Evidence of Extrapancreatic Glucagon Secretion in Man

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Evidence of Extrapancreatic Glucagon Secretion in Man. / Lund, Asger; Bagger, Jonatan I; Wewer Albrechtsen, Nicolai J; Christensen, Mikkel; Grøndahl, Magnus; Hartmann, Bolette; Mathiesen, Elisabeth R; Hansen, Carsten P; Storkholm, Jan H; van Hall, Gerrit; Rehfeld, Jens F; Hornburg, Daniel; Meissner, Felix; Mann, Matthias; Larsen, Steen; Holst, Jens J; Lauritsen, Tina Vilsbøll; Knop, Filip K.

In: Diabetes, Vol. 65, No. 3, 03.2016, p. 585-597.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Lund, A, Bagger, JI, Wewer Albrechtsen, NJ, Christensen, M, Grøndahl, M, Hartmann, B, Mathiesen, ER, Hansen, CP, Storkholm, JH, van Hall, G, Rehfeld, JF, Hornburg, D, Meissner, F, Mann, M, Larsen, S, Holst, JJ, Lauritsen, TV & Knop, FK 2016, 'Evidence of Extrapancreatic Glucagon Secretion in Man', Diabetes, vol. 65, no. 3, pp. 585-597. https://doi.org/10.2337/db15-1541, https://doi.org/10.2337/db16-er06

APA

Lund, A., Bagger, J. I., Wewer Albrechtsen, N. J., Christensen, M., Grøndahl, M., Hartmann, B., Mathiesen, E. R., Hansen, C. P., Storkholm, J. H., van Hall, G., Rehfeld, J. F., Hornburg, D., Meissner, F., Mann, M., Larsen, S., Holst, J. J., Lauritsen, T. V., & Knop, F. K. (2016). Evidence of Extrapancreatic Glucagon Secretion in Man. Diabetes, 65(3), 585-597. https://doi.org/10.2337/db15-1541, https://doi.org/10.2337/db16-er06

Vancouver

Lund A, Bagger JI, Wewer Albrechtsen NJ, Christensen M, Grøndahl M, Hartmann B et al. Evidence of Extrapancreatic Glucagon Secretion in Man. Diabetes. 2016 Mar;65(3):585-597. https://doi.org/10.2337/db15-1541, https://doi.org/10.2337/db16-er06

Author

Lund, Asger ; Bagger, Jonatan I ; Wewer Albrechtsen, Nicolai J ; Christensen, Mikkel ; Grøndahl, Magnus ; Hartmann, Bolette ; Mathiesen, Elisabeth R ; Hansen, Carsten P ; Storkholm, Jan H ; van Hall, Gerrit ; Rehfeld, Jens F ; Hornburg, Daniel ; Meissner, Felix ; Mann, Matthias ; Larsen, Steen ; Holst, Jens J ; Lauritsen, Tina Vilsbøll ; Knop, Filip K. / Evidence of Extrapancreatic Glucagon Secretion in Man. In: Diabetes. 2016 ; Vol. 65, No. 3. pp. 585-597.

Bibtex

@article{80fc42d78b42478487ee68023cbe3868,
title = "Evidence of Extrapancreatic Glucagon Secretion in Man",
abstract = "Glucagon is believed to be a pancreas-specific hormone and hyperglucagonemia has been shown to contribute significantly to the hyperglycemic state of patients with diabetes. This hyperglucagonemia has been thought to arise from alpha cell insensitivity to suppressive effects of glucose and insulin combined with reduced insulin secretion. We hypothesized that postabsorptive hyperglucagonemia represents a gut-dependent phenomenon and subjected 10 totally pancreatectomized patients and 10 healthy controls to a 75g-oral glucose tolerance test and a corresponding isoglycemic intravenous glucose infusion. We applied novel analytical methods of plasma glucagon (sandwich enzyme-linked immunosorbent assay and mass-spectrometry-based proteomics) and show that 29-amino acid glucagon circulates in patients without a pancreas and that glucose stimulation of the gastrointestinal tract elicits significant hyperglucagonemia in these patients. These findings emphasize the existence of extrapancreatic glucagon (perhaps originating from the gut) in man and suggest that it may play a role in diabetes secondary to total pancreatectomy.",
author = "Asger Lund and Bagger, {Jonatan I} and {Wewer Albrechtsen}, {Nicolai J} and Mikkel Christensen and Magnus Gr{\o}ndahl and Bolette Hartmann and Mathiesen, {Elisabeth R} and Hansen, {Carsten P} and Storkholm, {Jan H} and {van Hall}, Gerrit and Rehfeld, {Jens F} and Daniel Hornburg and Felix Meissner and Matthias Mann and Steen Larsen and Holst, {Jens J} and Lauritsen, {Tina Vilsb{\o}ll} and Knop, {Filip K}",
note = "Erratum. Evidence of Extrapancreatic Glucagon Secretion in Man. Diabetes 2016;65:585–597",
year = "2016",
month = mar,
doi = "10.2337/db15-1541",
language = "English",
volume = "65",
pages = "585--597",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association",
number = "3",

