henderson, BE, Easton, DF, Haiman, CA, Eeles, RA, Conti, DV & Kote-Jarai, Z 2018, '
Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants',
Nature Communications, vol. 9, no. 1, 2256.
https://doi.org/10.1038/s41467-018-04109-8APA
Dadaev, T., Saunders, E. J., Newcombe, P. J., Anokian, E., Leongamornlert, D. A., Brook, M. N., Cieza-Borrella, C., Mijuskovic, M., Wakerell, S., Olama, A. A. A., Schumacher, F. R., Berndt, S. I., Benlloch, S., Ahmed, M., Goh, C., Sheng, X., Zhang, Z., Muir, K., Govindasami, K., ... Kote-Jarai, Z. (2018).
Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants.
Nature Communications,
9(1), [2256].
https://doi.org/10.1038/s41467-018-04109-8Vancouver
Dadaev T, Saunders EJ, Newcombe PJ, Anokian E, Leongamornlert DA, Brook MN et al.
Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants.
Nature Communications. 2018;9(1). 2256.
https://doi.org/10.1038/s41467-018-04109-8Author
Dadaev, Tokhir ; Saunders, Edward J. ; Newcombe, Paul J. ; Anokian, Ezequiel ; Leongamornlert, Daniel A. ; Brook, Mark N. ; Cieza-Borrella, Clara ; Mijuskovic, Martina ; Wakerell, Sarah ; Olama, Ali Amin Al ; Schumacher, Fredrick R. ; Berndt, Sonja I. ; Benlloch, Sara ; Ahmed, Mahbubl ; Goh, Chee ; Sheng, Xin ; Zhang, Zhuo ; Muir, Kenneth ; Govindasami, Koveela ; Lophatananon, Artitaya ; Stevens, Victoria L. ; Gapstur, Susan M. ; Carter, Brian D. ; Tangen, Catherine M. ; Goodman, Phyllis ; Thompson, Ian M. ; Batra, Jyotsna ; Chambers, Suzanne ; Moya, Leire ; Clements, Judith ; Horvath, Lisa ; Tilley, Wayne ; Risbridger, Gail ; Gronberg, Henrik ; Aly, Markus ; Nordström, Tobias ; Pharoah, Paul ; Pashayan, Nora ; Schleutker, Johanna ; Tammela, Teuvo L.J. ; Sipeky, Csilla ; Auvinen, Anssi ; Albanes, Demetrius ; Weinstein, Stephanie ; Wolk, Alicja ; Hakansson, Niclas ; West, Catharine ; Dunning, Alison M. ; Burnet, Neil ; Mucci, Lorelei ; Giovannucci, Edward ; Andriole, Gerald ; Cussenot, Olivier ; Cancel-Tassin, Géraldine ; Koutros, Stella ; Freeman, Laura E.Beane ; Sorensen, Karina Dalsgaard ; Orntoft, Torben Falck ; Borre, Michael ; Maehle, Lovise ; Grindedal, Eli Marie ; Neal, David E. ; Donovan, Jenny L. ; Hamdy, Freddie C. ; Martin, Richard M. ; Travis, Ruth C. ; Key, Tim J. ; Hamilton, Robert J. ; Fleshner, Neil E. ; Finelli, Antonio ; Ingles, Sue Ann ; Stern, Mariana C. ; Rosenstein, Barry ; Kerns, Sarah ; Ostrer, Harry ; Lu, Yong Jie ; Zhang, Hong Wei ; Feng, Ninghan ; Mao, Xueying ; Guo, Xin ; Wang, Guomin ; Sun, Zan ; Giles, Graham G. ; Southey, Melissa C. ; MacInnis, Robert J. ; Fitzgerald, Liesel M. ; Kibel, Adam S. ; Drake, Bettina F. ; Vega, Ana ; Gómez-Caamaño, Antonio ; Fachal, Laura ; Szulkin, Robert ; Eklund, Martin ; Kogevinas, Manolis ; Llorca, Javier ; Castaño-Vinyals, Gemma ; Penney, Kathryn L. ; Stampfer, Meir ; Park, Jong Y. ; Sellers, Thomas A. ; Lin, Hui Yi ; Stanford, Janet L. ; Cybulski, Cezary ; Wokolorczyk, Dominika ; Lubinski, Jan ; Ostrander, Elaine A. ; Geybels, Milan S. ; Nordestgaard, Børge G. ; Nielsen, Sune F. ; Weisher, Maren ; Bisbjerg, Rasmus ; Røder, Martin Andreas ; Iversen, Peter ; Brenner, Hermann ; Cuk, Katarina ; Holleczek, Bernd ; Maier, Christiane ; Luedeke, Manuel ; Schnoeller, Thomas ; Kim, Jeri ; Logothetis, Christopher J. ; John, Esther M. ; Teixeira, Manuel R. ; Paulo, Paula ; Cardoso, Marta ; Neuhausen, Susan L. ; Steele, Linda ; Ding, Yuan Chun ; De Ruyck, Kim ; De Meerleer, Gert ; Ost, Piet ; Razack, Azad ; Lim, Jasmine ; Teo, Soo Hwang ; Lin, Daniel W. ; Newcomb, Lisa F. ; Lessel, Davor ; Gamulin, Marija ; Kulis, Tomislav ; Kaneva, Radka ; Usmani, Nawaid ; Slavov, Chavdar ; Mitev, Vanio ; Parliament, Matthew ; Singhal, Sandeep ; Claessens, Frank ; Joniau, Steven ; Van Den Broeck, Thomas ; Larkin, Samantha ; Townsend, Paul A. ; Aukim-Hastie, Claire ; Gago-Dominguez, Manuela ; Castelao, Jose Esteban ; Martinez, Maria Elena ; Roobol, Monique J. ; Jenster, Guido ; Van Schaik, Ron H.N. ; Menegaux, Florence ; Truong, Thérèse ; Koudou, Yves Akoli ; Xu, Jianfeng ; Khaw, Kay Tee ; Cannon-Albright, Lisa ; Pandha, Hardev ; Michael, Agnieszka ; Kierzek, Andrzej ; Thibodeau, Stephen N. ; McDonnell, Shannon K. ; Schaid, Daniel J. ; Lindstrom, Sara ; Turman, Constance ; Ma, Jing ; Hunter, David J. ; Riboli, Elio ; Siddiq, Afshan ; Canzian, Federico ; Kolonel, Laurence N. ; Le Marchand, Loic ; Hoover, Robert N. ; Machiela, Mitchell J. ; Kraft, Peter ; Cook, Margaret ; Thwaites, Alison ; Guy, Michelle ; Whitmore, Ian ; Morgan, Angela ; Fisher, Cyril ; Hazel, Steve ; Livni, Naomi ; Spurdle, Amanda ; Srinivasan, Srilakshmi ; Kedda, Mary Anne ; Aitken, Joanne ; Gardiner, Robert ; Hayes, Vanessa ; Butler, Lisa ; Taylor, Renea ; Yeadon, Trina ; Eckert, Allison ; Saunders, Pamela ; Haynes, Anne Maree ; Papargiris, Melissa ; Kujala, Paula ; Talala, Kirsi ; Murtola, Teemu ; Taari, Kimmo ; Dearnaley, David ; Barnett, Gill ; Bentzen, Søren ; Elliott, Rebecca ; Ranu, Hardeep ; Hicks, Belynda ; Vogt, Aurelie ; Hutchinson, Amy ; Cox, Angela ; Davis, Michael ; Brown, Paul ; George, Anne ; Marsden, Gemma ; Lane, Athene ; Lewis, Sarah J. ; Berry, Clare ; Kulkarni, Girish S. ; Toi, Ants ; Evans, Andrew ; Zlotta, Alexandre R. ; Van Der Kwast, Theodorus H. ; Imai, Takashi ; Saito, Shiro ; Marzec, Jacek ; Cao, Guangwen ; Lin, Ji ; Ling, Jin ; Li, Meiling ; Zhao, Shan Chao ; Ren, Guoping ; Yu, Yongwei ; Wu, Yudong ; Wu, Ji ; Zhou, Bo ; Zhang, Yangling ; Li, Jie ; He, Weiyang ; Guo, Jianming ; Pedersen, John ; Hopper, John L. ; Milne, Roger ; Klim, Aleksandra ; Carballo, Ana ; Lobato-Busto, Ramón ; Peleteiro, Paula ; Calvo, Patricia ; Aguado, Miguel ; Ruiz-Dominguez, José Manuel ; Cecchini, Lluís ; Mengual, Lourdes ; Alcaraz, Antonio ; Bustamante, Mariona ; Gracia-Lavedan, Esther ; Dierssen-Sotos, Trinidad ; Gomez-Acebo, Ines ; Pow-Sang, Julio ; Park, Hyun ; Zachariah, Babu ; Kluzniak, Wojciech ; Kolb, Suzanne ; Klarskov, Peter ; Stegmaier, Christa ; Vogel, Walther ; Herkommer, Kathleen ; Bohnert, Philipp ; Maia, Sofia ; Silva, Maria P. ; De Langhe, Sofie ; Thierens, Hubert ; Tan, Meng H. ; Ong, Aik T. ; Kastelan, Zeljko ; Popov, Elenko ; Kachakova, Darina ; Mitkova, Atanaska ; Vlahova, Aleksandrina ; Dikov, Tihomir ; Christova, Svetlana ; Carracedo, Angel ; Bangma, Christopher ; Schroder, F. H. ; Cenee, Sylvie ; Tretarre, Brigitte ; Rebillard, Xavier ; Mulot, Claire ; Sanchez, Marie ; Adolfsson, Jan ; Stattin, Par ; Johansson, Jan Erik ; Cavalli-Bjoerkman, Carin ; Karlsson, Ami ; Broms, Michael ; Wu, Huihai ; Tillmans, Lori ; Riska, Shaun ; Freedman, Matthew ; Wiklund, Fredrik ; Chanock, Stephen ; Henderson, Brian E. ; Easton, Douglas F. ; Haiman, Christopher A. ; Eeles, Rosalind A. ; Conti, David V. ; Kote-Jarai, Zsofia. / Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants. In: Nature Communications. 2018 ; Vol. 9, No. 1.
Bibtex
@article{7112c57595774a429a54ff7f6156409e,
title = "Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants",
abstract = "Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling.",
author = "Tokhir Dadaev and Saunders, {Edward J.} and Newcombe, {Paul J.} and Ezequiel Anokian and Leongamornlert, {Daniel A.} and Brook, {Mark N.} and Clara Cieza-Borrella and Martina Mijuskovic and Sarah Wakerell and Olama, {Ali Amin Al} and Schumacher, {Fredrick R.} and Berndt, {Sonja I.} and Sara Benlloch and Mahbubl Ahmed and Chee Goh and Xin Sheng and Zhuo Zhang and Kenneth Muir and Koveela Govindasami and Artitaya Lophatananon and Stevens, {Victoria L.} and Gapstur, {Susan M.} and Carter, {Brian D.} and Tangen, {Catherine M.} and Phyllis Goodman and Thompson, {Ian M.} and Jyotsna Batra and Suzanne Chambers and Leire Moya and Judith Clements and Lisa Horvath and Wayne Tilley and Gail Risbridger and Henrik Gronberg and Markus Aly and Tobias Nordstr{\"o}m and Paul Pharoah and Nora Pashayan and Johanna Schleutker and Tammela, {Teuvo L.J.} and Csilla Sipeky and Anssi Auvinen and Demetrius Albanes and Stephanie Weinstein and Alicja Wolk and Niclas Hakansson and Catharine West and Dunning, {Alison M.} and Neil Burnet and Lorelei Mucci and Edward Giovannucci and Gerald Andriole and Olivier Cussenot and G{\'e}raldine Cancel-Tassin and Stella Koutros and Freeman, {Laura E.Beane} and Sorensen, {Karina Dalsgaard} and Orntoft, {Torben Falck} and Michael Borre and Lovise Maehle and Grindedal, {Eli Marie} and Neal, {David E.} and Donovan, {Jenny L.} and Hamdy, {Freddie C.} and Martin, {Richard M.} and Travis, {Ruth C.} and Key, {Tim J.} and Hamilton, {Robert J.} and Fleshner, {Neil E.} and Antonio Finelli and Ingles, {Sue Ann} and Stern, {Mariana C.} and Barry Rosenstein and Sarah Kerns and Harry Ostrer and Lu, {Yong Jie} and Zhang, {Hong Wei} and Ninghan Feng and Xueying Mao and Xin Guo and Guomin Wang and Zan Sun and Giles, {Graham G.} and Southey, {Melissa C.} and MacInnis, {Robert J.} and Fitzgerald, {Liesel M.} and Kibel, {Adam S.} and Drake, {Bettina F.} and Ana Vega and Antonio G{\'o}mez-Caama{\~n}o and Laura Fachal and Robert Szulkin and Martin Eklund and Manolis Kogevinas and Javier Llorca and Gemma Casta{\~n}o-Vinyals and Penney, {Kathryn L.} and Meir Stampfer and Park, {Jong Y.