Exposure to potential drug interactions in primary health care
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Exposure to potential drug interactions in primary health care. / Bjerrum, Lars; Andersen, Morten; Petersen, Gert; Kragstrup, Jakob.
In: Scandinavian Journal of Primary Health Care, Vol. 21, No. 3, 09.2003, p. 153-8.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Exposure to potential drug interactions in primary health care
AU - Bjerrum, Lars
AU - Andersen, Morten
AU - Petersen, Gert
AU - Kragstrup, Jakob
PY - 2003/9
Y1 - 2003/9
N2 - OBJECTIVE: To analyse the prevalence of potential drug interactions, and to identify patients particularly prone to drug interaction.DESIGN: Database study (Odense University Pharmacoepidemiologic Database).SETTING: Individuals exposed to polypharmacy in 1999 were examined for potential drug interactions.SUBJECTS: Inhabitants of the County of Funen (n = 471 732).MAIN OUTCOME MEASURES: Prevalence of potential drug interactions.RESULTS: One-third of the population were exposed to polypharmacy and among these 15% were exposed to drugs carrying a risk of harmful interaction. Among the elderly with polypharmacy, 25% aged 60-79 years and 36% over 80 years received drugs carrying the risk of interaction. Among individuals exposed to potential drug interaction, 62% were exposed only to one drug interaction and 38% to two or more different drug interactions. The drugs accounting for the highest number of potential interactions were diuretics, NSAIDs, ACE-inhibitors, digoxin, oral antidiabetics, calcium channel blockers, anticoagulants and beta-blockers. When focusing only on major drug interactions, potassium-sparing diuretics and oral anticoagulants were the most frequently involved drugs.CONCLUSION: Elderly patients exposed to polypharmacy should be kept under intensified monitoring as they are at increased risk of clinically significant drug interactions.
AB - OBJECTIVE: To analyse the prevalence of potential drug interactions, and to identify patients particularly prone to drug interaction.DESIGN: Database study (Odense University Pharmacoepidemiologic Database).SETTING: Individuals exposed to polypharmacy in 1999 were examined for potential drug interactions.SUBJECTS: Inhabitants of the County of Funen (n = 471 732).MAIN OUTCOME MEASURES: Prevalence of potential drug interactions.RESULTS: One-third of the population were exposed to polypharmacy and among these 15% were exposed to drugs carrying a risk of harmful interaction. Among the elderly with polypharmacy, 25% aged 60-79 years and 36% over 80 years received drugs carrying the risk of interaction. Among individuals exposed to potential drug interaction, 62% were exposed only to one drug interaction and 38% to two or more different drug interactions. The drugs accounting for the highest number of potential interactions were diuretics, NSAIDs, ACE-inhibitors, digoxin, oral antidiabetics, calcium channel blockers, anticoagulants and beta-blockers. When focusing only on major drug interactions, potassium-sparing diuretics and oral anticoagulants were the most frequently involved drugs.CONCLUSION: Elderly patients exposed to polypharmacy should be kept under intensified monitoring as they are at increased risk of clinically significant drug interactions.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Denmark/epidemiology
KW - Drug Interactions
KW - Family Practice/statistics & numerical data
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Polypharmacy
KW - Risk Factors
U2 - 10.1080/02813430310001806
DO - 10.1080/02813430310001806
M3 - Journal article
C2 - 14531506
VL - 21
SP - 153
EP - 158
JO - Scandinavian Journal of Primary Health Care
JF - Scandinavian Journal of Primary Health Care
SN - 0281-3432
IS - 3
ER -
ID: 324177755