Extracellular circulating viral microRNAs: Current knowledge and perspectives
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Extracellular circulating viral microRNAs : Current knowledge and perspectives. / Laganà, Alessandro; Russo, Francesco; Veneziano, Dario; Bella, Sebastiano Di; Giugno, Rosalba; Pulvirenti, Alfredo; Croce, Carlo M.; Ferro, Alfredo.
In: Frontiers in Genetics, Vol. 4, Article 120, 2013.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Extracellular circulating viral microRNAs
T2 - Current knowledge and perspectives
AU - Laganà, Alessandro
AU - Russo, Francesco
AU - Veneziano, Dario
AU - Bella, Sebastiano Di
AU - Giugno, Rosalba
AU - Pulvirenti, Alfredo
AU - Croce, Carlo M.
AU - Ferro, Alfredo
PY - 2013
Y1 - 2013
N2 - MicroRNAs (miRNAs) are small non-coding RNAs responsible of post-transcriptional regulation of gene expression through interaction with messenger RNAs (mRNAs). They are involved in important biological processes and are often dysregulated in a variety of diseases, including cancer and infections. Viruses also encode their own sets of miRNAs, which they use to control the expression of either the host's genes and/or their own. In the past few years evidence of the presence of cellular miRNAs in extracellular human body fluids such as serum, plasma, saliva, and urine has accumulated. They have been found either cofractionate with the Argonaute2 protein or in membrane-bound vesicles such as exosomes. Although little is known about the role of circulating miRNAs, it has been demonstrated that miRNAs secreted by virus-infected cells are transferred to and act in uninfected recipient cells. In this work we summarize the current knowledge on viral circulating miRNAs and provide a few examples of computational prediction of their function.
AB - MicroRNAs (miRNAs) are small non-coding RNAs responsible of post-transcriptional regulation of gene expression through interaction with messenger RNAs (mRNAs). They are involved in important biological processes and are often dysregulated in a variety of diseases, including cancer and infections. Viruses also encode their own sets of miRNAs, which they use to control the expression of either the host's genes and/or their own. In the past few years evidence of the presence of cellular miRNAs in extracellular human body fluids such as serum, plasma, saliva, and urine has accumulated. They have been found either cofractionate with the Argonaute2 protein or in membrane-bound vesicles such as exosomes. Although little is known about the role of circulating miRNAs, it has been demonstrated that miRNAs secreted by virus-infected cells are transferred to and act in uninfected recipient cells. In this work we summarize the current knowledge on viral circulating miRNAs and provide a few examples of computational prediction of their function.
KW - Body fluids
KW - Circulating microRNA
KW - Exosomes
KW - microRNA
KW - Vesicules
KW - Viruses
U2 - 10.3389/fgene.2013.00120
DO - 10.3389/fgene.2013.00120
M3 - Review
AN - SCOPUS:84883496491
VL - 4
JO - Frontiers in Genetics
JF - Frontiers in Genetics
SN - 1664-8021
M1 - Article 120
ER -
ID: 209066186