} and Sellers, {Thomas A.} and Lin, {Hui Yi} and Stanford, {Janet L.} and Cezary Cybulski and Dominika Wokolorczyk and Jan Lubinski and Ostrander, {Elaine A.} and Geybels, {Milan S.} and Nordestgaard, {B{\o}rge G.} and Nielsen, {Sune F.} and Maren Weisher and Rasmus Bisbjerg and R{\o}der, {Martin Andreas} and Peter Iversen and Hermann Brenner and Katarina Cuk and Bernd Holleczek and Christiane Maier and Manuel Luedeke and Thomas Schnoeller and Jeri Kim and Logothetis, {Christopher J.} and John, {Esther M.} and Teixeira, {Manuel R.} and Paula Paulo and Marta Cardoso and Neuhausen, {Susan L.} and Linda Steele and Ding, {Yuan Chun} and {De Ruyck}, Kim and {De Meerleer}, Gert and Piet Ost and Azad Razack and Jasmine Lim and Teo, {Soo Hwang} and Lin, {Daniel W.} and Newcomb, {Lisa F.} and Davor Lessel and Marija Gamulin and Tomislav Kulis and Radka Kaneva and Nawaid Usmani and Chavdar Slavov and Vanio Mitev and Matthew Parliament and Sandeep Singhal and Frank Claessens and Steven Joniau and {Van Den Broeck}, Thomas and Samantha Larkin and Townsend, {Paul A.} and Claire Aukim-Hastie and Manuela Gago-Dominguez and Castelao, {Jose Esteban} and Martinez, {Maria Elena} and Roobol, {Monique J.} and Guido Jenster and {Van Schaik}, {Ron H.N.} and Florence Menegaux and Th{\'e}r{\`e}se Truong and Koudou, {Yves Akoli} and Jianfeng Xu and Khaw, {Kay Tee} and Lisa Cannon-Albright and Hardev Pandha and Agnieszka Michael and Andrzej Kierzek and Thibodeau, {Stephen N.} and McDonnell, {Shannon K.} and Schaid, {Daniel J.} and Sara Lindstrom and Constance Turman and Jing Ma and Hunter, {David J.} and Elio Riboli and Afshan Siddiq and Federico Canzian and Kolonel, {Laurence N.} and {Le Marchand}, Loic and Hoover, {Robert N.} and Machiela, {Mitchell J.} and Peter Kraft and Margaret Cook and Alison Thwaites and Michelle Guy and Ian Whitmore and Angela Morgan and Cyril Fisher and Steve Hazel and Naomi Livni and Amanda Spurdle and Srilakshmi Srinivasan and Kedda, {Mary Anne} and Joanne Aitken and Robert Gardiner and Vanessa Hayes and Lisa Butler and Renea Taylor and Trina Yeadon and Allison Eckert and Pamela Saunders and Haynes, {Anne Maree} and Melissa Papargiris and Paula Kujala and Kirsi Talala and Teemu Murtola and Kimmo Taari and David Dearnaley and Gill Barnett and S{\o}ren Bentzen and Rebecca Elliott and Hardeep Ranu and Belynda Hicks and Aurelie Vogt and Amy Hutchinson and Angela Cox and Michael Davis and Paul Brown and Anne George and Gemma Marsden and Athene Lane and Lewis, {Sarah J.} and Clare Berry and Kulkarni, {Girish S.} and Ants Toi and Andrew Evans and Zlotta, {Alexandre R.} and {Van Der Kwast}, {Theodorus H.} and Takashi Imai and Shiro Saito and Jacek Marzec and Guangwen Cao and Ji Lin and Jin Ling and Meiling Li and Zhao, {Shan Chao} and Guoping Ren and Yongwei Yu and Yudong Wu and Ji Wu and Bo Zhou and Yangling Zhang and Jie Li and Weiyang He and Jianming Guo and John Pedersen and Hopper, {John L.