FGF21 Signals to Glutamatergic Neurons in the Ventromedial Hypothalamus to Suppress Carbohydrate Intake

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

FGF21 Signals to Glutamatergic Neurons in the Ventromedial Hypothalamus to Suppress Carbohydrate Intake. / Jensen-Cody, Sharon O.; Flippo, Kyle H.; Claflin, Kristin E.; Yavuz, Yavuz; Sapouckey, Sarah A.; Walters, Grant C.; Usachev, Yuriy M.; Atasoy, Deniz; Gillum, Matthew P.; Potthoff, Matthew J.

In: Cell Metabolism, Vol. 32, No. 2, 2020, p. 273-+.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jensen-Cody, SO, Flippo, KH, Claflin, KE, Yavuz, Y, Sapouckey, SA, Walters, GC, Usachev, YM, Atasoy, D, Gillum, MP & Potthoff, MJ 2020, 'FGF21 Signals to Glutamatergic Neurons in the Ventromedial Hypothalamus to Suppress Carbohydrate Intake', Cell Metabolism, vol. 32, no. 2, pp. 273-+. https://doi.org/10.1016/j.cmet.2020.06.008

APA

Jensen-Cody, S. O., Flippo, K. H., Claflin, K. E., Yavuz, Y., Sapouckey, S. A., Walters, G. C., Usachev, Y. M., Atasoy, D., Gillum, M. P., & Potthoff, M. J. (2020). FGF21 Signals to Glutamatergic Neurons in the Ventromedial Hypothalamus to Suppress Carbohydrate Intake. Cell Metabolism, 32(2), 273-+. https://doi.org/10.1016/j.cmet.2020.06.008

Vancouver

Jensen-Cody SO, Flippo KH, Claflin KE, Yavuz Y, Sapouckey SA, Walters GC et al. FGF21 Signals to Glutamatergic Neurons in the Ventromedial Hypothalamus to Suppress Carbohydrate Intake. Cell Metabolism. 2020;32(2):273-+. https://doi.org/10.1016/j.cmet.2020.06.008

Author

Jensen-Cody, Sharon O. ; Flippo, Kyle H. ; Claflin, Kristin E. ; Yavuz, Yavuz ; Sapouckey, Sarah A. ; Walters, Grant C. ; Usachev, Yuriy M. ; Atasoy, Deniz ; Gillum, Matthew P. ; Potthoff, Matthew J. / FGF21 Signals to Glutamatergic Neurons in the Ventromedial Hypothalamus to Suppress Carbohydrate Intake. In: Cell Metabolism. 2020 ; Vol. 32, No. 2. pp. 273-+.

Bibtex

@article{8680cfd05e3d43239b8467b4dfcc3907,
title = "FGF21 Signals to Glutamatergic Neurons in the Ventromedial Hypothalamus to Suppress Carbohydrate Intake",
abstract = "Fibroblast growth factor 21 (FGF21) is an endocrine hormone produced by the liver that regulates nutrient and metabolic homeostasis. FGF21 production is increased in response to macronutrient imbalance and signals to the brain to suppress sugar intake and sweet-taste preference. However, the central targets mediating these effects have been unclear. Here, we identify FGF21 target cells in the hypothalamus and reveal that FGF21 signaling to glutamatergic neurons is both necessary and sufficient to mediate FGF21-induced sugar suppression and sweet-taste preference. Moreover, we show that FGF21 acts directly in the ventromedial hypothalamus (VMH) to specifically regulate sucrose intake, but not non-nutritive sweet-taste preference, body weight, or energy expenditure. Finally, our data demonstrate that FGF21 affects neuronal activity by increasing activation and excitability of neurons in the VMH. Thus, FGF21 signaling to glutamatergic neurons in the VMH is an important component of the neurocircuitry that functions to regulate sucrose intake.",
keywords = "GLUCOSE-SENSING NEURONS, BODY-WEIGHT, FOOD-INTAKE, REGULATES METABOLISM, GABAERGIC NEURONS, BETA-KLOTHO, BRAIN, TASTE, DOPAMINE, PATHWAYS",
author = "Jensen-Cody, {Sharon O.} and Flippo, {Kyle H.} and Claflin, {Kristin E.} and Yavuz Yavuz and Sapouckey, {Sarah A.} and Walters, {Grant C.} and Usachev, {Yuriy M.} and Deniz Atasoy and Gillum, {Matthew P.} and Potthoff, {Matthew J.}",
year = "2020",
doi = "10.1016/j.cmet.2020.06.008",
language = "English",
volume = "32",
pages = "273--+",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "2",

}

RIS

TY - JOUR

T1 - FGF21 Signals to Glutamatergic Neurons in the Ventromedial Hypothalamus to Suppress Carbohydrate Intake

AU - Jensen-Cody, Sharon O.

AU - Flippo, Kyle H.

AU - Claflin, Kristin E.

AU - Yavuz, Yavuz

AU - Sapouckey, Sarah A.

AU - Walters, Grant C.

AU - Usachev, Yuriy M.

AU - Atasoy, Deniz

AU - Gillum, Matthew P.

AU - Potthoff, Matthew J.

PY - 2020

Y1 - 2020

N2 - Fibroblast growth factor 21 (FGF21) is an endocrine hormone produced by the liver that regulates nutrient and metabolic homeostasis. FGF21 production is increased in response to macronutrient imbalance and signals to the brain to suppress sugar intake and sweet-taste preference. However, the central targets mediating these effects have been unclear. Here, we identify FGF21 target cells in the hypothalamus and reveal that FGF21 signaling to glutamatergic neurons is both necessary and sufficient to mediate FGF21-induced sugar suppression and sweet-taste preference. Moreover, we show that FGF21 acts directly in the ventromedial hypothalamus (VMH) to specifically regulate sucrose intake, but not non-nutritive sweet-taste preference, body weight, or energy expenditure. Finally, our data demonstrate that FGF21 affects neuronal activity by increasing activation and excitability of neurons in the VMH. Thus, FGF21 signaling to glutamatergic neurons in the VMH is an important component of the neurocircuitry that functions to regulate sucrose intake.

AB - Fibroblast growth factor 21 (FGF21) is an endocrine hormone produced by the liver that regulates nutrient and metabolic homeostasis. FGF21 production is increased in response to macronutrient imbalance and signals to the brain to suppress sugar intake and sweet-taste preference. However, the central targets mediating these effects have been unclear. Here, we identify FGF21 target cells in the hypothalamus and reveal that FGF21 signaling to glutamatergic neurons is both necessary and sufficient to mediate FGF21-induced sugar suppression and sweet-taste preference. Moreover, we show that FGF21 acts directly in the ventromedial hypothalamus (VMH) to specifically regulate sucrose intake, but not non-nutritive sweet-taste preference, body weight, or energy expenditure. Finally, our data demonstrate that FGF21 affects neuronal activity by increasing activation and excitability of neurons in the VMH. Thus, FGF21 signaling to glutamatergic neurons in the VMH is an important component of the neurocircuitry that functions to regulate sucrose intake.

KW - GLUCOSE-SENSING NEURONS

KW - BODY-WEIGHT

KW - FOOD-INTAKE

KW - REGULATES METABOLISM

KW - GABAERGIC NEURONS

KW - BETA-KLOTHO

KW - BRAIN

KW - TASTE

KW - DOPAMINE

KW - PATHWAYS

U2 - 10.1016/j.cmet.2020.06.008

DO - 10.1016/j.cmet.2020.06.008

M3 - Journal article

C2 - 32640184

VL - 32

SP - 273-+

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 2

ER -

ID: 250118243