}

RIS

TY - JOUR

T1 - Evidence of Extrapancreatic Glucagon Secretion in Man

AU - Lund, Asger

AU - Bagger, Jonatan I

AU - Wewer Albrechtsen, Nicolai J

AU - Christensen, Mikkel

AU - Grøndahl, Magnus

AU - Hartmann, Bolette

AU - Mathiesen, Elisabeth R

AU - Hansen, Carsten P

AU - Storkholm, Jan H

AU - van Hall, Gerrit

AU - Rehfeld, Jens F

AU - Hornburg, Daniel

AU - Meissner, Felix

AU - Mann, Matthias

AU - Larsen, Steen

AU - Holst, Jens J

AU - Lauritsen, Tina Vilsbøll

AU - Knop, Filip K

N1 - Erratum. Evidence of Extrapancreatic Glucagon Secretion in Man. Diabetes 2016;65:585–597

PY - 2016/3

Y1 - 2016/3

N2 - Glucagon is believed to be a pancreas-specific hormone and hyperglucagonemia has been shown to contribute significantly to the hyperglycemic state of patients with diabetes. This hyperglucagonemia has been thought to arise from alpha cell insensitivity to suppressive effects of glucose and insulin combined with reduced insulin secretion. We hypothesized that postabsorptive hyperglucagonemia represents a gut-dependent phenomenon and subjected 10 totally pancreatectomized patients and 10 healthy controls to a 75g-oral glucose tolerance test and a corresponding isoglycemic intravenous glucose infusion. We applied novel analytical methods of plasma glucagon (sandwich enzyme-linked immunosorbent assay and mass-spectrometry-based proteomics) and show that 29-amino acid glucagon circulates in patients without a pancreas and that glucose stimulation of the gastrointestinal tract elicits significant hyperglucagonemia in these patients. These findings emphasize the existence of extrapancreatic glucagon (perhaps originating from the gut) in man and suggest that it may play a role in diabetes secondary to total pancreatectomy.

AB - Glucagon is believed to be a pancreas-specific hormone and hyperglucagonemia has been shown to contribute significantly to the hyperglycemic state of patients with diabetes. This hyperglucagonemia has been thought to arise from alpha cell insensitivity to suppressive effects of glucose and insulin combined with reduced insulin secretion. We hypothesized that postabsorptive hyperglucagonemia represents a gut-dependent phenomenon and subjected 10 totally pancreatectomized patients and 10 healthy controls to a 75g-oral glucose tolerance test and a corresponding isoglycemic intravenous glucose infusion. We applied novel analytical methods of plasma glucagon (sandwich enzyme-linked immunosorbent assay and mass-spectrometry-based proteomics) and show that 29-amino acid glucagon circulates in patients without a pancreas and that glucose stimulation of the gastrointestinal tract elicits significant hyperglucagonemia in these patients. These findings emphasize the existence of extrapancreatic glucagon (perhaps originating from the gut) in man and suggest that it may play a role in diabetes secondary to total pancreatectomy.

UR - http://diabetes.diabetesjournals.org/content/65/6/1752

U2 - 10.2337/db15-1541

DO - 10.2337/db15-1541

M3 - Journal article

C2 - 26672094

VL - 65

SP - 585

EP - 597

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 3

ER -

ID: 152242782