} and Roger Milne and Aleksandra Klim and Ana Carballo and Ram{\'o}n Lobato-Busto and Paula Peleteiro and Patricia Calvo and Miguel Aguado and Ruiz-Dominguez, {Jos{\'e} Manuel} and Llu{\'i}s Cecchini and Lourdes Mengual and Antonio Alcaraz and Mariona Bustamante and Esther Gracia-Lavedan and Trinidad Dierssen-Sotos and Ines Gomez-Acebo and Julio Pow-Sang and Hyun Park and Babu Zachariah and Wojciech Kluzniak and Suzanne Kolb and Peter Klarskov and Christa Stegmaier and Walther Vogel and Kathleen Herkommer and Philipp Bohnert and Sofia Maia and Silva, {Maria P.} and {De Langhe}, Sofie and Hubert Thierens and Tan, {Meng H.} and Ong, {Aik T.} and Zeljko Kastelan and Elenko Popov and Darina Kachakova and Atanaska Mitkova and Aleksandrina Vlahova and Tihomir Dikov and Svetlana Christova and Angel Carracedo and Christopher Bangma and Schroder, {F. H.} and Sylvie Cenee and Brigitte Tretarre and Xavier Rebillard and Claire Mulot and Marie Sanchez and Jan Adolfsson and Par Stattin and Johansson, {Jan Erik} and Carin Cavalli-Bjoerkman and Ami Karlsson and Michael Broms and Huihai Wu and Lori Tillmans and Shaun Riska and Matthew Freedman and Fredrik Wiklund and Stephen Chanock and Henderson, {Brian E.} and Easton, {Douglas F.} and Haiman, {Christopher A.} and Eeles, {Rosalind A.} and Conti, {David V.} and Zsofia Kote-Jarai",
year = "2018",
doi = "10.1038/s41467-018-04109-8",
language = "English",
volume = "9",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
number = "1",
}
RIS
TY - JOUR
T1 - Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants
AU - Dadaev, Tokhir
AU - Saunders, Edward J.
AU - Newcombe, Paul J.
AU - Anokian, Ezequiel
AU - Leongamornlert, Daniel A.
AU - Brook, Mark N.
AU - Cieza-Borrella, Clara
AU - Mijuskovic, Martina
AU - Wakerell, Sarah
AU - Olama, Ali Amin Al
AU - Schumacher, Fredrick R.
AU - Berndt, Sonja I.
AU - Benlloch, Sara
AU - Ahmed, Mahbubl
AU - Goh, Chee
AU - Sheng, Xin
AU - Zhang, Zhuo
AU - Muir, Kenneth
AU - Govindasami, Koveela
AU - Lophatananon, Artitaya
AU - Stevens, Victoria L.
AU - Gapstur, Susan M.
AU - Carter, Brian D.
AU - Tangen, Catherine M.
AU - Goodman, Phyllis
AU - Thompson, Ian M.
AU - Batra, Jyotsna
AU - Chambers, Suzanne
AU - Moya, Leire
AU - Clements, Judith
AU - Horvath, Lisa
AU - Tilley, Wayne
AU - Risbridger, Gail
AU - Gronberg, Henrik
AU - Aly, Markus
AU - Nordström, Tobias
AU - Pharoah, Paul
AU - Pashayan, Nora
AU - Schleutker, Johanna
AU - Tammela, Teuvo L.J.
AU - Sipeky, Csilla
AU - Auvinen, Anssi
AU - Albanes, Demetrius
AU - Weinstein, Stephanie
AU - Wolk, Alicja
AU - Hakansson, Niclas
AU - West, Catharine
AU - Dunning, Alison M.
AU - Burnet, Neil
AU - Mucci, Lorelei
AU - Giovannucci, Edward
AU - Andriole, Gerald
AU - Cussenot, Olivier
AU - Cancel-Tassin, Géraldine
AU - Koutros, Stella
AU - Freeman, Laura E.Beane
AU - Sorensen, Karina Dalsgaard
AU - Orntoft, Torben Falck
AU - Borre, Michael
AU - Maehle, Lovise
AU - Grindedal, Eli Marie
AU - Neal, David E.
AU - Donovan, Jenny L.
AU - Hamdy, Freddie C.
AU - Martin, Richard M.
AU - Travis, Ruth C.
AU - Key, Tim J.
AU - Hamilton, Robert J.
AU - Fleshner, Neil E.
