Evolution and regulation of cellular periodic processes: a role for paralogues
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Evolution and regulation of cellular periodic processes: a role for paralogues. / Trachana, Kalliopi; Jensen, Lars Juhl; Bork, Peer.
In: E M B O Reports, Vol. 11, No. 3, 01.03.2010, p. 233-8.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Evolution and regulation of cellular periodic processes: a role for paralogues
AU - Trachana, Kalliopi
AU - Jensen, Lars Juhl
AU - Bork, Peer
PY - 2010/3/1
Y1 - 2010/3/1
N2 - Several cyclic processes take place within a single organism. For example, the cell cycle is coordinated with the 24 h diurnal rhythm in animals and plants, and with the 40 min ultradian rhythm in budding yeast. To examine the evolution of periodic gene expression during these processes, we performed the first systematic comparison in three organisms (Homo sapiens, Arabidopsis thaliana and Saccharomyces cerevisiae) by using public microarray data. We observed that although diurnal-regulated and ultradian-regulated genes are not generally cell-cycle-regulated, they tend to have cell-cycle-regulated paralogues. Thus, diverged temporal expression of paralogues seems to facilitate cellular orchestration under different periodic stimuli. Lineage-specific functional repertoires of periodic-associated paralogues imply that this mode of regulation might have evolved independently in several organisms.
AB - Several cyclic processes take place within a single organism. For example, the cell cycle is coordinated with the 24 h diurnal rhythm in animals and plants, and with the 40 min ultradian rhythm in budding yeast. To examine the evolution of periodic gene expression during these processes, we performed the first systematic comparison in three organisms (Homo sapiens, Arabidopsis thaliana and Saccharomyces cerevisiae) by using public microarray data. We observed that although diurnal-regulated and ultradian-regulated genes are not generally cell-cycle-regulated, they tend to have cell-cycle-regulated paralogues. Thus, diverged temporal expression of paralogues seems to facilitate cellular orchestration under different periodic stimuli. Lineage-specific functional repertoires of periodic-associated paralogues imply that this mode of regulation might have evolved independently in several organisms.
KW - Arabidopsis
KW - Cell Cycle
KW - Computational Biology
KW - Evolution, Molecular
KW - Gene Expression Profiling
KW - Gene Expression Regulation, Fungal
KW - Gene Expression Regulation, Plant
KW - Humans
KW - Models, Biological
KW - Models, Genetic
KW - Multigene Family
KW - Oligonucleotide Array Sequence Analysis
KW - Oxidation-Reduction
KW - Saccharomyces cerevisiae
KW - Time Factors
U2 - 10.1038/embor.2010.9
DO - 10.1038/embor.2010.9
M3 - Journal article
C2 - 20168326
VL - 11
SP - 233
EP - 238
JO - E M B O Reports
JF - E M B O Reports
SN - 1469-221X
IS - 3
ER -
ID: 33750509