AU - Finelli, Antonio
AU - Ingles, Sue Ann
AU - Stern, Mariana C.
AU - Rosenstein, Barry
AU - Kerns, Sarah
AU - Ostrer, Harry
AU - Lu, Yong Jie
AU - Zhang, Hong Wei
AU - Feng, Ninghan
AU - Mao, Xueying
AU - Guo, Xin
AU - Wang, Guomin
AU - Sun, Zan
AU - Giles, Graham G.
AU - Southey, Melissa C.
AU - MacInnis, Robert J.
AU - Fitzgerald, Liesel M.
AU - Kibel, Adam S.
AU - Drake, Bettina F.
AU - Vega, Ana
AU - Gómez-Caamaño, Antonio
AU - Fachal, Laura
AU - Szulkin, Robert
AU - Eklund, Martin
AU - Kogevinas, Manolis
AU - Llorca, Javier
AU - Castaño-Vinyals, Gemma
AU - Penney, Kathryn L.
AU - Stampfer, Meir
AU - Park, Jong Y.
AU - Sellers, Thomas A.
AU - Lin, Hui Yi
AU - Stanford, Janet L.
AU - Cybulski, Cezary
AU - Wokolorczyk, Dominika
AU - Lubinski, Jan
AU - Ostrander, Elaine A.
AU - Geybels, Milan S.
AU - Nordestgaard, Børge G.
AU - Nielsen, Sune F.
AU - Weisher, Maren
AU - Bisbjerg, Rasmus
AU - Røder, Martin Andreas
AU - Iversen, Peter
AU - Brenner, Hermann
AU - Cuk, Katarina
AU - Holleczek, Bernd
AU - Maier, Christiane
AU - Luedeke, Manuel
AU - Schnoeller, Thomas
AU - Kim, Jeri
AU - Logothetis, Christopher J.
AU - John, Esther M.
AU - Teixeira, Manuel R.
AU - Paulo, Paula
AU - Cardoso, Marta
AU - Neuhausen, Susan L.
AU - Steele, Linda
AU - Ding, Yuan Chun
AU - De Ruyck, Kim
AU - De Meerleer, Gert
AU - Ost, Piet
AU - Razack, Azad
AU - Lim, Jasmine
AU - Teo, Soo Hwang
AU - Lin, Daniel W.
AU - Newcomb, Lisa F.
AU - Lessel, Davor
AU - Gamulin, Marija
AU - Kulis, Tomislav
AU - Kaneva, Radka
AU - Usmani, Nawaid
AU - Slavov, Chavdar
AU - Mitev, Vanio
AU - Parliament, Matthew
AU - Singhal, Sandeep
AU - Claessens, Frank
AU - Joniau, Steven
AU - Van Den Broeck, Thomas
AU - Larkin, Samantha
AU - Townsend, Paul A.
AU - Aukim-Hastie, Claire
AU - Gago-Dominguez, Manuela
AU - Castelao, Jose Esteban
AU - Martinez, Maria Elena
AU - Roobol, Monique J.
AU - Jenster, Guido
AU - Van Schaik, Ron H.N.
AU - Menegaux, Florence
AU - Truong, Thérèse
AU - Koudou, Yves Akoli
AU - Xu, Jianfeng
AU - Khaw, Kay Tee
AU - Cannon-Albright, Lisa
AU - Pandha, Hardev
AU - Michael, Agnieszka
AU - Kierzek, Andrzej
AU - Thibodeau, Stephen N.
AU - McDonnell, Shannon K.
AU - Schaid, Daniel J.
AU - Lindstrom, Sara
AU - Turman, Constance
AU - Ma, Jing
AU - Hunter, David J.
AU - Riboli, Elio
AU - Siddiq, Afshan
AU - Canzian, Federico
AU - Kolonel, Laurence N.
AU - Le Marchand, Loic
AU - Hoover, Robert N.
AU - Machiela, Mitchell J.
AU - Kraft, Peter
AU - Cook, Margaret
AU - Thwaites, Alison
AU - Guy, Michelle
AU - Whitmore, Ian
AU - Morgan, Angela
AU - Fisher, Cyril
AU - Hazel, Steve
AU - Livni, Naomi
AU - Spurdle, Amanda
AU - Srinivasan, Srilakshmi
AU - Kedda, Mary Anne
AU - Aitken, Joanne
AU - Gardiner, Robert
AU - Hayes, Vanessa
AU - Butler, Lisa
AU - Taylor, Renea
AU - Yeadon, Trina
AU - Eckert, Allison
AU - Saunders, Pamela
AU - Haynes, Anne Maree
AU - Papargiris, Melissa
AU - Kujala, Paula
AU - Talala, Kirsi
AU - Murtola, Teemu
AU - Taari, Kimmo
AU - Dearnaley, David
AU - Barnett, Gill
AU - Bentzen, Søren
AU - Elliott, Rebecca
AU - Ranu, Hardeep
AU - Hicks, Belynda
AU - Vogt, Aurelie
AU - Hutchinson, Amy
AU - Cox, Angela
AU - Davis, Michael
AU - Brown, Paul
AU - George, Anne
AU - Marsden, Gemma
AU - Lane, Athene
AU - Lewis, Sarah J.
AU - Berry, Clare
AU - Kulkarni, Girish S.
AU - Toi, Ants
AU - Evans, Andrew
AU - Zlotta, Alexandre R.
AU - Van Der Kwast, Theodorus H.
AU - Imai, Takashi
AU - Saito, Shiro
AU - Marzec, Jacek
AU - Cao, Guangwen
AU - Lin, Ji
AU - Ling, Jin
AU - Li, Meiling
AU - Zhao, Shan Chao
AU - Ren, Guoping
AU - Yu, Yongwei
AU - Wu, Yudong
AU - Wu, Ji
AU - Zhou, Bo
AU - Zhang, Yangling
AU - Li, Jie
AU - He, Weiyang
AU - Guo, Jianming
AU - Pedersen, John
AU - Hopper, John L.
AU - Milne, Roger
AU - Klim, Aleksandra
AU - Carballo, Ana
AU - Lobato-Busto, Ramón
AU - Peleteiro, Paula
AU - Calvo, Patricia
AU - Aguado, Miguel
AU - Ruiz-Dominguez, José Manuel
AU - Cecchini, Lluís
AU - Mengual, Lourdes
AU - Alcaraz, Antonio
AU - Bustamante, Mariona
AU - Gracia-Lavedan, Esther
AU - Dierssen-Sotos, Trinidad
AU - Gomez-Acebo, Ines
AU - Pow-Sang, Julio
AU - Park, Hyun
AU - Zachariah, Babu
AU - Kluzniak, Wojciech
AU - Kolb, Suzanne
AU - Klarskov, Peter
AU - Stegmaier, Christa
AU - Vogel, Walther
AU - Herkommer, Kathleen
AU - Bohnert, Philipp
AU - Maia, Sofia
AU - Silva, Maria P.
AU - De Langhe, Sofie
AU - Thierens, Hubert
AU - Tan, Meng H.
AU - Ong, Aik T.
AU - Kastelan, Zeljko
AU - Popov, Elenko
AU - Kachakova, Darina
AU - Mitkova, Atanaska
AU - Vlahova, Aleksandrina
AU - Dikov, Tihomir
AU - Christova, Svetlana
AU - Carracedo, Angel
AU - Bangma, Christopher
AU - Schroder, F. H.
AU - Cenee, Sylvie
AU - Tretarre, Brigitte
AU - Rebillard, Xavier
AU - Mulot, Claire
AU - Sanchez, Marie
AU - Adolfsson, Jan
AU - Stattin, Par
AU - Johansson, Jan Erik
AU - Cavalli-Bjoerkman, Carin
AU - Karlsson, Ami
AU - Broms, Michael
AU - Wu, Huihai
AU - Tillmans, Lori
AU - Riska, Shaun
AU - Freedman, Matthew
AU - Wiklund, Fredrik
AU - Chanock, Stephen
AU - Henderson, Brian E.
AU - Easton, Douglas F.
AU - Haiman, Christopher A.
AU - Eeles, Rosalind A.
AU - Conti, David V.
AU - Kote-Jarai, Zsofia
PY - 2018
Y1 - 2018
N2 - Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling.
AB - Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling.
U2 - 10.1038/s41467-018-04109-8
DO - 10.1038/s41467-018-04109-8
M3 - Journal article
C2 - 29892050
AN - SCOPUS:85048420948
VL - 9
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
IS - 1
M1 - 2256
ER -
